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Data from Regulation of Replicative and Stress-Induced Senescence by RSK4, which is Down-regulated in Human Tumors

Autor: Santiago Ramon y Cajal, Inés de Torres, Javier Hernández-Losa, Matilde Lleonart, Elisabet Argelaguet, Laura Coch, Berta Pons, Gemma Armengol, Laura López-Vicente

Purpose: The control of senescence and its biochemical pathways is a crucial factor for understanding cell transformation. In a large RNA interference screen, the RSK4 gene was found to be related to p53-dependent arrest. The purpose of the present s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2ecd49b49f2a9bf1b97191d0ba71d3
https://doi.org/10.1158/1078-0432.c.6517335.v1

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Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

Autor: Marc Mejias, Ester Garcia-Pras, Laura Coch, Jaime Bosch, Javier Gallego, Mercedes Fernandez, Raúl Méndez, Annalisa Berzigotti

Publikováno v: Hepatology. 60:633-647

Pathological angiogenesis represents a critical hallmark for chronic liver diseases. Understanding the mechanisms regulating angiogenesis is essential to develop new therapeutic strategies that specifically target pathological angiogenesis without af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223ab65dabc0e11104121d0f84030384
https://doi.org/10.1002/hep.26995

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Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Autor: Jaime Bosch, Javier Gallego, Ester Garcia-Pras, Marc Mejias, Laura Coch, Mercedes Fernandez, Annalisa Berzigotti

Publikováno v: Gut. 64:657-666

Objective Antiangiogenic strategies have been proposed as a promising new approach for the therapy of portal hypertension and chronic liver disease. Pigment epithelium-derived factor (PEDF) is a powerful endogenous angiogenesis inhibitor whose role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ead4ce1c0e50787ccc24688ee912800
https://doi.org/10.1136/gutjnl-2014-307138

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Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

Autor: Gonzalo Fernández-Miranda, Jaime Bosch, Mercedes Fernandez, Ester Garcia-Pras, Raúl Méndez, Javier Gallego, Ricardo Pardal, Marc Mejias, Laura Coch

Publikováno v: Gut. 66(7)

Objective Pathological neovascularisation is intimately involved in portal hypertension (PH). Here, we determined the contribution of vascular stem/progenitor cells (VSPCs) to neovessel growth in PH and whether the RNA-binding protein cytoplasmic pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1f9cf794002d3c4b077e5f51199810
https://pubmed.ncbi.nlm.nih.gov/26984852

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dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes

Autor: Camille Stephan-Otto Attolini, Ivan Garcia-Bassets, Oscar Reina, Roman Kessler, Laura Coch, Fernando Azorín, Joan Font-Burgada, Johan Tisserand

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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© 2015 Macmillan Publishers Limited. All rights reserved. dDsk2 is a conserved extraproteasomal ubiquitin receptor that targets ubiquitylated proteins for degradation. Here we report that dDsk2 plays a nonproteolytic function in transcription regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f205b56f5e720b4d11844692e5678b
https://pubmed.ncbi.nlm.nih.gov/25916810

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The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model

Autor: María Ángeles Vázquez-Sánchez, Elisabet Argelaguet, Laura Coch, Berta Pons, Laura López-Vicente, A. Martínez, Gemma Armengol, Vicente Peg, Santiago Ramón y Cajal, Javier Hernández-Losa

Publikováno v: International Journal of Oncology.

Cell signaling pathways and protein translation are crucial for understanding malignant transformation. 4E-BP1 and the eIF4F complex regulate cap-dependent translation. We investigated how 4E-BP1 and eIF4E phosphorylation status affects in vitro and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac5ea112a021b01c83b3a4827ea1d61
https://doi.org/10.3892/ijo.2011.1118

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Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells

Autor: Santiago Ramón y Cajal, Laura Coch, Laura Cecilia López, Gemma Armengol, Mark Livingstone, Berta Pons, Nahum Sonenberg

Publikováno v: Oncology reports. 27(1)

Translational control is a crucial component of cancer development and progression. Eukaryotic initiation factor (eIF) 4E mediates eIF4F association with the mRNA 5' cap structure to stimulate cap-dependent translation initiation. The eIF4E-binding p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168984c7355391b47de98b52461727eb
https://pubmed.ncbi.nlm.nih.gov/21922152

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RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence

Autor: Laura Coch, Santiago Ramón y Cajal, Laura López-Vicente, Cristina Teixidó, Gemma Armengol, Berta Pons, Javier Hernández-Losa

Publikováno v: Carcinogenesis. 32(4)

p90 Ribosomal S6 kinase (RSK) 4 is a serine―threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS―mitogen-activated protein kinase (MAPK)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310326f4b1dfde0466bbddc2362ffb86
https://pubmed.ncbi.nlm.nih.gov/21239520

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Akademický článek

β-Phosphonated Glycine Pendant Groups Grafted on Styrene-6.7% Divinylbenzene Copolymers: Synthesis and Their Application as Photocatalysts

Autor: Adriana Popa, Laura Cocheci, Lavinia Lupa, Aniela Pop, Aurelia Visa

Publikováno v: Applied Sciences, Vol 13, Iss 3, p 2025 (2023)

Environmental pollution from organic contaminants caused by textile dyeing is a real danger. Wastewater from the textile industry has high organic loads, as well as dyes and chemical compounds used in their preparation. Among the azo dyes, Congo red

Externí odkaz: https://doaj.org/article/660714a08850408a8daf82b00d333ba4

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