Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Laura C. Van Eyndhoven"'
Autor:
Laura C. Van Eyndhoven, Eleni Chouri, Catarina I. Matos, Aridaman Pandit, Timothy R. D. J. Radstake, Jasper C. A. Broen, Abhyudai Singh, Jurjen Tel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe innate immune system serves the crucial first line of defense against a wide variety of potential threats, during which the production of pro-inflammatory cytokines IFN-I and TNFα are key. This astonishing power to fight invaders, ho
Externí odkaz:
https://doaj.org/article/dade0486bfd640f4b651cf7630cdf252
Publikováno v:
eLife, Vol 12 (2023)
Type I interferon (IFN-I)-mediated antiviral responses are central to host defense against viral infections. Crucial is the tight and well-orchestrated control of cellular decision-making leading to the production of IFN-Is. Innovative single-cell ap
Externí odkaz:
https://doaj.org/article/b3d5f3a727584ff3aa34dc6d65e9fdab
Autor:
Nikita Subedi, Laura C. Van Eyndhoven, Ayla M. Hokke, Lars Houben, Mark C. Van Turnhout, Carlijn V. C. Bouten, Klaus Eyer, Jurjen Tel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cytotoxicity is a vital effector mechanism used by immune cells to combat pathogens and cancer cells. While conventional cytotoxicity assays rely on averaged end-point measures, crucial insights on the dynamics and heterogeneity of effector
Externí odkaz:
https://doaj.org/article/87160ca70d764539bc92b8e660f8164f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Plasmacytoid dendritic cells (pDCs) are a rare type of highly versatile immune cells that besides their specialized function of massive type I interferon (IFN-I) production are able to exert cytotoxic effector functions. However, diversification upon
Externí odkaz:
https://doaj.org/article/43aa5e1a53c84100abbf0d9173b11db4
SUMMARYType-I interferon (IFN-I) subtypes signal through the same IFNα receptor (IFNAR), and initiate temporal STAT1/2 activation to orchestrate innate and adaptive immunity. It remains unknown how IFNAR discriminates between subtypes (e.g., IFNα a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e0e1905b6a262cf3524a142c44c31a
https://doi.org/10.1101/2023.03.27.534340
https://doi.org/10.1101/2023.03.27.534340
Autor:
Nikita Subedi, Liesbeth Petronella Verhagen, Paul de Jonge, Laura C. Van Eyndhoven, Mark C. van Turnhout, Vera Koomen, Jean Baudry, Klaus Eyer, Harry Dolstra, Jurjen Tel
Publikováno v:
Advanced Biology, 7 (4)
Advanced Biology, 7(4):2200207. Wiley
Advanced Biology, 7, 4
Advanced Biology, 7(4):2200207. Wiley
Advanced Biology, 7, 4
Increasing evidence suggests that natural killer (NK) cells are composed of distinct functional subsets. This multifunctional role has made them an attractive choice for anticancer immunotherapy. A functional NK cell repertoire is generated through c
Publikováno v:
eLife, 12:e83055. eLife Sciences Publications
Type I Interferon (IFN-I)-mediated antiviral responses are central to host defense against viral infections. Crucial is the tight and well-orchestrated control of cellular decision-making leading to the production of IFN-Is. Innovative single-cell ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5798c03392280c849ad3c24e578b2b71
https://doi.org/10.1101/2022.09.11.507479
https://doi.org/10.1101/2022.09.11.507479
Autor:
Laura C. Van Eyndhoven, Jurjen Tel
Publikováno v:
European journal of immunologyReferences. 52(12)
Moving from the optimalization of single-cell technologies to the interpretation of the multi-complex single-cell data, the field of immunoengineering is granted with numerous important insights into the coordination of immune cell activation and how
Autor:
Ayla M. Hokke, Klaus Eyer, Jurjen Tel, Nikita Subedi, Carlijn V. C. Bouten, Laura C. Van Eyndhoven, Lars Houben, Mark C. van Turnhout
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, 11(1):17084. Nature Publishing Group
Scientific Reports, 11 (1)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, 11(1):17084. Nature Publishing Group
Scientific Reports, 11 (1)
Cytotoxicity is a vital effector mechanism used by immune cells to combat pathogens and cancer cells. While conventional cytotoxicity assays rely on averaged end-point measures, crucial insights on the dynamics and heterogeneity of effector and targe