Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Laura DeVault"'
Autor:
Laura DeVault, Chase Mateusiak, John Palucki, Michael Brent, Jeffrey Milbrandt, Aaron DiAntonio
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300539 (2024)
Genetic and pharmacological perturbation of the cytoskeleton enhances the regenerative potential of neurons. This response requires Dual-leucine Zipper Kinase (DLK), a neuronal stress sensor that is a central regulator of axon regeneration and degene
Externí odkaz:
https://doaj.org/article/43b39fdcbbcd4e89a6be7c2cf9545dfb
Publikováno v:
eLife, Vol 11 (2022)
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development. Drosophila melanogaster larvae undergo a behavioral transition by
Externí odkaz:
https://doaj.org/article/bb6fa6b9b23b49e18e9b5d2d3d5be7b6
Publikováno v:
eLife, Vol 10 (2021)
SARM1 is an inducible NAD+ hydrolase that triggers axon loss and neuronal cell death in the injured and diseased nervous system. While SARM1 activation and enzyme function are well defined, the cellular events downstream of SARM1 activity but prior t
Externí odkaz:
https://doaj.org/article/4877f3da02fe49ecbeaf4ea689071126
Autor:
Shan Meltzer, Joshua A. Bagley, Gerardo Lopez Perez, Caitlin E. O’Brien, Laura DeVault, Yanmeng Guo, Lily Yeh Jan, Yuh-Nung Jan
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 859-866 (2017)
Summary: Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are u
Externí odkaz:
https://doaj.org/article/d901711a896c4637ab29b66523841162
Autor:
Kelsey L. Krus, Amy Strickland, Yurie Yamada, Laura Devault, Robert E. Schmidt, A. Joseph Bloom, Jeffrey Milbrandt, Aaron DiAntonio
Publikováno v:
Cell reports. 39(13)
TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most patients with amyotrophic lateral sclerosis (ALS). To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2813a830dfb68a91121f259679668b13
https://pubmed.ncbi.nlm.nih.gov/35767949
https://pubmed.ncbi.nlm.nih.gov/35767949
Publikováno v:
eLife. 11
Sensory neurons enable animals to detect environmental changes and avoid harm. An intriguing open question concerns how the various attributes of sensory neurons arise in development.During their lives, animals encounter a broad range of stimuli from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04808135a3f833aefba1d99ee16d0dfc
https://pubmed.ncbi.nlm.nih.gov/35353036
https://pubmed.ncbi.nlm.nih.gov/35353036
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005484 (2015)
Formation of elaborately branched dendrites is necessary for the proper input and connectivity of many sensory neurons. Previous studies have revealed that dendritic growth relies heavily on ER-to-Golgi transport, Golgi outposts and endocytic recycli
Externí odkaz:
https://doaj.org/article/c697ce442f6844ea9cadd2614c417870
Publikováno v:
Genes & Development. 32:402-414
Dendrites possess distinct structural and functional properties that enable neurons to receive information from the environment as well as other neurons. Despite their key role in neuronal function, current understanding of the ability of neurons to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf36764cffde90d70a9d0b73f246d5b9
https://doi.org/10.1101/gad.308270.117
https://doi.org/10.1101/gad.308270.117