Zobrazeno 1 - 10
of 522
pro vyhledávání: '"Laura E. Niklason"'
Autor:
Mehmet H. Kural, Umidahan Djakbarova, Bilal Cakir, Yoshiaki Tanaka, Emily T. Chan, Valeria I. Arteaga Muniz, Yasaman Madraki, Hong Qian, Jinkyu Park, Lorenzo R. Sewanan, In-Hyun Park, Laura E. Niklason, Comert Kural
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract The transmembrane death receptor Fas transduces apoptotic signals upon binding its ligand, FasL. Although Fas is highly expressed in cancer cells, insufficient cell surface Fas expression desensitizes cancer cells to Fas-induced apoptosis. H
Externí odkaz:
https://doaj.org/article/544a7a26c62646bdaf6e0dc321de4417
Autor:
Katherine L. Leiby, Yifan Yuan, Ronald Ng, Micha Sam Brickman Raredon, Taylor S. Adams, Pavlina Baevova, Allison M. Greaney, Karen K. Hirschi, Stuart G. Campbell, Naftali Kaminski, Erica L. Herzog, Laura E. Niklason
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Engineered whole lungs may one day expand therapeutic options for patients with end-stage lung disease. However, the feasibility of ex vivo lung regeneration remains limited by the inability to recapitulate mature, functional alveolar epithe
Externí odkaz:
https://doaj.org/article/343c803588cf4335a13da17cd8eca48c
Autor:
Oleksandr Sokolov, Vasyl Shaprynskyi, Oleh Skupyy, Oleksandr Stanko, Serhii Yurets, Yuliya Yurkova, Laura E. Niklason
Publikováno v:
The Lancet Regional Health. Europe, Vol 29, Iss , Pp 100650- (2023)
Externí odkaz:
https://doaj.org/article/a4564ff1eae34110998a17f05196458e
Autor:
Micha Sam Brickman Raredon, Junchen Yang, James Garritano, Meng Wang, Dan Kushnir, Jonas Christian Schupp, Taylor S. Adams, Allison M. Greaney, Katherine L. Leiby, Naftali Kaminski, Yuval Kluger, Andre Levchenko, Laura E. Niklason
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the function of tissues and organs. However, the quantification and visualization o
Externí odkaz:
https://doaj.org/article/667f51d390964320809ccc3bfb1c4a68
Autor:
Allison Marie Greaney, Micha Sam Brickman Raredon, Maria P. Kochugaeva, Laura E. Niklason, Andre Levchenko
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106175- (2023)
Summary: Despite much concerted effort to better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection, relatively little is known about the dynamics of early viral entry and infection in the airway. Here we analyzed
Externí odkaz:
https://doaj.org/article/e76d935e39d34605bd7248a4a67b9e0f
Autor:
Allison M. Greaney, Abhay B. Ramachandra, Yifan Yuan, Arina Korneva, Jay D. Humphrey, Laura E. Niklason
Publikováno v:
Biomaterials and Biosystems, Vol 9, Iss , Pp 100074- (2023)
Tracheal replacement using tissue engineering technologies offers great potential to improve previously intractable clinical interventions, and interest in this area has increased in recent years. Many engineered airway constructs currently rely on d
Externí odkaz:
https://doaj.org/article/ff6ce22210604e1da76d7a727f8cbca0
Autor:
Bilal Cakir, Yoshiaki Tanaka, Ferdi Ridvan Kiral, Yangfei Xiang, Onur Dagliyan, Juan Wang, Maria Lee, Allison M. Greaney, Woo Sub Yang, Catherine duBoulay, Mehmet Hamdi Kural, Benjamin Patterson, Mei Zhong, Jonghun Kim, Yalai Bai, Wang Min, Laura E. Niklason, Prabir Patra, In-Hyun Park
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The study of human microglia function in health and disease is limited by the availability of sound models. Here, the authors develop a method to generate functional microglia in human cortical organoids and investigate the role of human microglia du
Externí odkaz:
https://doaj.org/article/f7e442e71a714aed94079c5c43728648
Autor:
Avraham Unterman, Tomokazu S. Sumida, Nima Nouri, Xiting Yan, Amy Y. Zhao, Victor Gasque, Jonas C. Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B. Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G. Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B. F. Vogels, Anne L. Wyllie, Nathan D. Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E. Ruff, Inessa Cohen, Khadir Raddassi, The Yale IMPACT Research Team, Laura E. Niklason, Albert I. Ko, Ruth R. Montgomery, Shelli F. Farhadian, Akiko Iwasaki, Albert C. Shaw, David van Dijk, Hongyu Zhao, Steven H. Kleinstein, David A. Hafler, Naftali Kaminski, Charles S. Dela Cruz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoi
Externí odkaz:
https://doaj.org/article/071dfec07b41418ab54ed9c36dc0d83e
Autor:
Maor Sauler, John E. McDonough, Taylor S. Adams, Neeharika Kothapalli, Thomas Barnthaler, Rhiannon B. Werder, Jonas C. Schupp, Jessica Nouws, Matthew J. Robertson, Cristian Coarfa, Tao Yang, Maurizio Chioccioli, Norihito Omote, Carlos Cosme, Sergio Poli, Ehab A. Ayaub, Sarah G. Chu, Klaus H. Jensen, Jose L. Gomez, Clemente J. Britto, Micha Sam B. Raredon, Laura E. Niklason, Andrew A. Wilson, Pascal N. Timshel, Naftali Kaminski, Ivan O. Rosas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Chronic obstructive pulmonary disease is a leading cause of death worldwide, while our understanding of cell-specific mechanisms underlying its pathobiology remains incomplete. Here the authors perform scRNA-seq of human lung tissue to identify trans
Externí odkaz:
https://doaj.org/article/3579d31a63b3485fb4b3e87914915625
Autor:
Tomasz Jakimowicz, Stanislaw Przywara, Jakub Turek, Alison Pilgrim, Michal Macech, Norbert Zapotoczny, Tomasz Zubilewicz, Jeffrey H. Lawson, Laura E. Niklason
Publikováno v:
EJVES Vascular Forum, Vol 54, Iss , Pp 58-63 (2022)
Objective: Patients with end stage renal failure who require haemodialysis suffer morbidity and mortality due to vascular access. Bioengineered human acellular vessels (HAVs) may provide a haemodialysis access option with fewer complications than oth
Externí odkaz:
https://doaj.org/article/f4303b349841405eac08cc2a9b00cf56