Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura E, Blue"'
Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
Autor:
Liang Zhang, Daniel J. Griffin, Matthew G. Beaver, Laura E. Blue, Christopher J. Borths, Derek B. Brown, Seb Caille, Ying Chen, Alan H. Cherney, Brian M. Cochran, John T. Colyer, Michael T. Corbett, Tiffany L. Correll, Richard D. Crockett, Xi-Jie Dai, Peter K. Dornan, Robert P. Farrell, Simon J. Hedley, Hsiao-Wu Hsieh, Liang Huang, Seth Huggins, Min Liu, Michael A. Lovette, Kyle Quasdorf, William Powazinik, Jonathan Reifman, Jo Anna Robinson, Rahul P. Sangodkar, Sonika Sharma, Srividya Sharvan Kumar, Austin G. Smith, Gabrielle St-Pierre, Jason S. Tedrow, Oliver R. Thiel, Jonathan V. Truong, Shawn D. Walker, Carolyn S. Wei, Ashraf Wilsily, Yong Xie, Ning Yang, Andrew T. Parsons
Publikováno v:
Organic Process Research & Development. 26:3115-3125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::972bf6936d6ce0633f15e7dda136b897
https://doi.org/10.1021/acs.oprd.2c00249
https://doi.org/10.1021/acs.oprd.2c00249
Autor:
Laura E. Blue
Publikováno v:
LCGC North America. :360-362
Most molecules with therapeutic value have at least one chiral center, requiring resolution of both achiral and chiral impurities. Separate achiral and chiral methods are the most used methodologies, but two-dimensional (2D) methods and columns in se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16b397126e625bb736e6f262a9e37b7
https://doi.org/10.56530/lcgc.na.yy3879t6
https://doi.org/10.56530/lcgc.na.yy3879t6
Autor:
Laura E, Blue, Xiaoyan, Guan, Marisa K, Joubert, Scott T, Kuhns, Stephanie, Moore, David J, Semin, Mats, Wikström, Jette, Wypych, Chetan T, Goudar
Publikováno v:
Current Opinion in Biotechnology. 78:102800
The biopharmaceutical landscape continues to evolve rapidly, and associated modality complexity and the need to improve molecular understanding require concomitant advances in analytical approaches used to characterize and release the product. The Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e64543094719431cf1a214789f83f4
https://doi.org/10.1016/j.copbio.2022.102800
https://doi.org/10.1016/j.copbio.2022.102800
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32(8)
The aspiration of the multi-attribute method (MAM) is to utilize a single mass spectrometry-based method that can measure multiple attributes simultaneously, thus enabling data-driven decisions more quickly and efficiently. However, challenges associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1940be56b03aac808afba12fd4c94d9b
https://pubmed.ncbi.nlm.nih.gov/33730487
https://pubmed.ncbi.nlm.nih.gov/33730487
Autor:
Nilesh Joshi, Bob Farrell, Jessica Tan, Justine Paulose, Athimoolam Pillai, Jason S. Tedrow, Balaji Dhamarlapati, Laura E. Blue
Publikováno v:
Journal of Chromatography A. 1538:108-111
A normal phase liquid chromatography method was developed for the separation and detection of eight stereoisomers of the key intermediate, CORE + OMe, having three chiral centers. The stereochemistry of this intermediate dictates the stereochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a314b8824f121c7b6976afafdaefce
https://doi.org/10.1016/j.chroma.2018.01.035
https://doi.org/10.1016/j.chroma.2018.01.035
Autor:
Laura E. Blue, James W. Jorgenson
Publikováno v:
Journal of Chromatography A. 1380:71-80
The predicted advantages of superficially porous particles over totally porous particles are decreased eddy dispersion, longitudinal diffusion, and resistance to mass transfer contributions to the theoretical plate height. While sub-2 micron superfic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927a2450aca41ac429ac8a077a7d682b
https://doi.org/10.1016/j.chroma.2014.12.055
https://doi.org/10.1016/j.chroma.2014.12.055
Autor:
Justin M. Godinho, Edward G. Franklin, James P. Grinias, Stephanie M. Moore, Daniel B. Lunn, Laura E. Blue, Kaitlin M. Grinias
Publikováno v:
Journal of chromatography. A. 1523
In the twenty years since its initial demonstration, capillary ultrahigh pressure liquid chromatography (UHPLC) has proven to be one of most powerful separation techniques for the analysis of complex mixtures. This review focuses on the most recent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f79a8556a4d7b1e0586b9f26c1e266
https://pubmed.ncbi.nlm.nih.gov/28599863
https://pubmed.ncbi.nlm.nih.gov/28599863
Publikováno v:
Analytical Chemistry. 84:4496-4503
We derive a quantitative relationship between the bed morphology and the chromatographic separation efficiency of capillary columns packed with sub-2 μm particles, covering capillary inner diameters from 10 to 75 μm. Our study focuses on wall effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6948e87f9bc5d2c17d983697ffdcf7
https://doi.org/10.1021/ac300326k
https://doi.org/10.1021/ac300326k
Autor:
Laura E, Blue, James W, Jorgenson
Publikováno v:
Journal of chromatography. A. 1380
The predicted advantages of superficially porous particles over totally porous particles are decreased eddy dispersion, longitudinal diffusion, and resistance to mass transfer contributions to the theoretical plate height. While sub-2 micron superfic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ff72879e574463bc103609c22acb5ed
https://pubmed.ncbi.nlm.nih.gov/25578043
https://pubmed.ncbi.nlm.nih.gov/25578043
Autor:
James W. Jorgenson, Laura E. Blue
Publikováno v:
Journal of chromatography. A. 1218(44)
Superficially porous particles are characterized by a non-porous particle core surrounded by a thin porous layer. Superficially porous particles have been shown to have chromatographic advantages over traditional totally porous particles by reducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ebb2efbad3a078f8718286eddd5f8
https://pubmed.ncbi.nlm.nih.gov/21939979
https://pubmed.ncbi.nlm.nih.gov/21939979