Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laura D. Marrufo"'
Autor:
Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, Sheri L. Bonar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57328f6e5ea96fc972d684f2e92281c
https://doi.org/10.1016/j.bmcl.2011.04.120
https://doi.org/10.1016/j.bmcl.2011.04.120
Autor:
James W. Malecha, Christina N. Steininger, Melanie L. Williams, Kristen E. Shannon, Thomas Rogers, Bryan H. Landis, Tiffany Duffin, Srinivasan Nagarajan, Pegg Jodi Ann, Hwang-Fun Lu, Rico Joseph G, Maureen A. Nickols, Jun Zhu, Sandra K. Freeman, V. Wayne Engleman, David W. Griggs, G. Alan Nickols, Jeffery L. Keene, Devadas Balekudru, Debra M. Meyer, Marisa M. Westlin, Larry Miller, Laura D. Marrufo, Nawasa F. Green, Melissa K. Lantz, Mark A. Russell, Peter G. Ruminski, Mary Beth Finn, H. Peter Kleine, Joe T. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3783-3800
The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034
https://doi.org/10.1016/j.bmc.2007.03.034
Publikováno v:
Organic Process Research & Development. 3:352-356
Polyols such as sorbitol, now directly available from biomass carbohydrates, are reduced by hydriodic acid (HI) to hydrocarbon fuels (80%) with some alkyl halide (20%) according to a new process (eq 1). Incipient iodine (I2) is reduced and returned t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2556e0cb8133035eaa6ec3d684ffc8ce
https://doi.org/10.1021/op990181t
https://doi.org/10.1021/op990181t
Autor:
Rajesh V. Devraj, Heather M. Madsen, Heidi M. Morgan, Laura D. Marrufo, Gary D. Anderson, Shaun R. Selness, Dean Messing, Elizabeth G. Webb, Joseph B. Monahan, Jian Zhang, Devadas Balekudru, Jerry Z. Yang, Huey S. Shieh, Li Xing
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(13)
A novel series of highly potent and selective p38 MAP kinase inhibitors was developed originating from a substituted N-aryl-6-pyrimidinone scaffold. SAR studies coupled with in vivo evaluations in rat arthritis model culminated in the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c50bfd334c3732636cf4d80aaa2300c
https://pubmed.ncbi.nlm.nih.gov/21620699
https://pubmed.ncbi.nlm.nih.gov/21620699
Autor:
Srinivasan R, Nagarajan, Balekudru, Devadas, James W, Malecha, Hwang-Fun, Lu, Peter G, Ruminski, Joseph G, Rico, Thomas E, Rogers, Laura D, Marrufo, Joe T, Collins, H Peter, Kleine, Melissa K, Lantz, Jun, Zhu, Nawasa F, Green, Mark A, Russell, Bryan H, Landis, Lawrence M, Miller, Debra M, Meyer, Tiffany D, Duffin, V Wayne, Engleman, Mary B, Finn, Sandra K, Freeman, David W, Griggs, Melanie L, Williams, Maureen A, Nickols, Jodi A, Pegg, Kristen E, Shannon, Christina, Steininger, Marisa M, Westlin, G Alan, Nickols, Jeffery L, Keene
Publikováno v:
Bioorganicmedicinal chemistry. 15(11)
The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0a0bd91c9e67f6a65c308d5b53b9f248
https://pubmed.ncbi.nlm.nih.gov/17399986
https://pubmed.ncbi.nlm.nih.gov/17399986
Autor:
J. Michael Robinson, Caroline E. Burges, Melissa A. Bently, Chris D. Brasher, Bruce O. Horne, Danny M. Lillard, José M. Macias, Laura D. Marrufo, Hari D. Mandal, Samuel C. Mills, Kevin D. O'Hara, Justin T. Pon, Annette F. Raigoza, Ernesto H. Sanchez, José S. Villarreal, Qian Xiang
Publikováno v:
ACS Symposium Series ISBN: 9780841239340
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::262355a59d375eca41be72a023161998
https://doi.org/10.1021/bk-2006-0921.ch022
https://doi.org/10.1021/bk-2006-0921.ch022
Autor:
Joseph J. Bozell, Martin K. Patel, Jürgen O. Metzger, Ursula Biermann, Detlef Wilke, Yuri Gleba, Leo E. Manzer, Pierre Gallezot, Michèle Besson, Laurent Djakovitch, Alain Perrard, Catherine Pinel, Alexander Sorokin, Dejan D. Andjelkovic, Fengkui Li, Richard C. Larock, Graham J. Hutchings, Silvio Carrettin, Paul McMorn, Patrick Jenkins, Gary A. Attard, Peter Johnston, Ken Griffin, Christopher J. Kiely, J. van Haveren, E. A. Oostveen, F. Miccichè, J. G. J. Weijnen, Scott D. Allen, Christopher M. Byrne, Geoffrey W. Coates, Corey R. Anthony, Lisa McElwee-White, Kevin P. Gable, Brian Ross, Colin P. Horwitz, Terrence J. Collins, Jonathan Spatz, Hayden J. Smith, L. James Wright, Trevor R. Stuthridge, Kathryn G. Wingate, Kim McGrouther, Duncan J. Macquarrie, Jeff J. E. Hardy, Sandrine Hubert, Alexa J. Deveaux, Marco Bandini, Rafael Luque Alvarez, Marie Chabrel, Peter Richard, Ritva Verho, John Londesborough, Merja Penttilä, Thomas M. Keenan, Stuart W. Tanenbaum, James P. Nakas, Arthur J. Stipanovic, Thomas E. Amidon, Gary M. Scott, Vincent Barber, Misty