Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laura E Gallagher"'
High risks of losing genetic diversity in an endemic Mauritian gecko: implications for conservation.
Autor:
Steeves Buckland, Nik C Cole, Jim J Groombridge, Clemens Küpper, Terry Burke, Deborah A Dawson, Laura E Gallagher, Stephen Harris
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e93387 (2014)
Genetic structure can be a consequence of recent population fragmentation and isolation, or a remnant of historical localised adaptation. This poses a challenge for conservationists since misinterpreting patterns of genetic structure may lead to inap
Externí odkaz:
https://doaj.org/article/6eb33aa8feb94d238e145e62dc38c4eb
Autor:
Steeves Buckland, Nik C Cole, Jesús Aguirre-Gutiérrez, Laura E Gallagher, Sion M Henshaw, Aurélien Besnard, Rachel M Tucker, Vishnu Bachraz, Kevin Ruhomaun, Stephen Harris
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e88798 (2014)
The invasion of the giant Madagascar day gecko Phelsuma grandis has increased the threats to the four endemic Mauritian day geckos (Phelsuma spp.) that have survived on mainland Mauritius. We had two main aims: (i) to predict the spatial distribution
Externí odkaz:
https://doaj.org/article/d6c4973baa77453698a7e3f9a6bf067e
Publikováno v:
Molecular and Cellular Biology
Autophagy maintains metabolism in response to starvation, but each nutrient is sensed distinctly. Amino acid deficiency suppresses mechanistic target of rapamycin complex 1 (MTORC1), while glucose deficiency promotes AMP-activated protein kinase (AMP
Autor:
Laura E, Gallagher, Ohood A, Radhi, Mahmud O, Abdullah, Anthony G, McCluskey, Marie, Boyd, Edmond Y W, Chan
Publikováno v:
Cell Death & Disease
There has been long-standing interest in targeting pro-survival autophagy as a combinational cancer therapeutic strategy. Clinical trials are in progress testing chloroquine (CQ) or its derivatives in combination with chemo- or radiotherapy for solid
Autor:
Laura E. Gallagher, Edmond Chan
Publikováno v:
Essays in Biochemistry. 55:1-15
Autophagy is a conserved cellular degradative process important for cellular homoeostasis and survival. An early committal step during the initiation of autophagy requires the actions of a protein kinase called ATG1 (autophagy gene 1). In mammalian c
Isolation and characterisation of Mauritius lowland day gecko Phelsuma guimbeaui microsatellite loci
Autor:
Deborah A. Dawson, Gavin J. Horsburgh, Steeves Buckland, Laura E. Gallagher, Andrew P. Krupa, Stephen Harris, Sion M. Henshaw, Jim J. Groombridge, Nik C. Cole
Publikováno v:
Conservation Genetics Resources. 5:1013-1018
We isolated 315 sequences from a Phelsumaguimbeaui microsatellite-enriched genomic library. Primer sets were designed for 44 loci and used to genotype 29 unrelated individuals belonging to a population in the west of Mauritius. All the loci were poly
Publikováno v:
Cells, Vol 5, Iss 2, p 24 (2016)
Cells
Cells
Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a013b6045a8012309299b953daea2c4c
https://strathprints.strath.ac.uk/56971/1/Gallagher_etal_Cells2016_Advances_in_autophagy_regulatory_mechanisms.pdf
https://strathprints.strath.ac.uk/56971/1/Gallagher_etal_Cells2016_Advances_in_autophagy_regulatory_mechanisms.pdf
Publikováno v:
Cancer Research. 78:3808-3808
Tumor Associated Macrophages (TAMs), characteristic of an M2-like immune-suppressive phenotype, can induce proliferation and survival of tumor cells, facilitate angiogenesis, and suppress anti-tumor immune responses via expression of co-inhibitory mo
Autor:
Nik C. Cole, Sion M. Henshaw, Laura E. Gallagher, Steeves Buckland, Stephen Harris, Javier Rodríguez-Pérez, Ben Godsall
Publikováno v:
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Global Ecology and Conservation, Vol 1, Iss C, Pp 71-79 (2014)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Global Ecology and Conservation, Vol 1, Iss C, Pp 71-79 (2014)
Of 30 known subpopulations of Phelsuma guimbeaui, 18 are in patches of exotic forest and are predicted to disappear in the next decade. One possible means of mitigating the reduction in genetic diversity associated with the loss of subpopulations is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13064a5501eb590d2dc9334be93ad70
http://hdl.handle.net/10651/30286
http://hdl.handle.net/10651/30286
Autor:
Janet K. A. Nicholson, Sandra W. Browning, Richard L. Hengel, Edward Lew, Laura E. Gallagher, David Rimland, J. Steven McDougal
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes. 27:105-115