Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laura Codarri-Deak"'
Autor:
Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Next-generation cancer immunotherapies are designed to broaden the therapeutic repertoire by targeting new immune checkpoints including lymphocyte-activation gene 3 (LAG-3) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3). Y
Externí odkaz:
https://doaj.org/article/d05c988c40044c0488968cfb22947d69
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe immunocytokine PD1-IL2v was designed to overcome liabilities and improve efficacy of IL-2 therapies. PD1-IL2v preferentially targets PD-1+ T-cells and acts on antigen-specific stem-like PD-1+ TCF-1+ CD8+ T-cells expanding and differentiat
Externí odkaz:
https://doaj.org/article/309d650fc20346a19de0ef750266fa1d
Autor:
Pedro Romero, Sara Labiano, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Laura Codarri Deak, Genrich V Tolstonog
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/08253d24500e48a49285cd374f5520ca
Autor:
Maureen Hoen, Miles Piper, Laurel B. Darragh, Diemmy Nugyen, Jacob Gadwa, Maria Amann, Greta Durini, Michael Knitz, Benjamin Van Court, Tiffany Pham, Ross Kedl, Pablo Umana, Laura Codarri-Deak, Christian Klein, Angelo D’Alessandro, Sana D. Karam
Publikováno v:
Cancer Research. 83:5106-5106
Although IL-2 has been shown to critically mediate NK and T cell effector functions, when used in clinical trials this cytokine has failed due to toxicity and severe side effects of the systemic treatment. Our lab has investigated the use of a next-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37abe36f8da96c73b08b8150399a2940
https://doi.org/10.1158/1538-7445.am2023-5106
https://doi.org/10.1158/1538-7445.am2023-5106
Autor:
Judith Strauss, Diana Reckendorfer, Kimberly Pojar, Laura Codarri Deak, Valeria Nicolini, Roger Sutmuller, Christian Klein, Pablo Umaña, Klaus K. Orlinger, Henning Lauterbach
Publikováno v:
Cancer Research. 83:5747-5747
It is undisputed that CD8 T cells play a critical role in controlling tumor growth and killing tumor cells, and that tumor specific T cells are essential for clinical responses to immune checkpoint inhibitors. Yet, the induction and maintenance of fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ce1e5efba4e9802332c12e09991dc67
https://doi.org/10.1158/1538-7445.am2023-5747
https://doi.org/10.1158/1538-7445.am2023-5747
Publikováno v:
Blood. 140:8835-8836
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527ded81610af5e3dedaa77cf9e160d8
https://doi.org/10.1182/blood-2022-167853
https://doi.org/10.1182/blood-2022-167853
Autor:
Mélanie Tichet, Stephan Wullschleger, Agnieszka Chryplewicz, Nadine Fournier, Rachel Marcone, Annamaria Kauzlaric, Krisztian Homicsko, Laura Codarri Deak, Pablo Umaña, Christian Klein, Douglas Hanahan
Publikováno v:
Immunity. 56:162-179.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46161f7fbaefebba8de063c088d1b37d
https://doi.org/10.1016/j.immuni.2022.12.006
https://doi.org/10.1016/j.immuni.2022.12.006
Autor:
Maria Karagianni, Eleni Maria Varypataki, Valeria Nicolini, Christian Münz, Pablo Umana, Christian Klein, Laura Codarri Deak
Publikováno v:
Cancer Research. 82:2070-2070
PD1-IL2v is a novel immunocytokine constituted by a high affinity bivalent blocking PD-1 antibody and a heterodimeric silent Fc-part fused to a monomeric IL-2 variant (IL2v). In contrast to wildtype IL2, IL2v does not bind to CD25 (IL2Ra) and, theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3312774800cc0e0dd6ee859c07ce1f3
https://doi.org/10.1158/1538-7445.am2022-2070
https://doi.org/10.1158/1538-7445.am2022-2070
Autor:
Sara Colombetti, Volker Teichgräber, Anne Freimoser-Grundschober, Leo Kunz, Stefan Seeber, Johannes Sam, Marine Richard, Petra Petra Schwalie, Esther Bommer, Stephane Leclair, Laura Codarri Deak, Pablo Umana, Sylvia Herter, Ramona Schlenker, Vinko Tosevski, Mario Perro, Laura Lauener, Christian Klein, Nicolini Valeria G, Marisa Mariani, Masao Hashimoto, Marina Bacac, Rafi Ahmed, Floriana Cremasco, Maria Karagianni, Inja Waldhauer
Expansion of antigen-specific effector CD8 T cells is central to the control of chronic viral infections and cancer. In particular, differentiation of antigen-experienced, PD-1+TCF-1+ stem -like CD8 T cells, termed here “resource T cells”, into e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5abe852d1c63ede5977b6d210132fa9
https://doi.org/10.21203/rs.3.rs-329812/v1
https://doi.org/10.21203/rs.3.rs-329812/v1
Autor:
Laura, Codarri Deak, Valeria, Nicolini, Masao, Hashimoto, Maria, Karagianni, Petra C, Schwalie, Laura, Lauener, Eleni Maria, Varypataki, Marine, Richard, Esther, Bommer, Johannes, Sam, Stefanie, Joller, Mario, Perro, Floriana, Cremasco, Leo, Kunz, Emilio, Yanguez, Tamara, Hüsser, Ramona, Schlenker, Marisa, Mariani, Vinko, Tosevski, Sylvia, Herter, Marina, Bacac, Inja, Waldhauer, Sara, Colombetti, Xavier, Gueripel, Stephan, Wullschleger, Melanie, Tichet, Douglas, Hanahan, Haydn T, Kissick, Stephane, Leclair, Anne, Freimoser-Grundschober, Stefan, Seeber, Volker, Teichgräber, Rafi, Ahmed, Christian, Klein, Pablo, Umaña
Publikováno v:
Nature. 610(7930)
Expansion and differentiation of antigen-experienced PD-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fb3f4c428392bd3016c698d1d939123
https://pubmed.ncbi.nlm.nih.gov/36171284
https://pubmed.ncbi.nlm.nih.gov/36171284