Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells

Autor: Inge Baas, Laura Delvasto-Nuñez, Peter Ligthart, Conny Brouwer, Claudia Folman, Edimara S. Reis, Daniel Ricklin, John D. Lambris, Diana Wouters, Masja de Haas, Ilse Jongerius, Sacha S. Zeerleder

Publikováno v: Haematologica, Vol 105, Iss 2 (2020)

Externí odkaz: https://doaj.org/article/080d337720a34853a8f979a034075c99

Iron-Driven Alterations on Red Blood Cell-Derived Microvesicles Amplify Coagulation during Hemolysis via the Intrinsic Tenase Complex

Autor: Ilse Jongerius, Sacha Zeerleder, Laura Delvasto-Nuñez, Kamran Bakhtiari, Joost C. M. Meijers, Dorina Roem, Gerard van Mierlo

Publikováno v: Delvasto, Laura; Roem, Dorina; Bakhtiari, Kamran; van Mierlo, Gerard J; Meijers, Joost; Jongerius, Ilse; Zeerleder, Sacha S (2022). Iron-driven alterations on red blood cell-derived microvesicles amplify coagulation during hemolysis via the intrinsic tenase complex. Thrombosis and haemostasis, 122(1), pp. 80-91. Thieme 10.1055/a-1497-9573
Thrombosis and haemostasis. Schattauer GmbH

Hemolytic disorders characterized by complement-mediated intravascular hemolysis, such as autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria, are often complicated by life-threatening thromboembolic complications. Severe hemolytic ep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203c54f9658be5113d3ae4d20d6bf3be
https://doi.org/10.1055/a-1497-9573

It takes two to thrombosis: Hemolysis and complement

Autor: Ilse Jongerius, Laura Delvasto-Nuñez, Sacha Zeerleder

Publikováno v: Blood reviews. 50

Thromboembolic events represent the most common complication of hemolytic anemias characterized by complement-mediated hemolysis such as paroxysmal nocturnal hemoglobinuria and autoimmune hemolytic anemia. Similarly, atypical hemolytic uremic syndrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae31129c62f622d188e1052111cc6f55
https://pubmed.ncbi.nlm.nih.gov/33985796

α1-Antichymotrypsin Present in Therapeutic C1-Inhibitor Products Competes with Selectin-Sialyl Lewis X Interaction

Autor: Manfred Wuhrer, Diana Wouters, Gerard van Mierlo, Dorina Roem, Ruchira Engel, Laura Delvasto-Nuñez, Agnes L. Hipgrave Ederveen, Stephanie Holst, Sacha Zeerleder, Jaap D. van Buul

Publikováno v: Thrombosis and Haemostasis
Thrombosis and haemostasis, 118(12), 2134-2144. Schattauer GmbH

Background C1-inhibitor (C1-inh) therapeutics can reduce neutrophil activity in various inflammatory conditions. This ‘novel’ anti-inflammatory effect of C1-inh is attributed to the tetrasaccharide sialyl LewisX (SLeX) present on its N-glycans. V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2305b75d45766148f52173d990e8a136
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057728826&origin=inward