Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laura D. Jennings-Antipov"'
Publikováno v:
Emerging Topics in Life Sciences
Since the time of Newton and Galileo, the tools for capturing and communicating science have remained conceptually unchanged — in essence, they consist of observations on paper (or electronic variants), followed by a ‘letter’ to the community t
Autor:
Antonius J. A. van Maris, Timothy S. Gardner, Jack Morel, Laura D. Jennings-Antipov, Robert Mans, Jack T. Pronk, Hannes Juergens, Matthijs S. Niemeijer
Publikováno v:
Scientific Data
Scientific Data, 5
Scientific Data, 5
Open data in science requires precise definition of experimental procedures used in data generation, but traditional practices for sharing protocols and data cannot provide the required data contextualization. Here, we explore implementation, in an a
Publikováno v:
Biochemistry
Electrophysiological studies of wild-type and mutated forms of anthrax protective antigen (PA) suggest that the Phe clamp, a structure formed by the Phe427 residues within the lumen of the oligomeric PA pore, binds the unstructured N-terminus of the
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling
Publikováno v:
Proceedings of the National Academy of Sciences. 108:1868-1873
The protective antigen (PA) moiety of anthrax toxin forms oligomeric pores that translocate the enzymatic moieties of the toxin—lethal factor (LF) and edema factor (EF)—across the endosomal membrane of mammalian cells. Here we describe site-direc
Publikováno v:
The Journal of General Physiology
Anthrax toxin consists of three proteins: lethal factor (LF), edema factor (EF), and protective antigen (PA). This last forms a heptameric channel, (PA63)7, in the host cell’s endosomal membrane, allowing the former two (which are enzymes) to be tr
Autor:
Shawdee Eshghi, Yan Zhang, Matthew Onsum, Timothy R Stowe, Bjorn L Millard, Andrea D. Nickerson, Ulrik B. Nielsen, Laura D Jennings-Antipov, Kristopher M. Kuchenbecker
Publikováno v:
Circulation Research. 117
Background: Despite the benefits of reperfusion therapy after myocardial infarction (MI), most patients still progress to heart failure. MI patients suffer irreversible loss of heart function due to cardiomyocyte (CM) death and tissue scarring. Growt
Autor:
Timothy R Stowe, Shawdee Eshghi, Laura D Jennings-Antipov, Yan Zhang, Phung Gip, Matthew D Onsum
Publikováno v:
Circulation Research. 115
Background: Despite the benefits of reperfusion therapy after myocardial infarction (MI), one-year mortality and morbidity rates remain high. Silver Creek Pharmaceuticals is engineering a new class of protein therapeutics, termed Smart Growth Factors