Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

Autor: Samantha E. Hoffman, Todd W. Dowrey, Carlos Villacorta Martin, Kevin Bi, Breanna Titchen, Shreya Johri, Laura DelloStritto, Miraj Patel, Colin Mackichan, Stephanie Inga, Judy Chen, Grace Grimaldi, Sara Napolitano, Isaac Wakiro, Jingyi Wu, Jason Yeung, Asaf Rotem, Erin Shannon, Thomas Clancy, Jiping Wang, Sarah Denning, Lauren Brais, Ying Huang, Katrina Z. Kao, Scott Rodig, Jason L. Hornick, Sebastien Vigneau, Jihye Park, Matthew H. Kulke, Jennifer Chan, Eliezer M. Van Allen, George J. Murphy

Neuroendocrine tumors (NETs) are rare cancers that may arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP) NET growth remain incompletely elucidated; however, the heterogeneous clinical be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73fedd639cee1edb657fcca70029a49d
https://doi.org/10.1101/2022.11.08.515538

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Autor: Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, Ethan Cerami, Robert J. Coffey, Emek Demir, Li Ding, Edward D. Esplin, James M. Ford, Jeremy Goecks, Sharmistha Ghosh, Joe W. Gray, Justin Guinney, Sean E. Hanlon, Shannon K. Hughes, E. Shelley Hwang, Christine A. Iacobuzio-Donahue, Judit Jané-Valbuena, Bruce E. Johnson, Ken S. Lau, Tracy Lively, Sarah A. Mazzilli, Dana Pe’er, Sandro Santagata, Alex K. Shalek, Denis Schapiro, Michael P. Snyder, Peter K. Sorger, Avrum E. Spira, Sudhir Srivastava, Kai Tan, Robert B. West, Elizabeth H. Williams, Denise Aberle, Samuel I. Achilefu, Foluso O. Ademuyiwa, Andrew C. Adey, Rebecca L. Aft, Rachana Agarwal, Ruben A. Aguilar, Fatemeh Alikarami, Viola Allaj, Christopher Amos, Robert A. Anders, Michael R. Angelo, Kristen Anton, Jon C. Aster, Ozgun Babur, Amir Bahmani, Akshay Balsubramani, David Barrett, Jennifer Beane, Diane E. Bender, Kathrin Bernt, Lynne Berry, Courtney B. Betts, Julie Bletz, Katie Blise, Adrienne Boire, Genevieve Boland, Alexander Borowsky, Kristopher Bosse, Matthew Bott, Ed Boyden, James Brooks, Raphael Bueno, Erik A. Burlingame, Qiuyin Cai, Joshua Campbell, Wagma Caravan, Hassan Chaib, Joseph M. Chan, Young Hwan Chang, Deyali Chatterjee, Ojasvi Chaudhary, Alyce A. Chen, Bob Chen, Changya Chen, Chia-hui Chen, Feng Chen, Yu-An Chen, Milan G. Chheda, Koei Chin, Roxanne Chiu, Shih-Kai Chu, Rodrigo Chuaqui, Jaeyoung Chun, Luis Cisneros, Graham A. Colditz, Kristina Cole, Natalie Collins, Kevin Contrepois, Lisa M. Coussens, Allison L. Creason, Daniel Crichton, Christina Curtis, Tanja Davidsen, Sherri R. Davies, Ino de Bruijn, Laura Dellostritto, Angelo De Marzo, David G. DeNardo, Dinh Diep, Sharon Diskin, Xengie Doan, Julia Drewes, Stephen Dubinett, Michael Dyer, Jacklynn Egger, Jennifer Eng, Barbara Engelhardt, Graham Erwin, Laura Esserman, Alex Felmeister, Heidi S. Feiler, Ryan C. Fields, Stephen Fisher, Keith Flaherty, Jennifer Flournoy, Angelo Fortunato, Allison Frangieh, Jennifer L. Frye, Robert S. Fulton, Danielle Galipeau, Siting Gan, Jianjiong Gao, Long Gao, Peng Gao, Vianne R. Gao, Tim Geiger, Ajit George, Gad Getz, Marios Giannakis, David L. Gibbs, William E. Gillanders, Simon P. Goedegebuure, Alanna Gould, Kate Gowers, William Greenleaf, Jeremy Gresham, Jennifer L. Guerriero, Tuhin K. Guha, Alexander R. Guimaraes, David Gutman, Nir Hacohen, Sean Hanlon, Casey R. Hansen, Olivier Harismendy, Kathleen A. Harris, Aaron Hata, Akimasa Hayashi, Cody Heiser, Karla Helvie, John M. Herndon, Gilliam Hirst, Frank Hodi, Travis Hollmann, Aaron Horning, James J. Hsieh, Shannon Hughes, Won Jae Huh, Stephen Hunger, Shelley E. Hwang, Heba Ijaz, Benjamin Izar, Connor A. Jacobson, Samuel Janes, Reyka G. Jayasinghe, Lihua Jiang, Brett E. Johnson, Bruce Johnson, Tao Ju, Humam Kadara, Klaus Kaestner, Jacob Kagan, Lukas Kalinke, Robert Keith, Aziz Khan, Warren Kibbe, Albert H. Kim, Erika Kim, Junhyong Kim, Annette Kolodzie, Mateusz Kopytra, Eran Kotler, Robert Krueger, Kostyantyn Krysan, Anshul Kundaje, Uri Ladabaum, Blue B. Lake, Huy Lam, Rozelle Laquindanum, Ashley M. Laughney, Hayan Lee, Marc Lenburg, Carina Leonard, Ignaty Leshchiner, Rochelle Levy, Jerry Li, Christine G. Lian, Kian-Huat Lim, Jia-Ren Lin, Yiyun Lin, Qi Liu, Ruiyang Liu, William J.R. Longabaugh, Teri Longacre, Cynthia X. Ma, Mary Catherine Macedonia, Tyler Madison, Christopher A. Maher, Anirban Maitra, Netta Makinen, Danika Makowski, Carlo Maley, Zoltan Maliga, Diego Mallo, John Maris, Nick Markham, Jeffrey Marks, Daniel Martinez, Robert J. Mashl, Ignas Masilionais, Jennifer Mason, Joan Massagué, Pierre Massion, Marissa Mattar, Richard Mazurchuk, Linas Mazutis, Eliot T. McKinley, Joshua F. McMichael, Daniel Merrick, Matthew Meyerson, Julia R. Miessner, Gordon B. Mills, Meredith Mills, Suman B. Mondal, Motomi Mori, Yuriko Mori, Elizabeth Moses, Yael Mosse, Jeremy L. Muhlich, George F. Murphy, Nicholas E. Navin, Michel Nederlof, Reid Ness, Stephanie Nevins, Milen Nikolov, Ajit Johnson Nirmal, Garry Nolan, Edward Novikov, Brendan O’Connell, Michael Offin, Stephen T. Oh, Anastasiya Olson, Alex Ooms, Miguel Ossandon, Kouros Owzar, Swapnil Parmar, Tasleema Patel, Gary J. Patti, Itsik Pe'er, Tao Peng, Daniel Persson, Marvin Petty, Hanspeter Pfister, Kornelia Polyak, Kamyar Pourfarhangi, Sidharth V. Puram, Qi Qiu, Álvaro Quintanal-Villalonga, Arjun Raj, Marisol Ramirez-Solano, Rumana Rashid, Ashley N. Reeb, Mary Reid, Adam Resnick, Sheila M. Reynolds, Jessica L. Riesterer, Scott Rodig, Joseph T. Roland, Sonia Rosenfield, Asaf Rotem, Sudipta Roy, Charles M. Rudin, Marc D. Ryser, Maria Santi-Vicini, Kazuhito Sato, Deborah Schrag, Nikolaus Schultz, Cynthia L. Sears, Rosalie C. Sears, Subrata Sen, Triparna Sen, Alex Shalek, Jeff Sheng, Quanhu Sheng, Kooresh I. Shoghi, Martha J. Shrubsole, Yu Shyr, Alexander B. Sibley, Kiara Siex, Alan J. Simmons, Dinah S. Singer, Shamilene Sivagnanam, Michal Slyper, Artem Sokolov, Sheng-Kwei Song, Austin Southard-Smith, Avrum Spira, Janet Stein, Phillip Storm, Elizabeth Stover, Siri H. Strand, Timothy Su, Damir Sudar, Ryan Sullivan, Lea Surrey, Mario Suvà, Nadezhda V. Terekhanova, Luke Ternes, Lisa Thammavong, Guillaume Thibault, George V. Thomas, Vésteinn Thorsson, Ellen Todres, Linh Tran, Madison Tyler, Yasin Uzun, Anil Vachani, Eliezer Van Allen, Simon Vandekar, Deborah J. Veis, Sébastien Vigneau, Arastoo Vossough, Angela Waanders, Nikhil Wagle, Liang-Bo Wang, Michael C. Wendl, Robert West, Chi-yun Wu, Hao Wu, Hung-Yi Wu, Matthew A. Wyczalkowski, Yubin Xie, Xiaolu Yang, Clarence Yapp, Wenbao Yu, Yinyin Yuan, Dadong Zhang, Kun Zhang, Mianlei Zhang, Nancy Zhang, Yantian Zhang, Yanyan Zhao, Daniel Cui Zhou, Zilu Zhou, Houxiang Zhu, Qin Zhu, Xiangzhu Zhu, Yuankun Zhu, Xiaowei Zhuang

Publikováno v: Cell

Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ea82738e14282269df985158663c08
https://doi.org/10.1016/j.cell.2020.03.053

HTAPP_Acquisition and allocation of fresh metastatic breast cancer sample. v1

Autor: Karla Helvie, Laura DelloStritto, Lori Marini, Nelly Oliver, Miraj Patel, Sébastien Vigneau, Nikhil Wagle, Asaf Rotem, Bruce Johnson

This standard operating procedure was established by the Center for Cancer Genomics at Dana-Farber Cancer Institute, the Brigham and Women's Hospital and the Klarman Cell Observatory at the Broad Institute, to standardize the collection of fresh meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e578ccbf3a2d052f4afd857822157461
https://doi.org/10.17504/protocols.io.b2fsqbne

Transcriptional mediators of treatment resistance in lethal prostate cancer

Autor: Kevin Bi, Aviv Regev, Laura DelloStritto, Michael S. Cuoco, David Liu, Natalie I. Vokes, Christopher Rodman, Jett Crowdis, Jihye Park, Mei-Ju Su, Sabrina Y. Camp, Meng Xiao He, Orit Rozenblatt-Rosen, Alok K. Tewari, Alice Bosma-Moody, Asaf Rotem, Kelly P. Burke, Lawrence Fong, Zhenwei Zhang, Benjamin Izar, Mary-Ellen Taplin, Sébastien Vigneau, Parin Shah, Abhay Kanodia, Eliezer M. Van Allen, Ziad Bakouny

Metastatic castration resistant prostate cancer (mCRPC) is primarily treated with therapies that prevent transcriptional activity of the androgen receptor (AR), cause DNA damage, or prevent cell division. Clinical resistance to these therapies, inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dc3f3e0daefa20dbd7b9084d7267c9
https://doi.org/10.1101/2020.03.19.998450

Spatially organized multicellular immune hubs in human colorectal cancer

Autor: Sébastien Vigneau, Arlene H. Sharpe, William H. Ge, Toni Delorey, Karin Pelka, Katherine Xu, Angela M. Magnuson, Emma K. Hill, Marios Giannakis, Susannah T. Phillips, Anise S. Applebaum, Lauren K. Brais, Vjola Jorgji, Joshua D. Pirl, Ana C. Anderson, Asaf Rotem, Moshe Biton, David H. Berger, Shuji Ogino, Kimmie Ng, Ofir Cohen, Linda T. Nieman, Max N. Goder-Reiser, Max Klapholz, Genevieve M. Boland, Hiroko Kunitake, Andrew J. Aguirre, Aviv Regev, Tabea Moll, Isaac Wakiro, Dennie T. Frederick, Julia Waldman, Nir Hacohen, Mei-Ju Su, Julia K. Meehan, Ryan B. Corcoran, Benjamin Izar, Abhay Kanodia, David J. Lieb, Matan Hofree, Jason Reeves, Danielle Dionne, Jason Yeung, Vijay K. Kuchroo, Margaret L. Hoang, Thomas E. Clancy, Daniel R. Zollinger, Michael S. Cuoco, Siranush Sarkizova, Lan T. Nguyen, Orit Rozenblatt-Rosen, Sarah L. Denning, Jingyi Wu, Ronald Bleday, Julian Albers, Amitabh Srivastava, Natasha Asinovski, Conner Lambden, Nelya Melnitchouk, Laura DelloStritto, Sherry X. Chao, Ellen Todres, Judit Jané-Valbuena, Alborz Bejnood, Christopher A. Fuhrman, Jason L. Hornick, Jennifer Irani, Bruce E. Johnson, Jonathan H. Chen, Christopher Smillie, Tatyana Sharova, Brinda Vijaykumar

Publikováno v: Cell

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99409d3d491150f7fc84cbaf5ba07cf6
https://doi.org/10.1016/j.cell.2021.08.003