Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Laura D. Attardi"'
Autor:
Clara Morral, Arshad Ayyaz, Hsuan-Cheng Kuo, Mardi Fink, Ioannis I. Verginadis, Andrea R. Daniel, Danielle N. Burner, Lucy M. Driver, Sloane Satow, Stephanie Hasapis, Reem Ghinnagow, Lixia Luo, Yan Ma, Laura D. Attardi, Constantinos Koumenis, Andy J. Minn, Jeffrey L. Wrana, Chang-Lung Lee, David G. Kirsch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ionizing radiation induces cell death in the gastrointestinal (GI) epithelium by activating p53. However, p53 also prevents animal lethality caused by radiation-induced acute GI syndrome. Through single-cell RNA-sequencing of the irradiated
Externí odkaz:
https://doaj.org/article/f8259dde53cf4c8bad036795c5ff982c
Autor:
Bo He, Lauren Stoffel, Clifford Jiajun He, Kumsun Cho, Albert M. Li, Haowen Jiang, Brittany M. Flowers, Kha The Nguyen, Kelly Wen Wang, Audrey Yixin Zhao, Meng-Ning Zhou, Sofia Ferreira, Laura D. Attardi, Jiangbin Ye
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract As a highly heterogeneous tumor, pancreatic ductal adenocarcinoma (PDAC) exhibits non-uniform responses to therapies across subtypes. Overcoming therapeutic resistance stemming from this heterogeneity remains a significant challenge. Here, w
Externí odkaz:
https://doaj.org/article/49624cfd032446e1b3b7c7e99edf32b1
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Autor:
Tan A. Nguyen, Kathryn T. Bieging-Rolett, Tracy L. Putoczki, Ian P. Wicks, Laura D. Attardi, Ken C. Pang
Publikováno v:
iScience, Vol 20, Iss , Pp 14-24 (2019)
Summary: RNautophagy is a newly described type of selective autophagy whereby cellular RNAs are transported into lysosomes for degradation. This process involves the transmembrane protein SIDT2, which transports double-stranded RNA (dsRNA) across the
Externí odkaz:
https://doaj.org/article/6849ae9ab80943549e7585a2addeaeec
Autor:
Natalia Gomez-Ospina, Samantha G. Scharenberg, Nathalie Mostrel, Rasmus O. Bak, Sruthi Mantri, Rolen M. Quadros, Channabasavaiah B. Gurumurthy, Ciaran Lee, Gang Bao, Carlos J. Suarez, Shaukat Khan, Kazuki Sawamoto, Shunji Tomatsu, Nitin Raj, Laura D. Attardi, Laure Aurelian, Matthew H. Porteus
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Mucopolysaccharidosis type I (MPSI) is a lysosomal storage disease caused by insufficient iduronidase (IDUA) activity. Here, the authors use an ex vivo genome editing approach to overexpress IDUA in human hematopoietic stem and progenitor cells and s
Externí odkaz:
https://doaj.org/article/8f066f14a98c44ea90d2d9109e701772
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 3 (2021)
The tumor protein p53 (TP53, best known as p53) transcription factor is a critical tumor suppressor, but those p53-inducible genes most important for tumor suppression have remained unclear. Using unbiased RNA interference and CRISPR (Clustered Regul
Externí odkaz:
https://doaj.org/article/b7744515a0904af087fdd07d770d8420
Autor:
Liz J. Valente, Laura D. Attardi
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cel
Externí odkaz:
https://doaj.org/article/97cd1f591c234a7fb3f506ccefb827f3
Autor:
Amy Tarangelo, Leslie Magtanong, Kathryn T. Bieging-Rolett, Yang Li, Jiangbin Ye, Laura D. Attardi, Scott J. Dixon
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 569-575 (2018)
How cancer cells respond to nutrient deprivation remains poorly understood. In certain cancer cells, deprivation of cystine induces a non-apoptotic, iron-dependent form of cell death termed ferroptosis. Recent evidence suggests that ferroptosis sensi
Externí odkaz:
https://doaj.org/article/65fa87ec72d24c9a89ee70935269d022
Autor:
Robert Durruthy-Durruthy, Ethan D. Sperry, Margot E. Bowen, Laura D. Attardi, Stefan Heller, Donna M. Martin
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The chromatin remodeling protein CHD7 is critical for proper formation of the mammalian inner ear. Humans with heterozygous pathogenic variants in CHD7 exhibit CHARGE syndrome, characterized by hearing loss and inner ear dysplasia, including abnormal
Externí odkaz:
https://doaj.org/article/8827bb90b6e24226bf46d7c43617fe3f
Autor:
Dadi Jiang, Edward L. LaGory, Daniela Kenzelmann Brož, Kathryn T. Bieging, Colleen A. Brady, Nichole Link, John M. Abrams, Amato J. Giaccia, Laura D. Attardi
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1096-1109 (2015)
The p53 tumor suppressor plays a key role in maintaining cellular integrity. In response to diverse stress signals, p53 can trigger apoptosis to eliminate damaged cells or cell-cycle arrest to enable cells to cope with stress and survive. However, th
Externí odkaz:
https://doaj.org/article/83a777ee595942b28dbf89a26e4abbef