The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis

Autor: Jordi Guiteras, Élia Ripoll, Núria Bolaños, Laura De Ramon, Pere Fontova, Núria Lloberas, Josep Maria Cruzado, Josep Maria Aràn, Anna Aviñó, Ramon Eritja, Montse Gomà, Rosario Taco, Josep Maria Grinyó, Juan Torras

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 807-821 (2021)

Systemic lupus erythematosus is a highly complex and heterogeneous autoimmune disease mostly mediated by B cells. It is characterized by circulating self-reactive antibodies that deposit and form immune complexes in kidney, leading to irreparable tis

Externí odkaz: https://doaj.org/article/74ac3e61a22d442ebac7639caa26d250

Datasets for the validation of the 'in vivo' siRNA-silencing of CD40 and for the detection of new markers of atherosclerosis progression in ApoE-deficient mice

Autor: Miguel Hueso, Laura De Ramon, Estanislao Navarro, Elia Ripoll, Josep M. Cruzado, Josep M. Grinyo, Joan Torras

Publikováno v: Data in Brief, Vol 9, Iss C, Pp 1105-1112 (2016)

Data presented in this Data in Brief article correspond to the article "in vivo" silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclero

Externí odkaz: https://doaj.org/article/035470eff9b3476683396c75ec8c0f67

The Timing of Immunomodulation Induced by Mesenchymal Stromal Cells Determines the Outcome of the Graft in Experimental Renal Allotransplantation

Autor: Ana Merino, Elia Ripoll, Laura De Ramon, Nuria Bolaños, Montserrat Goma, Oriol Bestard, Nuria Lloberas, Josep M. Grinyo, Juan Torras Ambròs

Publikováno v: Cell Transplantation, Vol 26 (2017)

The immunomodulatory characteristics of mesenchymal stromal cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate, first, the effect of the donor-type MSCs from Wistar rats on t

Externí odkaz: https://doaj.org/article/e4d25abca7c54b66a6ab7de7057ae6f3

The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis

Autor: Juan Torras, Montse Gomà, Núria Bolaños, Josep M. Aran, Josep M. Cruzado, Elia Ripoll, Josep M. Grinyó, Jordi Guiteras, Rosario Taco, Ramon Eritja, Laura De Ramon, Nuria Lloberas, Anna Aviñó, Pere Fontova

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 24, Iss, Pp 807-821 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Dipòsit Digital de la UB
Universidad de Barcelona

Systemic lupus erythematosus is a highly complex and heterogeneous autoimmune disease mostly mediated by B cells. It is characterized by circulating self-reactive antibodies that deposit and form immune complexes in kidney, leading to irreparable tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f2ab383b2876b74ac64ebb17d2d646
http://hdl.handle.net/10261/242309

CD40 gene silencing reduces the progression of experimental lupus nephritis modulating local milieu and systemic mechanisms.

Autor: Èlia Ripoll, Ana Merino, Immaculada Herrero-Fresneda, Josep M Aran, Montse Goma, Nuria Bolaños, Laura de Ramon, Oriol Bestard, Josep M Cruzado, Josep M Grinyó, Juan Torras

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65068 (2013)

Lupus nephritis (LN) is an autoimmune disorder in which co-stimulatory signals have been involved. Here we tested a cholesterol-conjugated-anti-CD40-siRNA in dendritic cells (DC) in vitro and in a model of LPS to check its potency and tissue distribu

Externí odkaz: https://doaj.org/article/ddac516d3318448f99213346262285bd