Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Laura C. Andreae"'
Autor:
Eleftheria Pervolaraki, Adam L. Tyson, Francesca Pibiri, Steven L. Poulter, Amy C. Reichelt, R. John Rodgers, Steven J. Clapcote, Colin Lever, Laura C. Andreae, James Dachtler
Publikováno v:
Molecular Autism, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Background Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and recent genetic and mous
Externí odkaz:
https://doaj.org/article/8485e5c250a747b29746c07c166eb4ba
Publikováno v:
iScience, Vol 10, Iss , Pp 234-244 (2018)
Summary: Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically repo
Externí odkaz:
https://doaj.org/article/3d7da8a9a6db4aa096d02c02288e1654
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-9 (2018)
Abstract Background Deletions and mutations in the SHANK3 gene are strongly associated with autism spectrum disorder and underlie the autism-associated disorder Phelan–McDermid syndrome. SHANK3 is a scaffolding protein found at the post-synaptic me
Externí odkaz:
https://doaj.org/article/bc7203701d5b4f679027d2a1b382f843
Autor:
Laura C. Andreae, Juan Burrone
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 873-882 (2015)
Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but despite exceptionally high levels of spontaneous vesicle cycling occurring in developing axons, little is known of its function during this period
Externí odkaz:
https://doaj.org/article/d8f1d2b199474748a5793feaa259b0da
Autor:
Lorcan Browne, Liam Naybour, Laura C. Andreae, Emilie Rabesahala de Meritens, Robert Ellingford, Martyna J. Panasiuk, M. Albert Basson, Raghav Shaunak
Publikováno v:
Molecular Psychiatry
Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) and results in dysregulated expression of neurodevelopmental and synaptic genes during brain development. To reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8645773e241754c75ab3056ff731bc68
http://europepmc.org/articles/PMC8505247
http://europepmc.org/articles/PMC8505247
Autor:
Samuel E. Taylor, Lucia Dutan, Laura C. Andreae, Sagnik Bhattacharyya, Deepak Srivastava, Noel J. Buckley, Carole Shum, Jack Price, Ruth D. Taylor, Katherine Warre-Cornish, Emily Annuario
Publikováno v:
Shum, C, Dutan, L, Annuario, E, Warre-Cornish, K, Taylor, S E, Taylor, R D, Andreae, L C, Buckley, N J, Price, J, Bhattacharyya, S & Srivastava, D P 2020, ' Δ 9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons ', Molecular and Cellular Neuroscience, vol. 103, 103463 . https://doi.org/10.1016/j.mcn.2019.103463
Endocannabinoids regulate different aspects of neurodevelopment. In utero exposure to the exogenous psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC), has been linked with abnormal cortical development in animal models. However, much less i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4df105b5023a37b446741b8654cb892
https://doi.org/10.1016/j.mcn.2019.103463
https://doi.org/10.1016/j.mcn.2019.103463
Autor:
Dimitri Eigel, Julian Thiele, Petra B. Welzel, Andrea Brancale, Martyna J. Panasiuk, Carmine Varricchio, Romy Schuster, Laura C. Andreae, Katherine R. Long, Carsten Werner, Ben Newland, Max J. Männel, Wieland B. Huttner
Publikováno v:
Biomaterials. 271
The human brain has unique features that are difficult to study in animal models, including the mechanisms underlying neurodevelopmental and psychiatric disorders. Despite recent advances in human primary brain tissue culture systems, the use of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c898074b054cce0e67e751b263d7f4b
https://pubmed.ncbi.nlm.nih.gov/33618220
https://pubmed.ncbi.nlm.nih.gov/33618220
Autor:
Emilie Rabeshala de Meritens, Laura C. Andreae, Robert Ellingford, Raghav Shaunak, M. Albert Basson, Liam Naybour
Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) and results in dysregulated expression of neurodevelopmental and synaptic genes during brain development. To reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af3529e1abf4a29e00e4d14e0e0df1ab
https://doi.org/10.1101/2020.05.14.093187
https://doi.org/10.1101/2020.05.14.093187
Autor:
Laura C. Andreae, Stefan Aigner, Nick J. F. Gatford, Deepak Srivastava, Annie Kathuria, Jack Price, Ravi Jagasia, Paulina Nowosiad, Ruth D. Taylor, Walter Lucchesi
Publikováno v:
Molecular Psychiatry
Kathuria, A, Nowosiad, P, Jagasia, R, Aigner, S, Roberts, R D T, Andreae, L C, Gatford, N J F, Lucchesi, W, Srivastava, D P & Price, J 2018, ' Stem Cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development ', Molecular Psychiatry, vol. 23, no. 3, pp. 735-746 . https://doi.org/10.1038/mp.2017.185
Kathuria, A, Nowosiad, P, Jagasia, R, Aigner, S, Roberts, R D T, Andreae, L C, Gatford, N J F, Lucchesi, W, Srivastava, D P & Price, J 2018, ' Stem Cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development ', Molecular Psychiatry, vol. 23, no. 3, pp. 735-746 . https://doi.org/10.1038/mp.2017.185
Shank3 is a structural protein found predominantly at the post-synaptic density. Mutations in the SHANK3 gene have been associated with risk for autism spectrum disorder (ASD). We generated induced pluripotent stem cells (iPSCs) from control individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bb7b79f3e1945f5a026929e93f30a5
http://europepmc.org/articles/PMC5822449
http://europepmc.org/articles/PMC5822449
Autor:
Laura C. Andreae
Publikováno v:
European Journal of Neuroscience. 48:1867-1869
The FENS-Kavli winter symposium was held in December, 2017 at the Institute of Science and Technology, Austria. This short report reviews the session on neurological disorders, which included presentations on recent research into chronic pain, demyel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd4230bc9a4ad903c06e8dd47a6bd2a8
https://doi.org/10.1111/ejn.14065
https://doi.org/10.1111/ejn.14065