Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Laura E, Nagy"'
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 219-237 (2024)
Abstract Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered attention for its role in various pathological conditions. While initially recognized for its involvement in cell death, recent research has revealed that k
Externí odkaz:
https://doaj.org/article/584acbe71ae74f5794bca46f8ef63a7f
Autor:
Venkateshwari Varadharajan, Iyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Anthony J Horak, Megan R McMullen, Emily Huang, Annette Bellar, Shuhui W Lorkowski, Kailash Gulshan, Robert N Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, David Streem, Ofer Reizes, Daniela S Allende, Jonathan D Smith, Judith Simcox, Laura E Nagy, J Mark Brown
Publikováno v:
eLife, Vol 12 (2024)
Recent genome-wide association studies (GWAS) have identified a link between single-nucleotide polymorphisms (SNPs) near the MBOAT7 gene and advanced liver diseases. Specifically, the common MBOAT7 variant (rs641738) associated with reduced MBOAT7 ex
Externí odkaz:
https://doaj.org/article/3c5d86faa2f749f9b1ff225029440203
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1750-1750 (2024)
Externí odkaz:
https://doaj.org/article/05021117b76a4d388998c05c3029efbe
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThe RIP1-RIP3-MLKL-mediated cell death pathway is associated with progression of non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Previous work identified a critical role for MLKL, the key effector regulating necroptosis, but
Externí odkaz:
https://doaj.org/article/b59b614ce2774f44987134d4f15e2a72
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/1cd073151bf74c9d9ace6d62e5bfde80
Autor:
Adam Kim, Martí Ortega-Ribera, Megan R. McMullen, Annette Bellar, Moyinoluwa Taiwo, Vai Pathak, David Streem, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, Vidula Vachharajani, Laura E. Nagy
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107133- (2023)
Summary: Alcohol abuse causes increased susceptibility to respiratory syndromes like bacterial pneumonia and viral infections like SARS-CoV-2. Heavy drinkers (HD) are at higher risk of severe COVID-19 if they are also overweight, yet the molecular me
Externí odkaz:
https://doaj.org/article/d98479cccd364976b87e0478ee4d52c3
Autor:
Vaibhav Singh, Emily Huang, Vai Pathak, Belinda B. Willard, Daniela S. Allende, Laura E. Nagy
Publikováno v:
Hepatology Communications, Vol 6, Iss 8, Pp 2022-2041 (2022)
Abstract Receptor‐interaction protein kinase 3 (RIP3), a critical determinant of the necroptotic pathway of programmed cell death, contributes to injury in murine models of alcohol‐associated liver disease (ALD); however, the underlying mechanism
Externí odkaz:
https://doaj.org/article/974b328ba1bd4c6faf9e36f297f4cc24
Autor:
Annette Bellar, Nicole Welch, Jaividhya Dasarathy, Amy Attaway, Ryan Musich, Avinash Kumar, Jinendiran Sekar, Saurabh Mishra, Yana Sandlers, David Streem, Laura E Nagy, Srinivasan Dasarathy
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Background Patients with acute alcohol‐associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformat
Externí odkaz:
https://doaj.org/article/881a67875696428382c69cb550c103a6
Autor:
Quanri Zhang, Weiwei Liu, Han Wang, Hao Zhou, Katarzyna Bulek, Xing Chen, Cun-Jin Zhang, Junjie Zhao, Renliang Zhang, Caini Liu, Zizhen Kang, Robert A. Bermel, George Dubyak, Derek W. Abbott, Tsan Sam Xiao, Laura E. Nagy, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mincle is a pattern recognition receptor that senses danger signals in innate immune cells. Here authors show in an experimental autoimmune encephalomyelitis mouse model that tissue damage triggers Mincle signaling on inflammatory helper T cells, lea
Externí odkaz:
https://doaj.org/article/9dba327f0fa94c719a5ed5ddd82cfffe
Autor:
C. Alicia Traughber, Gauravi M. Deshpande, Kalash Neupane, Nilam Bhandari, Mariam R. Khan, Megan R. McMullen, Shadi Swaidani, Emmanuel Opoku, Santoshi Muppala, Jonathan D. Smith, Laura E. Nagy, Kailash Gulshan
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106076- (2023)
Summary: The activities of the NLRP3 and AIM2 inflammasomes and Gasdermin D (GsdmD) are implicated in lung cancer pathophysiology but it’s not clear if their contributions promote or retard lung cancer progression. Using a metastatic Lewis lung car
Externí odkaz:
https://doaj.org/article/01281b11f26d44f2bd22e002e5c57436