Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Laura C. Greaves"'
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3276-3294 (2022)
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective g
Externí odkaz:
https://doaj.org/article/c6e193cc62b14a09a7f03a51ece490a6
Autor:
Ashwin Sachdeva, Claire A. Hart, Christopher D. Carey, Amy E. Vincent, Laura C. Greaves, Rakesh Heer, Pedro Oliveira, Michael D. Brown, Noel W. Clarke, Doug M. Turnbull
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Advances in multiplex immunofluorescence (mIF) and digital image analysis has enabled simultaneous assessment of protein defects in electron transport chain components. However, current manual methodology is time consuming and labour intensi
Externí odkaz:
https://doaj.org/article/e3358b5729ea406d9a319d06fa673144
Autor:
Craig Stamp, Anze Zupanic, Ashwin Sachdeva, Elizabeth A. Stoll, Daryl P. Shanley, John C. Mathers, Thomas B.L. Kirkwood, Rakesh Heer, Benjamin D. Simons, Doug M. Turnbull, Laura C. Greaves
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 166-173 (2018)
Stem cell (SC) dynamics within the human colorectal crypt SC niche remain poorly understood, with previous studies proposing divergent hypotheses on the predominant mode of SC self-renewal and the rate of SC replacement. Here we use age-related mitoc
Externí odkaz:
https://doaj.org/article/9bda2126e811423486831f94b1e0f2ba
Autor:
Johanna H.K. Kauppila, Holly L. Baines, Ana Bratic, Marie-Lune Simard, Christoph Freyer, Arnaud Mourier, Craig Stamp, Roberta Filograna, Nils-Göran Larsson, Laura C. Greaves, James B. Stewart
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2980-2990 (2016)
Mutations of mtDNA are an important cause of human disease, but few animal models exist. Because mammalian mitochondria cannot be transfected, the development of mice with pathogenic mtDNA mutations has been challenging, and the main strategy has the
Externí odkaz:
https://doaj.org/article/c9d60e6d715741ada477ce9887a88f10
Publikováno v:
Molecular Oncology. 16:3276-3294
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa8f5079c504a580d79e8b89138bd20
https://doi.org/10.1002/1878-0261.13291
https://doi.org/10.1002/1878-0261.13291
Autor:
Tianhong Su, Tiago M Bernardino Gomes, Anna L M Smith, Julia C Whitehall, Alasdair P Blain, Marie-Lune Simard, Louisa Scholten, James B Stewart, Doug M Turnbull, Conor Lawless, Laura C Greaves
Mitochondrial DNA (mtDNA) mutations accumulate in both mitotic and post-mitotic somatic tissues of normal individuals with age. They clonally expand within individual cells and cause mitochondrial dysfunction. In contrast, in patients with inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb6633bc84b8031c2a5207f2b1455c0
https://doi.org/10.1101/2023.04.06.535821
https://doi.org/10.1101/2023.04.06.535821
Publikováno v:
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science ISBN: 9783031214097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0184c5d3e02d64a12ccd8a1ec8f6a7d4
https://doi.org/10.1007/978-3-031-21410-3_4
https://doi.org/10.1007/978-3-031-21410-3_4
Autor:
Xuefei Yu, Catherine Arden, Rolando Berlinguer-Palmini, Chun Chen, Carla Bradshaw, Anna LM Smith, Julia Whitehall, Michael White, Scott Anderson, Nicole Kattner, James Shaw, Doug Turnbull, Laura C Greaves, Mark Walker
Publikováno v:
Molecular metabolism. 60
There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb7f8496488c8edd2886d9cdcc3b0d2
https://pubmed.ncbi.nlm.nih.gov/35390502
https://pubmed.ncbi.nlm.nih.gov/35390502
Autor:
Laura C. Greaves, Julia C. Whitehall
Publikováno v:
Biogerontology
Alterations in mitochondrial metabolism have been described as one of the major hallmarks of both ageing cells and cancer. Age is the biggest risk factor for the development of a significant number of cancer types and this therefore raises the questi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03919cbcbd0d9dea3283321678a98929
http://europepmc.org/articles/PMC7347693
http://europepmc.org/articles/PMC7347693
Autor:
Ben S. Barksby, Gabriele Spoletini, Marco Y W Zaki, Derek Manas, Jeremy French, Helen Brown, Abigail Watson, Lee A. Borthwick, Jack Leslie, Lee H. Reed, Mark C. Bryan, Julia C. Whitehall, Clive Griffiths, Michael Drinnan, Fiona Oakley, Marina García Macia, Stuart Robinson, Hannah L Paish, Laura C. Greaves, Steven A. White, Olivier Govaere, Xin Xu, Derek A. Mann, Jelena Mann
Publikováno v:
Hepatology (Baltimore, Md.)
Precision cut liver slices (PCLSs) retain the structure and cellular composition of the native liver and represent an improved system to study liver fibrosis compared to two-dimensional mono- or co-cultures. The aim of this study was to develop a bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e123604b076370e134297b63abcdce
https://doi.org/10.1002/hep.30651
https://doi.org/10.1002/hep.30651