Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Laura C Greaves"'
Autor:
Xuefei Yu, Catherine Arden, Rolando Berlinguer-Palmini, Chun Chen, Carla Bradshaw, Anna LM Smith, Julia Whitehall, Michael White, Scott Anderson, Nicole Kattner, James Shaw, Doug Turnbull, Laura C Greaves, Mark Walker
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101489- (2022)
Objective: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondria
Externí odkaz:
https://doaj.org/article/7ed661841b25429ebf527135df0d42bd
Autor:
Laura C Greaves, Marco Nooteboom, Joanna L Elson, Helen A L Tuppen, Geoffrey A Taylor, Daniel M Commane, Ramesh P Arasaradnam, Konstantin Khrapko, Robert W Taylor, Thomas B L Kirkwood, John C Mathers, Douglass M Turnbull
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004620 (2014)
Age-related decline in the integrity of mitochondria is an important contributor to the human ageing process. In a number of ageing stem cell populations, this decline in mitochondrial function is due to clonal expansion of individual mitochondrial D
Externí odkaz:
https://doaj.org/article/bc764e33a1204f2fbee613cf25efce7f
Autor:
Laura C Greaves, Joanna L Elson, Marco Nooteboom, John P Grady, Geoffrey A Taylor, Robert W Taylor, John C Mathers, Thomas B L Kirkwood, Doug M Turnbull
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003082 (2012)
Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA) mutations have been documented in a number of ageing tissues and have been shown to be associated with cellul
Externí odkaz:
https://doaj.org/article/5a324ae0f5534499a8f83abc85c3b05a
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3276-3294 (2022)
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective g
Externí odkaz:
https://doaj.org/article/c6e193cc62b14a09a7f03a51ece490a6
Autor:
Ashwin Sachdeva, Claire A. Hart, Christopher D. Carey, Amy E. Vincent, Laura C. Greaves, Rakesh Heer, Pedro Oliveira, Michael D. Brown, Noel W. Clarke, Doug M. Turnbull
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Advances in multiplex immunofluorescence (mIF) and digital image analysis has enabled simultaneous assessment of protein defects in electron transport chain components. However, current manual methodology is time consuming and labour intensi
Externí odkaz:
https://doaj.org/article/e3358b5729ea406d9a319d06fa673144
Publikováno v:
Molecular Oncology. 16:3276-3294
Advancing age is a major risk factor for malignant transformation and the development of cancer. As such, over 50% of neoplasms occur in individuals over the age of 70. The pathologies of both ageing and cancer have been characterized by respective g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa8f5079c504a580d79e8b89138bd20
https://doi.org/10.1002/1878-0261.13291
https://doi.org/10.1002/1878-0261.13291
Autor:
Tianhong Su, Tiago M Bernardino Gomes, Anna L M Smith, Julia C Whitehall, Alasdair P Blain, Marie-Lune Simard, Louisa Scholten, James B Stewart, Doug M Turnbull, Conor Lawless, Laura C Greaves
Mitochondrial DNA (mtDNA) mutations accumulate in both mitotic and post-mitotic somatic tissues of normal individuals with age. They clonally expand within individual cells and cause mitochondrial dysfunction. In contrast, in patients with inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fb6633bc84b8031c2a5207f2b1455c0
https://doi.org/10.1101/2023.04.06.535821
https://doi.org/10.1101/2023.04.06.535821
Publikováno v:
Biochemistry and Cell Biology of Ageing: Part III Biomedical Science ISBN: 9783031214097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0184c5d3e02d64a12ccd8a1ec8f6a7d4
https://doi.org/10.1007/978-3-031-21410-3_4
https://doi.org/10.1007/978-3-031-21410-3_4
Autor:
Laura C. Greaves, Julia C. Whitehall
Publikováno v:
Biogerontology
Alterations in mitochondrial metabolism have been described as one of the major hallmarks of both ageing cells and cancer. Age is the biggest risk factor for the development of a significant number of cancer types and this therefore raises the questi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03919cbcbd0d9dea3283321678a98929
http://europepmc.org/articles/PMC7347693
http://europepmc.org/articles/PMC7347693
Autor:
Ben S. Barksby, Gabriele Spoletini, Marco Y W Zaki, Derek Manas, Jeremy French, Helen Brown, Abigail Watson, Lee A. Borthwick, Jack Leslie, Lee H. Reed, Mark C. Bryan, Julia C. Whitehall, Clive Griffiths, Michael Drinnan, Fiona Oakley, Marina García Macia, Stuart Robinson, Hannah L Paish, Laura C. Greaves, Steven A. White, Olivier Govaere, Xin Xu, Derek A. Mann, Jelena Mann
Publikováno v:
Hepatology (Baltimore, Md.)
Precision cut liver slices (PCLSs) retain the structure and cellular composition of the native liver and represent an improved system to study liver fibrosis compared to two-dimensional mono- or co-cultures. The aim of this study was to develop a bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e123604b076370e134297b63abcdce
https://doi.org/10.1002/hep.30651
https://doi.org/10.1002/hep.30651