Výsledky vyhledávání - "Laura Demopoulos"

Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease

Autor: Melissa Bonner, Naoya Uchida, James Rottman, Julie Kanter, Matthew M. Hsieh, Manfred G. Schmidt, Alexis A. Thompson, Francis J. Pierciey, Mark C. Walters, Mohammed Asmal, John F. Tisdale, Laura Demopoulos

Publikováno v: Blood Adv

Key Points Ability to accurately attribute adverse events post–gene therapy is required to describe the benefit-risk of these novel treatments. A SCD patient developed myelodysplastic syndrome post-LentiGlobin treatment; we show how insertional onc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e8d86aac2d3adf7a1ae1174faf644e
https://doi.org/10.1182/bloodadvances.2019001330

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Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction

Autor: Thomas F Haws, Robert J. Gropler, John J. Lepore, Michael J. Fossler, Laura Demopoulos, Victor G. Davila-Roman, Eric Olson, Zixing Fang, April M. Barbour, Stuart D. Russell

Publikováno v: JACC: Heart Failure. 4:559-566

Objectives This study sought to determine if glucagon-like peptide (GLP)-1 ameliorates myocardial metabolic abnormalities in chronic heart failure. Background Albiglutide (GSK716155) is a GLP-1 agonist indicated for type 2 diabetes. Methods We perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c156398f9f77087d7d4a8461470f0f
https://doi.org/10.1016/j.jchf.2016.01.008

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Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

Autor: Thomas F Haws, Kelly M. Mahar, Laura Demopoulos, Erding Hu, Zixing Fang, Pu Qin, William R. Hiatt, Timothy A. Bauer, Eric Olson, John J. Lepore

Publikováno v: Vascular Medicine. 19:473-482

Hypoxia inducible factor (HIF) stabilization by HIF-prolyl hydroxylase (PHD) inhibitors may improve ischemic conditions such as peripheral artery disease (PAD). This multicenter, randomized, placebo-controlled study evaluated the safety and efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d22d721b9f7b58d1eeaa2e32ad7802
https://doi.org/10.1177/1358863x14557151

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Angiographic variables predict increased risk for adverse ischemic events after coronary stenting with glycoprotein IIb/IIIa inhibition: results from the TARGET trial

Autor: Mitchell J, Ross, Howard C, Herrmann, David J, Moliterno, James C, Blankenship, Laura, Demopoulos, Peter M, DiBattiste, Stephen G, Ellis, Ziyad, Ghazzal, Jack L, Martin, Jennifer, White, Eric J, Topol

Publikováno v: Journal of the American College of Cardiology. 42(6)

We sought to assess whether pre-procedural angiographic characteristics are associated with adverse clinical outcomes after coronary stenting with glycoprotein IIb/IIIa inhibition.Ischemic complications after balloon angioplasty are associated with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::457c18d2eccbe9cf7f7a9b06b892f487
https://pubmed.ncbi.nlm.nih.gov/13678917

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Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients

Autor: Lisa Gazdick, Charlena Fletcher, Paul R. Conlin, Laura Demopoulos, Stephen L. Swartz, Eliav Barr, Thomas J. Moore, Paul DeLucca

Publikováno v: Hypertension (Dallas, Tex. : 1979). 36(3)

Abstract —NSAIDs are known to attenuate the effects of some antihypertensive medications. It is not known whether the new class of angiotensin II receptor antagonists is similarly affected. We conducted a multicenter study assessing the effect of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ace2e1c17b9582f3e7b8c36ea2468a
https://pubmed.ncbi.nlm.nih.gov/10988282

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Results of the Treat Angina With Aggrastat and Determine the Cost of Therapy With an Invasive or Conservative Strategy (TACTICS-TIMI 18) Trial: A Comparison of Invasive Versus Conservative Strategy in Patients With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction

Autor: William S. Weintraub, Eugene Braunwald, Paul DeLucca, Debbie Robertson, Carolyn H. McCabe, Laura Demopoulos, Christopher P. Cannon

Publikováno v: Circulation. 102:2672-2672

Background : In the treatment of patients with unstable angina and non-ST segment elevation myocardial infarction (UA/NSTEMI), debate exists as to whether an early invasive vs. a conservative strategy is optimal therapy. Methods: In the international

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a041d3f0954ad081cd407ebbb1d2c51
https://doi.org/10.1161/01.cir.102.21.2672-a

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