Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laura Conesa-Milián"'
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these designed molecules display a urea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60dfaed2376a654c0a825c8e6f5d8e93
https://doi.org/10.1016/j.ejmech.2019.03.012
https://doi.org/10.1016/j.ejmech.2019.03.012
Publikováno v:
European Journal of Medicinal Chemistry. 162:781-792
Twenty-six compounds derived from 3′-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative activity of all the synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d72760a4c7fce15952e5f0b362dd4b1
https://doi.org/10.1016/j.ejmech.2018.11.023
https://doi.org/10.1016/j.ejmech.2018.11.023
Autor:
Eva Falomir, Miguel Carda, Sam Noppen, Sandra Liekens, Juan Murga, Laura Conesa-Milián, Juan Alberto Marco, Ana Marzo-Mas
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
Background: In the last years, many efforts have been made to find colchicine derivatives with reduced toxicity. Additionally, the deregulation of amino acid uptake by cancer cells provides an opportunity to improve anticancer drug effectiveness. Obj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d335f9898b08bbd26b15aca56200b0
Autor:
Juan Carlos Coa, Wilson Cardona-G, Andrés F. Yepes, Sara M. Robledo, Yulieth Upegui, Laura Conesa-Milián, Miguel Carda
Publikováno v:
Repositori Universitat Jaume I
instname
instname
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da664c97a1db12b06352ecf5672837c7
http://hdl.handle.net/10234/187520
http://hdl.handle.net/10234/187520
Autor:
Laura Conesa-Milián, Iván D. Vélez, Isabel Vásquez, Miguel Carda, Elisa García, Rodrigo Ochoa, Wilson Cardona-G, Andrés F. Yepes, Sara M. Robledo
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
The synthesis, antitrypanosomal, and cytotoxic activities of 17 furanchalcone derivatives are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The synthesized compounds were evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67032d2a3f44b822e5b99760aa06c246
https://doi.org/10.1007/s00044-019-02323-7
https://doi.org/10.1007/s00044-019-02323-7
Autor:
Miguel Carda, Eva Falomir, Laura Conesa-Milián, J. Alberto Marco, María Sánchez-Peris, Celia Martín-Beltrán, Juan Murga
Publikováno v:
Bioorganicmedicinal chemistry. 27(5)
Twenty-four derivatives structurally related to honokiol have been synthesized and biologically evaluated. IC50 values were determined towards the HT-29, MCF-7 and HEK-293 cell lines. Some of these derivatives exhibited comparable or lower IC50 value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26748c7ea0436cfa4e44dee56053ae16
https://pubmed.ncbi.nlm.nih.gov/30733086
https://pubmed.ncbi.nlm.nih.gov/30733086
Autor:
Juan Murga, J. Alberto Marco, Eva Falomir, Eef Meyen, Laura Conesa-Milián, Miguel Carda, Sandra Liekens
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
A series of t wenty-six carbamates derived from aminocombretastatin A- 4 (AmCA-4 ) were syn thesized and evaluated for their capacity to affect cell proliferation, tubulin polymerization, mitotic cell arrest, microtubule network organization, apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8084f759aa4d3b89ffad29d2e36c21d
https://pubmed.ncbi.nlm.nih.gov/29432949
https://pubmed.ncbi.nlm.nih.gov/29432949