Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Laura E, Randle"'
Autor:
Ross A Kelly, Joseph Leedale, Andy Harrell, Daniel A Beard, Laura E Randle, Amy E Chadwick, Steven D Webb
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207803 (2018)
Cancer cells depend on glucose metabolism via glycolysis as a primary energy source, despite the presence of oxygen and fully functioning mitochondria, in order to promote growth, proliferation and longevity. Glycolysis relies upon NAD+ to accept ele
Externí odkaz:
https://doaj.org/article/6175f3db99624567aabd4c19c5b8a565
Autor:
Said Alizadeh-Shekalgourabi, Sam P. de Visser, James F. Dunn, Alistair J. Fielding, Michael G. B. Drew, Fyaz M.D. Ismail, Fabián G. Cantú Reinhard, Alessio del Casino, Nicola M. Dempster, Philip G. Evans, Verity Male, Dascombe Mj, Valentina Lukinović, Roger H. Bisby, Lutfun Nahar, Satyajit D. Sarker, Laura E. Randle
Publikováno v:
Fielding, A, Lukinović, V, Evans, P G, Alizadeh-Shekalgourabi, S, Bisby, R H, Drew, M G B, ADel Casino, A, Dunn, J F, Randle, L E, Dempster, N M, Nahar, L, Sarker, S D, Cantu Reinhard, F, De Visser, S, Dascombe, M & Ismail, F M D 2017, ' Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines ', Chemistry: A European Journal, vol. 23, no. 28, pp. 6811-6828 . https://doi.org/10.1002/chem.201605099
Antimalarials can interact with heme covalently, by π⋅⋅⋅π interactions or by hydrogen bonding. Consequently, the prototropy of 4-aminoquinolines and quinoline methanols was investigated by using quantum mechanics. Calculations showed mefloqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d03c9f8537ab54ae4ac5893b4cee3db
https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc7h472&sid=DataCite
https://www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccdc.csd.cc7h472&sid=DataCite
Autor:
John Farrell, Sophie L. Regan, Dominic P. Williams, Neil R. Kitteringham, Alvin J. L. Chia, Laura E. Randle, Abhishek Srivastava, Christopher E. Goldring, Andrew V. Stachulski, Dean J. Naisbitt, Daniel J. Antoine, Thomas A. Baillie, Martin S. Lennard, J. Luis Castrejon, Hayley Callan, B. Kevin Park, Deepak Dalvie, R. Scott Obach
Publikováno v:
Medicinal Research Reviews. 33:985-1080
The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is preclinical toxicity, frequently attributed to the generation of protein-reactive drug met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1217e6dd82cee0f0556c3901275f778b
https://doi.org/10.1002/med.21273
https://doi.org/10.1002/med.21273
Autor:
Neil R. Kitteringham, Samantha J. Williams, Laura E. Randle, B. Kevin Park, Christopher M. Sanderson, Azman Abdullah, Christopher E. Goldring, Rowena L. Sison, Joanne Walsh, Rosalind E. Jenkins, John D. Hayes, Larry G. Higgins, Helen Powell, Masayuki Yamamoto
Publikováno v:
Journal of Proteomics
The transcription factor Nrf2 regulates expression of multiple cellular defence proteins through the antioxidant response element (ARE). Nrf2-deficient mice (Nrf2−/−) are highly susceptible to xenobiotic-mediated toxicity, but the precise molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1800480ceb557ba146625a209e185e
Autor:
Dominic P. Williams, Neil R. Kitteringham, Laura E. Randle, Jean G. Sathish, B.K. Park, I Macdonald
Publikováno v:
British Journal of Pharmacology. 153:820-830
Background and purpose: Paracetamol, a major cause of acute liver failure (ALF) represents a significant clinical problem. Adrenoceptor stimulation or antagonism can modulate chemical-induced hepatotoxicity. We investigated the role of endogenous cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5acb7a0d11b92f19f28f6b1a6f026c66
https://doi.org/10.1038/sj.bjp.0707620
https://doi.org/10.1038/sj.bjp.0707620
Autor:
Andrew V, Stachulski, Thomas A, Baillie, B Kevin, Park, R Scott, Obach, Deepak K, Dalvie, Dominic P, Williams, Abhishek, Srivastava, Sophie L, Regan, Daniel J, Antoine, Christopher E P, Goldring, Alvin J L, Chia, Neil R, Kitteringham, Laura E, Randle, Hayley, Callan, J Luis, Castrejon, John, Farrell, Dean J, Naisbitt, Martin S, Lennard
Publikováno v:
Medicinal research reviews. 33(5)
The decline in approval of new drugs during the past decade has led to a close analysis of the drug discovery process. One of the main reasons for attrition is preclinical toxicity, frequently attributed to the generation of protein-reactive drug met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d88108b8bcf52152a08943373b43a994
https://pubmed.ncbi.nlm.nih.gov/23090860
https://pubmed.ncbi.nlm.nih.gov/23090860
Autor:
Alvin J. L. Chia, John D. Hayes, B. Kevin Park, Christopher E. Goldring, Neil R. Kitteringham, Rosalind E. Jenkins, Laura E. Randle, Ian M. Copple
Publikováno v:
Hepatology (Baltimore, Md.). 48(4)
The transcription factor Nrf2 regulates the expression of numerous cytoprotective genes in mammalian cells. We have demonstrated previously that acetaminophen activates Nrf2 in mouse liver following administration of non-hepatotoxic and hepatotoxic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1ed30d3c459e9591744cb5703b4f37
https://pubmed.ncbi.nlm.nih.gov/18785192
https://pubmed.ncbi.nlm.nih.gov/18785192
Autor:
Dominic P. Williams, Christopher E. Goldring, Peter Metcalfe, Craig Benson, B. Kevin Park, Neil R. Kitteringham, Laura E. Randle
Publikováno v:
Toxicology. 243(3)
The Keap1-Nrf2-ARE signalling pathway has emerged as an important regulator of the mammalian defence system to enable detoxification and clearance of foreign chemicals. Recent studies by our group using paracetamol (APAP), diethylmaleate and buthioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c7e84183c08d2a55e40b42d0716498
https://pubmed.ncbi.nlm.nih.gov/18078705
https://pubmed.ncbi.nlm.nih.gov/18078705
Autor:
Julian Blagg, Dominic P. Williams, Daniel J. Antoine, Laura E. Randle, Martin Howard, Russell Jones, B. Kevin Park, Iain Gardner, Philip J. Butler, Anthony Payne
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 322(3)
Furosemide, a loop diuretic, causes hepatic necrosis in mice. Previous evidence suggested hepatotoxicity arises from metabolic bioactivation to a chemically reactive metabolite that binds to hepatic proteins. To define the nature of the toxic metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b022cc78d2c8197af68055c483f191e9
https://pubmed.ncbi.nlm.nih.gov/17556636
https://pubmed.ncbi.nlm.nih.gov/17556636
Autor:
Cerys A. Lovatt, Dominic P. Williams, Andrew Owen, Wolfgang Hillen, Philip J. Butler, Xiao-Ping Liu, Christian Berens, Azman Abdullah, Peter Metcalfe, Rosalind E. Jenkins, B. Kevin Park, Alec W.M. Simpson, Neil R. Kitteringham, Laura E. Randle, Lesley I. McLellan, Christopher E. Goldring, Brian Foster
Publikováno v:
American journal of physiology. Cell physiology. 290(1)
Precise control of the level of protein expression in cells can yield quantitative and temporal information on the role of a given gene in normal cellular physiology and on exposure to chemicals and drugs. This is particularly relevant to liver cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db496917bfaf8c3918433d7061f1584
https://pubmed.ncbi.nlm.nih.gov/16338979
https://pubmed.ncbi.nlm.nih.gov/16338979