Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Laura D, Gamble"'
Autor:
Jayne E. Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J. Gifford, Jamie I. Fletcher, Chengyuan Xue, Nisitha Jayatilleke, Firoozeh Salehzadeh, Laura D. Gamble, Jourdin R. C. Rouaen, Daniel R. Carter, Helen Forgham, Eric O. Sekyere, Joanna Keating, Georgina Eden, Sophie Allan, Stephanie Alfred, Frances K. Kusuma, Ashleigh Clark, Hannah Webber, Amanda J. Russell, Antoine de Weck, Benjamin T. Kile, Martina Santulli, Piergiuseppe De Rosa, Emmy D. G. Fleuren, Weiman Gao, Lorna Wilkinson-White, Jason K. K. Low, Joel P. Mackay, Glenn M. Marshall, Douglas J. Hilton, Federico M. Giorgi, Jan Koster, Giovanni Perini, Michelle Haber, Murray D. Norris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcript
Externí odkaz:
https://doaj.org/article/ee532e0c05a8415d9de099a04d9f475c
Autor:
Anthony Martyr, Laura D. Gamble, Anna Hunt, Catherine Quinn, Robin G. Morris, Catherine Henderson, Louise Allan, Carol Opdebeeck, Catherine Charlwood, Roy W. Jones, Claire Pentecost, Michael D. Kopelman, Jeanette M. Thom, Fiona E. Matthews, Linda Clare
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time. Methods The parti
Externí odkaz:
https://doaj.org/article/5468617eb13d43c980af2a4b108549d0
Autor:
Serena Sabatini, Anthony Martyr, Anna Hunt, Laura D. Gamble, Fiona E. Matthews, Jeanette M. Thom, Roy W. Jones, Louise Allan, Martin Knapp, Catherine Quinn, Christina Victor, Claire Pentecost, Jennifer M. Rusted, Robin G. Morris, Linda Clare
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Objectives Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two year
Externí odkaz:
https://doaj.org/article/a41a33f69e2244a8b42e79a01429d45d
Autor:
Serena Sabatini, Anthony Martyr, Anna Hunt, Laura D. Gamble, Fiona E. Matthews, Jeanette M. Thom, Roy W. Jones, Louise Allan, Martin Knapp, Christina Victor, Claire Pentecost, Jennifer M. Rusted, Robin G. Morris, Linda Clare
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in num
Externí odkaz:
https://doaj.org/article/4aee1064c0fe4c96b755d9d044489ce4
Autor:
Anthony Martyr, Jennifer M. Rusted, Catherine Quinn, Laura D. Gamble, Rachel Collins, Robin G. Morris, Linda Clare
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Objectives A novel model of resilience was tested in caregivers of people with mild-to-moderate dementia and was extended to explore whether including self-efficacy, optimism, and self-esteem improved its predictive value. Design Cross-secti
Externí odkaz:
https://doaj.org/article/c5bbb1a3a5974cc1a5fea1d8a03e42e1
Autor:
Anna Hunt, Anthony Martyr, Laura D. Gamble, Robin G. Morris, Jeanette M. Thom, Claire Pentecost, Linda Clare
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Cross-sectional evidence indicates that certain personality traits may influence how well people with dementia and their caregivers are able to live alongside the condition. However, no studies to date have explored these associat
Externí odkaz:
https://doaj.org/article/6ee7192a45c14307a7f433e2156f73d9
Autor:
Catherine M. Alexander, Anthony Martyr, Laura D. Gamble, Catherine Quinn, Claire Pentecost, Robin G. Morris, Linda Clare
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionThe discrepancy between caregiver-ratings and self-ratings of abilities is commonly used to assess awareness in people with dementia. We investigated the contribution of caregiver and dyadic characteristics to the difference in perspectiv
Externí odkaz:
https://doaj.org/article/8cc44a6e6373439b88660c7f1a492948
Autor:
Laura D. Gamble, Fiona E. Matthews, Ian R. Jones, Alex E. Hillman, Bob Woods, Catherine A. Macleod, Anthony Martyr, Rachel Collins, Claire Pentecost, Jennifer M. Rusted, Linda Clare
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Many people living with dementia remain undiagnosed, with diagnosis usually occurring long after signs and symptoms are present. A timely diagnosis is important for the wellbeing of the person living with dementia and the family,
Externí odkaz:
https://doaj.org/article/edfa93ec0a934f1c8488acc34f67cbec
Autor:
Catherine M. Alexander, Anthony Martyr, Laura D. Gamble, Sharon A. Savage, Catherine Quinn, Robin G. Morris, Rachel Collins, Linda Clare, in collaboration with the IDEAL programme research team
Publikováno v:
BMC Geriatrics, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background People living with dementia vary in awareness of their abilities. We explored awareness of the condition and diagnosis in people with mild-to-moderate dementia, and how this relates to quality of life, well-being, life satisfactio
Externí odkaz:
https://doaj.org/article/a1a9911a8ac74e8fbb052fea99245b38
Autor:
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in
Externí odkaz:
https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8