Výsledky vyhledávání - "Laura Cianfruglia"

Akademický článek

Glyoxalase 2: Towards a Broader View of the Second Player of the Glyoxalase System

Autor: Andrea Scirè, Laura Cianfruglia, Cristina Minnelli, Brenda Romaldi, Emiliano Laudadio, Roberta Galeazzi, Cinzia Antognelli, Tatiana Armeni

Publikováno v: Antioxidants, Vol 11, Iss 11, p 2131 (2022)

Glyoxalase 2 is a mitochondrial and cytoplasmic protein belonging to the metallo-β-lactamase family encoded by the hydroxyacylglutathione hydrolase (HAGH) gene. This enzyme is the second enzyme of the glyoxalase system that is responsible for detoxi

Externí odkaz: https://doaj.org/article/0429174da0fd4e7086f62472ee329ff5

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Akademický článek

Cushing Syndrome: The Role of MSCs in Wound Healing, Immunosuppression, Comorbidities, and Antioxidant Imbalance

Autor: Miriam Caffarini, Tatiana Armeni, Pamela Pellegrino, Laura Cianfruglia, Marianna Martino, Annamaria Offidani, Giovanni Di Benedetto, Giorgio Arnaldi, Anna Campanati, Monia Orciani

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 7 (2019)

Cushing syndrome (CS), caused by glucocorticoid (GCs) excess, is strictly connected to onset of different metabolic diseases and impaired wound healing. The source of excessively high levels of GCs allows the identification of endogenous and exogenou

Externí odkaz: https://doaj.org/article/188def31074047b2aa38b7d7ee302a04

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Akademický článek

Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation

Autor: Lidia de Bari, Andrea Scirè, Cristina Minnelli, Laura Cianfruglia, Miklos Peter Kalapos, Tatiana Armeni

Publikováno v: Antioxidants, Vol 10, Iss 1, p 19 (2020)

Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence of nutrient catabolism. The balance between ROS production and elimination allows to maintain cell redox homeostasis and biological functions, avoiding the occurr

Externí odkaz: https://doaj.org/article/e84bea2c5ef74b429f77d69dfb712ae9

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Akademický článek

Protection of Polyphenols against Glyco-Oxidative Stress: Involvement of Glyoxalase Pathway

Autor: Laura Cianfruglia, Camilla Morresi, Tiziana Bacchetti, Tatiana Armeni, Gianna Ferretti

Publikováno v: Antioxidants, Vol 9, Iss 10, p 1006 (2020)

Chronic high glucose (HG) exposure increases methylglyoxal (MGO)-derived advanced glycation end-products (AGEs) and is involved in the onset of pathological conditions, such as diabetes, atherosclerosis and chronic-degenerative diseases. Under physio

Externí odkaz: https://doaj.org/article/b775f146d4b04684abd20ddda0797988

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Akademický článek

Side Effects of Curcumin: Epigenetic and Antiproliferative Implications for Normal Dermal Fibroblast and Breast Cancer Cells

Autor: Laura Cianfruglia, Cristina Minnelli, Emiliano Laudadio, Andrea Scirè, Tatiana Armeni

Publikováno v: Antioxidants, Vol 8, Iss 9, p 382 (2019)

Background: Curcumin is a yellow-orange pigment obtained from the plant Curcuma longa, which is known to exert beneficial effects in several diseases, including cancer. However, at high doses, it may produce toxic and carcinogenic effects in normal c

Externí odkaz: https://doaj.org/article/8ae2b0c1d3df4fbeba33c975b8b68666

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Akademický článek

KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins

Autor: Laura Cianfruglia, Andrea Perrelli, Claudia Fornelli, Alessandro Magini, Stefania Gorbi, Anna Maria Salzano, Cinzia Antognelli, Francesca Retta, Valerio Benedetti, Paola Cassoni, Carla Emiliani, Giovanni Principato, Andrea Scaloni, Tatiana Armeni, Saverio Francesco Retta

Publikováno v: Antioxidants, Vol 8, Iss 1, p 27 (2019)

Loss-of-function mutations in the KRIT1 gene are associated with the pathogenesis of cerebral cavernous malformations (CCMs), a major cerebrovascular disease still awaiting therapies. Accumulating evidence demonstrates that KRIT1 plays an important r

Externí odkaz: https://doaj.org/article/25be907905c1464c8f1b05aaaeb7ccee

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