Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Laura Denby"'
Autor:
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expre
Externí odkaz:
https://doaj.org/article/3754b0ae722445b28dc0fc7b7de55dfa
Autor:
Shanmugakumar Chinnappa, Azhar Maqbool, Hema Viswambharan, Andrew Mooney, Laura Denby, Mark Drinkhill
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 373 (2023)
Heart failure and chronic kidney disease (CKD) share several mediators of cardiac pathological remodelling. Akin to heart failure, this remodelling sets in motion a vicious cycle of progressive pathological hypertrophy and myocardial dysfunction in C
Externí odkaz:
https://doaj.org/article/059f45544db24b7c8fb2d91d026c687e
Autor:
Eoin D. O’Sullivan, Katie J. Mylonas, Rachel Bell, Cyril Carvalho, David P. Baird, Carolynn Cairns, Kevin M. Gallagher, Ross Campbell, Marie Docherty, Alexander Laird, Neil C. Henderson, Tamir Chandra, Kristina Kirschner, Bryan Conway, Gry H. Dihazi, Michael Zeisberg, Jeremy Hughes, Laura Denby, Hassan Dihazi, David A. Ferenbach
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with aging and after injury and are implicated in organ fibrosis, but the mechanisms by which sene
Externí odkaz:
https://doaj.org/article/4b3de86c4fb74e508d5ddb5a3c0e0003
Autor:
Fernando de la Cuesta, Ilaria Passalacqua, Julie Rodor, Raghu Bhushan, Laura Denby, Andrew H. Baker
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background Excessive TGF-β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and significance have not yet be
Externí odkaz:
https://doaj.org/article/9aaed96be6ec4571a3fcbc7f6ec6e3b7
Autor:
Olivia Matthews, Emma E. Morrison, John D. Tranter, Philip Starkey Lewis, Iqbal S. Toor, Abhishek Srivastava, Rebecca Sargeant, Helen Rollison, Kylie P. Matchett, Timothy J. Kendall, Gillian A. Gray, Chris Goldring, Kevin Park, Laura Denby, Neeraj Dhaun, Matthew A. Bailey, Neil C. Henderson, Dominic Williams, James W. Dear
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103092- (2020)
Background: Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate microRNA transfer from liver to kidney. Methods: Dicerflox/flox mic
Externí odkaz:
https://doaj.org/article/6471fb5992d44958b700cf85b5053236
Autor:
Katie L. Connor, Oliver Teenan, Carolynn Cairns, Victoria Banwell, Rachel A.B. Thomas, Julie Rodor, Sarah Finnie, Riinu Pius, Gillian M. Tannahill, Vishal Sahni, Caroline O.S. Savage, Jeremy Hughes, Ewen M. Harrison, Robert B. Henderson, Lorna P. Marson, Bryan R. Conway, Stephen J. Wigmore, Laura Denby
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Small noncoding RNAs, miRNAs (miRNAs), are emerging as important modulators in the pathogenesis of kidney disease, with potential as biomarkers of kidney disease onset, progression, or therapeutic efficacy. Bulk tissue small RNA-sequencing (sRNA-Seq)
Externí odkaz:
https://doaj.org/article/0e57397672654b13af1fc22e1d4a45d8
Autor:
James O’Sullivan, Sarah Louise Finnie, Oliver Teenan, Carolynn Cairns, Andrew Boyd, Matthew A. Bailey, Adrian Thomson, Jeremy Hughes, Cécile Bénézech, Bryan Ronald Conway, Laura Denby
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Chronic kidney disease (CKD) is prevalent worldwide and is associated with significant co-morbidities including cardiovascular disease (CVD). Traditionally, the subtotal nephrectomy (remnant kidney) experimental model has been performed in rats to mo
Externí odkaz:
https://doaj.org/article/4030948669044e64aad1e6228a22ae92
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 12, Pp 1419-1433 (2016)
The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome en
Externí odkaz:
https://doaj.org/article/5e2b82ec40dd485d849c393926b5e345
Autor:
Eoin D. O’Sullivan, Katie J. Mylonas, Cuiyan Xin, David P. Baird, Cyril Carvalho, Marie-Helena Docherty, Ross Campbell, Kylie P. Matchett, Scott H. Waddell, Alexander D. Walker, Kevin M. Gallagher, Siyang Jia, Steve Leung, Alexander Laird, Julia Wilflingseder, Michaela Willi, Maximilian Reck, Sarah Finnie, Angela Pisco, Sabrina Gordon-Keylock, Alexander Medvinsky, Luke Boulter, Neil C. Henderson, Kristina Kirschner, Tamir Chandra, Bryan R. Conway, Jeremy Hughes, Laura Denby, Joseph V. Bonventre, David A. Ferenbach
Publikováno v:
Science Translational Medicine. 15
Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1 + ) cells are a major source of activated fibroblasts in multiple organs, but the l
Autor:
Laura Denby, Rachel M.B. Bell
Publikováno v:
Bell, R M B & Denby, L 2021, ' Myeloid heterogeneity in kidney disease as revealed through single cell RNA sequencing ', Kidney360, pp. 10.34067/KID.0003682021 . https://doi.org/10.34067/KID.0003682021
Kidney360
Kidney360
Kidney disease represents a global health burden of increasing prevalence and is an independent risk factor for cardiovascular disease. Myeloid cells are a major cellular compartment of the immune system; they are found in the healthy kidney and in i