Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Laura Cisar"'
Publikováno v:
Journal of Oncology Pharmacy Practice. 24:574-583
Purpose The purpose is to describe management of adverse events of special interest across tyrosine kinase inhibitors approved for metastatic renal cell carcinoma. Methods We conducted a retrospective chart review in metastatic renal cell carcinoma p
Autor:
Jamal Tarazi, Subramanian Hariharan, Thomas E. Hutson, M. Dror Michaelson, Laura Cisar, Angel H. Bair, Yoshihiko Tomita, Brad Rosbrook, Mayer Fishman, Brian I. Rini, Eric Jonasch, Victor Gruenwald
Publikováno v:
Targeted Oncology. 12:333-340
We conducted a retrospective analysis of two clinical trials in treatment-naïve patients (n = 402) with advanced renal cell carcinoma (RCC) treated with axitinib. Our objective was to compare duration of treatment (DT) and clinical outcome in patien
Publikováno v:
Future oncology (London, England). 13(15)
Aim: To study patient characteristics and treatment patterns in real-world axitinib use for metastatic renal cell carcinoma. Patients & methods: We conducted a retrospective analysis of second- or third-line axitinib use between 1 January 2012 and 31
Autor:
Robert J. Motzer, Michael S. Baum, Jamal Tarazi, Laura Cisar, W. Gregory Roberts, Lillian Shahied Arruda, Sinil Kim, David I. Quinn, Laura S. Wood, Brian I. Rini, Brad Rosbrook
Publikováno v:
Targeted Oncology
Inhibitors of the vascular endothelial growth factor (VEGF) pathway frequently induce hypertension when used to treat patients with advanced renal cell carcinoma (RCC). This analysis characterizes hypertension and hypertension-related events in patie
Publikováno v:
Journal of managed carespecialty pharmacy. 22(8)
Sunitinib and pazopanib are among the most prescribed targeted therapies for the systemic management of advanced renal cell carcinoma (RCC), but published cost comparisons between the 2 agents are few and limited by methodological and population diff
Publikováno v:
Journal of managed carespecialty pharmacy. 22(6)
Axitinib is approved by the FDA for the treatment of advanced renal cell carcinoma (RCC) after failure of 1 previous systemic therapy and is distributed primarily through specialty pharmacies. Although the efficacy and safety of axitinib have been es
Publikováno v:
Archives of Drug Information. 1:97-106
Purpose. Statistical models for predicting hematologic toxicity were evaluated based on UGT1A1 polymorphisms and baseline serum bilirubin. Methods. Blood DNA samples were collected from 113 patients with untreated metastatic colorectal cancer receivi
Autor:
Daniel Orbach, Christophe Bergeron, Jean Claude Gentet, Gilles Vassal, Susan Picton, Birgit Geoerger, Anne Geoffray, Bruce Morland, Elizabeth Stockdale, Dominique Couanet, Sylvie Assadourian, Fabienne Pichon, Laura Cisar
Publikováno v:
Journal of Clinical Oncology. 25:356-361
Purpose This phase II study was designed to evaluate the efficacy of irinotecan administered intravenously once every 3 weeks in pediatric patients with recurrent or refractory rhabdomyosarcoma. Patients and Methods A total of 35 patients younger tha
Autor:
Richard M. Goldberg, Gabriela Gruia, Gary Elfring, Mace L. Rothenberg, Rakesh Goel, Donghua Yin, Larry J. Schaaf, Lisa A. Hammond, Stuart J. Tipping, Barbara A. Duncan, Linda D. Compton, J. Patrick McGovren, Langdon L. Miller, Amarnath Sharma, John G. Kuhn, Nicoletta Pirotta, Laura Cisar
Publikováno v:
Clinical Cancer Research. 12:3782-3791
Purpose: To determine the recommended starting doses and pharmacokinetics of irinotecan in cancer patients with impaired liver function treated on a weekly schedule. Experimental Design: Patients with solid tumors who had impaired liver function were
Autor:
Laura Cisar, Nicoletta Orlando, Mark R. Green, Wilson H. Miller, Langdon L. Miller, Caio Max S. Rocha Lima, Adele Morganti, Gabriela Gruia, G. Mark Jeffrey, Robert Rotche
Publikováno v:
Journal of Clinical Oncology. 22:3776-3783
Purpose This phase III, randomized, open-label, multicenter study compared the overall survival associated with irinotecan plus gemcitabine (IRINOGEM) versus gemcitabine monotherapy (GEM) in patients with chemotherapy-naive, locally advanced or metas