Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura C Graham"'
Autor:
Penelope J Boyd, Wen-Yo Tu, Hannah K Shorrock, Ewout J N Groen, Roderick N Carter, Rachael A Powis, Sophie R Thomson, Derek Thomson, Laura C Graham, Anna A L Motyl, Thomas M Wishart, J Robin Highley, Nicholas M Morton, Thomas Becker, Catherina G Becker, Paul R Heath, Thomas H Gillingwater
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006744 (2017)
Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor neuron (SMN) protein. One remarkable, yet unresolved, feature of SMA
Externí odkaz:
https://doaj.org/article/6a1994812232441a91ce50a3acc16685
Autor:
Laura C. Graham, Rachel A. Kline, Douglas J. Lamont, Thomas H. Gillingwater, Neil A. Mabbott, Paul A. Skehel, Thomas M. Wishart
Publikováno v:
Cells, Vol 10, Iss 12, p 3403 (2021)
Synapses are particularly susceptible to the effects of advancing age, and mitochondria have long been implicated as organelles contributing to this compartmental vulnerability. Despite this, the mitochondrial molecular cascades promoting age-depende
Externí odkaz:
https://doaj.org/article/4016d2637beb42f992bd8d2a5e864fad
Autor:
null Leire M. Ledahawsky, null Maria Eirini Terzenidou, null Ruairidh Edwards, null Rachel A. Kline, null Laura C. Graham, null Samantha L. Eaton, null Dinja van der Hoorn, null Helena Chaytow, null Yu‐Ting Huang, null Ewout J.N. Groen, null Anna A. L. Motyl, null Douglas J. Lamont, null Kostas Tokatlidis, null Thomas M. Wishart, null Thomas H. Gillingwater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03143649c9c435da9090c5a119d02f6c
https://doi.org/10.1111/febs.16377/v2/response1
https://doi.org/10.1111/febs.16377/v2/response1
Autor:
Leire M. Ledahawsky, Maria Eirini Terzenidou, Ruairidh Edwards, Rachel A. Kline, Laura C. Graham, Samantha L. Eaton, Dinja van der Hoorn, Helena Chaytow, Yu‐Ting Huang, Ewout J. N. Groen, Anna A. L. Motyl, Douglas J. Lamont, Kostas Tokatlidis, Thomas M. Wishart, Thomas H. Gillingwater
Publikováno v:
The FEBS journal. 289(13)
Synapses are a primary pathological target in neurodegenerative diseases. Identifying therapeutic targets at the synapse could delay progression of numerous conditions. The mitochondrial protein SFXN3 is a neuronally enriched protein expressed in syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fe7f223cfbdb8a1aeaca41cbf7ba44
https://pubmed.ncbi.nlm.nih.gov/35092170
https://pubmed.ncbi.nlm.nih.gov/35092170
Autor:
Thomas H. Gillingwater, Paul Skehel, Thomas M. Wishart, Neil A. Mabbott, Laura C. Graham, Rachel A. Kline, Douglas J. Lamont
Publikováno v:
Cells
Graham, L C, Kline, R A, Lamont, D J, Gillingwater, T H, Mabbott, N A, Skehel, P A & Wishart, T M 2021, ' Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability ', Cells, vol. 10, no. 12 . https://doi.org/10.3390/cells10123403
Cells; Volume 10; Issue 12; Pages: 3403
Cells, Vol 10, Iss 3403, p 3403 (2021)
Graham, L C, Kline, R A, Lamont, D J, Gillingwater, T H, Mabbott, N A, Skehel, P A & Wishart, T M 2021, ' Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability ', Cells, vol. 10, no. 12 . https://doi.org/10.3390/cells10123403
Cells; Volume 10; Issue 12; Pages: 3403
Cells, Vol 10, Iss 3403, p 3403 (2021)
Synapses are particularly susceptible to the effects of advancing age, and mitochondria have long been implicated as organelles contributing to this compartmental vulnerability. Despite this, the mitochondrial molecular cascades promoting age-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aee667ea0c00cc8752fed1ef7145ba
https://doi.org/10.3390/cells10123403
https://doi.org/10.3390/cells10123403
Autor:
Laura C. Graham, Samantha L. Eaton, Paula J. Brunton, Abdelmadjid Atrih, Colin Smith, Douglas J. Lamont, Thomas H. Gillingwater, Giuseppa Pennetta, Paul Skehel, Thomas M. Wishart
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-16 (2017)
Background Neurons are highly polarized cells consisting of three distinct functional domains: the cell body (and associated dendrites), the axon and the synapse. Previously, it was believed that the clinical phenotypes of neurodegenerative diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::4539af002f0f896bd529f1ee4b37e816
http://link.springer.com/article/10.1186/s13024-017-0221-9
http://link.springer.com/article/10.1186/s13024-017-0221-9
Publikováno v:
Fuller, H R, Graham, L, Llavero Hurtado, M & Wishart, T 2016, ' Understanding the molecular consequences of inherited muscular dystrophies : advancements through proteomic experimentation ', Expert review of proteomics, vol. 13, no. 7, pp. 659-671 . https://doi.org/10.1080/14789450.2016.1202768
Introduction: Proteomic techniques offer insights into the molecular perturbations occurring in muscular-dystrophies (MD). Revisiting published datasets can highlight conserved downstream molecular alterations, which may be worth re-assessing to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc6b1e8723d48fc9d89f379a9fec2ed
https://doi.org/10.1080/14789450.2016.1202768
https://doi.org/10.1080/14789450.2016.1202768
Autor:
Ross A, Jones, Carl, Harrison, Samantha L, Eaton, Maica, Llavero Hurtado, Laura C, Graham, Leena, Alkhammash, Oladayo A, Oladiran, Andy, Gale, Douglas J, Lamont, Hamish, Simpson, Martin W, Simmen, Christian, Soeller, Thomas M, Wishart, Thomas H, Gillingwater
Publikováno v:
Cell Reports
Summary The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neuron to skeletal muscle to generate movement. It is also an experimentally accessible model synapse routinely studied in animal models to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::896fbbafa7dfc9c0634df9e6cbfcc26c
https://pubmed.ncbi.nlm.nih.gov/29186674
https://pubmed.ncbi.nlm.nih.gov/29186674
Autor:
Gillian Hunter, Amy Tavendale, Thomas H. Gillingwater, Douglas J. Lamont, Laura C. Graham, Thomas M. Wishart, Maica Llavero Hurtado, Arwin Aghamaleky Sarvestany
Publikováno v:
Journal of Proteome Research. 13:4546-4557
Low levels of survival of motor neuron (SMN) protein cause the neuromuscular disease spinal muscular atrophy (SMA), characterized by degeneration of lower motor neurons and atrophy of skeletal muscle. Recent work demonstrated that low levels of SMN a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415eeee1e4638f10530462cc09ac5e2
https://doi.org/10.1021/pr500492j
https://doi.org/10.1021/pr500492j
Autor:
Douglas J. Lamont, Thomas H. Gillingwater, Michael J. Naldrett, Thomas M. Wishart, Henryk F. Urbanski, Colin Smith, Steven G. Kohama, Laura C. Graham, Paul Skehel, Barry W. McColl
Publikováno v:
Graham, L C, Naldrett, M J, Kohama, S G, Smith, C, Lamont, D J, Mccoll, B W, Gillingwater, T H, Skehel, P, Urbanski, H F & Wishart, T M 2019, ' Regional molecular mapping of primate synapses during normal healthy ageing ', Cell Reports, vol. 27, no. 4, pp. 1018-1026.e4 . https://doi.org/10.1016/j.celrep.2019.03.096
Normal mammalian brain ageing is characterised by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6787f1e8efb5e261fc5a2a0c855c56c6
https://doi.org/10.1016/j.celrep.2019.03.096
https://doi.org/10.1016/j.celrep.2019.03.096