Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Laura Bover"'
Autor:
Junping Jing, Laura Bover, C Ian Mockridge, Kerry L Cox, Mark S Cragg, Tatyana Inzhelevskaya, Chris A Penfold, Vikki English, Jane E Willoughby, Hong Shi, Peter J Morley, Heather Jackson, Roopa Srinivasan, Tom Murray, Axel Hoos, Paul Bojczuk, James Smothers, Niranjan Yanamandra, Lang Dou, Sabyasachi Bhattacharya, Laura Seestaller-Wehr, David Kilian, Kui S Voo, Mel John, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Sara J Brett, Christopher Hopson, Elaine Paul, Stephen L Martin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-
Externí odkaz:
https://doaj.org/article/1d4a1e220c0f453894379600a08cb4a4
Autor:
Michael Green, Jingwei Liu, Zheng Zhang, Fuliang Chu, Sattva S Neelapu, Laura Bover, Ryan Sun, Jingjing Cao, Haopeng Yang, Timothy J Davis, Shao-qing Kuang, Xiaoyun Cheng, Swathi Karri, Long T Vien, Francisco Vega, Richard Eric Davis
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)
Background Chimeric antigen receptor (CAR) T cells targeting CD19 mediate potent and durable effects in B-cell malignancies. However, antigen loss or downregulation is a frequent cause of resistance. Here, we report development of a novel CAR T-cell
Externí odkaz:
https://doaj.org/article/d33413c6c13241c5b627404f177fbf5d
Autor:
Shubhra Singh, Jason Roszik, Neeraj Saini, Vipul Kumar Singh, Karishma Bavisi, Zhiqiang Wang, Long T. Vien, Zixi Yang, Suprateek Kundu, Richard E. Davis, Laura Bover, Adi Diab, Sattva S. Neelapu, Willem W. Overwijk, Kunal Rai, Manisha Singh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapies such as checkpoint blockade therapies are known to enhance anti-melanoma CD8+ T cell immunity, but only a fraction of patients treated with these therapies achieve durable immune response and disease control. It may be that CD8+ T cel
Externí odkaz:
https://doaj.org/article/c4a1d9b422e74dfd8114fa090bb46578
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1323 (2022)
Coenzyme A (CoA) is an essential co-factor at the intersection of diverse metabolic pathways. Cellular CoA biosynthesis is regulated at the first committed step—phosphorylation of pantothenic acid—catalyzed by pantothenate kinases (PANK1,2,3 in h
Externí odkaz:
https://doaj.org/article/3e2eb3fd9d214203bac1035e38f11586
Autor:
Wei Cao, Li Zhang, David B Rosen, Laura Bover, Gokuran Watanabe, Musheng Bao, Lewis L Lanier, Yong-Jun Liu
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e248 (2007)
Dendritic cells are equipped with lectin receptors to sense the extracellular environment and modulate cellular responses. Human plasmacytoid dendritic cells (pDCs) uniquely express blood dendritic cell antigen 2 (BDCA2) protein, a C-type lectin lack
Externí odkaz:
https://doaj.org/article/3f77714ebd5d4b3aa90e611d390b10b8
Autor:
Ye Li, Rafet Basar, Guohui Wang, Enli Liu, Judy S. Moyes, Li Li, Lucila N. Kerbauy, Nadima Uprety, Mohsen Fathi, Ali Rezvan, Pinaki P. Banerjee, Luis Muniz-Feliciano, Tamara J. Laskowski, Emily Ensley, May Daher, Mayra Shanley, Mayela Mendt, Sunil Acharya, Bin Liu, Alexander Biederstädt, Hind Rafei, Xingliang Guo, Luciana Melo Garcia, Paul Lin, Sonny Ang, David Marin, Ken Chen, Laura Bover, Richard E. Champlin, Navin Varadarajan, Elizabeth J. Shpall, Katayoun Rezvani
Publikováno v:
Nat Med
Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted
Autor:
Vijaya Ramachandran, Craig D. Logsdon, Huamin Wang, Laura Bover, Defeng Deng, Thiruvengadam Arumugam
Anterior gradient 2 (AGR2) promotes cancer growth, metastasis, and resistance to therapy via unknown mechanisms. We investigated the effects of extracellular AGR2 signaling through the orphan glycosylphosphatidylinositol-linked receptor C4.4A in panc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e170429edad73d7c6b6c5621ec2ef895
https://doi.org/10.1158/1535-7163.c.6536674.v1
https://doi.org/10.1158/1535-7163.c.6536674.v1
Autor:
Vijaya Ramachandran, Craig D. Logsdon, Huamin Wang, Laura Bover, Defeng Deng, Thiruvengadam Arumugam
Extracellular rAGR2-mediated functions, Candidate receptors binding and silencing, Silencing C4.4A reduced basal and rAGR2-mediated functions, Effects of AGR2 are mediated by C4.4A interacting with integrin beta 1, Monoclonal antibodies developed bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62474531af44535099a06972b4ae2be7
https://doi.org/10.1158/1535-7163.22501099.v1
https://doi.org/10.1158/1535-7163.22501099.v1
Autor:
Juan Fueyo, Mohammad B. Hossain, Carlo Toniatti, Frederick F. Lang, Ying Yuan, Luis M. Vence, Laura Bover, Karen Clise-Dwyer, Candelaria Gomez-Manzano, Yisel Rivera-Molina, Hong Jiang
Delta-24-RGDOX-induced necrosis (necr.) in the gliomas from C57BL/6 mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341fb4041a012df2d921a32374eb6e93
https://doi.org/10.1158/0008-5472.22414556
https://doi.org/10.1158/0008-5472.22414556
Autor:
Larry W. Kwak, Sattva S. Neelapu, Laura Bover, Soungchul Cha, Kunhwa Kim, Han Sun, Feng Wen, D. Lynne Smith, Wesley A. Cheng, Zhenyuan Dong, Ippei Sakamaki, Guowei Wei, Hong Qin
Purpose: mAbs such as anti-CD20 rituximab are proven therapies in B-cell malignancies, yet many patients develop resistance. Novel therapies against alternative targets are needed to circumvent resistance mechanisms. We sought to generate mAbs agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf6c9c74fab7462fffcaec50a860613
https://doi.org/10.1158/1078-0432.c.6526002
https://doi.org/10.1158/1078-0432.c.6526002