Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laura Bertoletti"'
Autor:
Elena Domínguez-Vega, Julie Schappler, Laura Bertoletti, Raffaella Colombo, Serge Rudaz, Ersilia De Lorenzi, Sara Raimondi, Govert W. Somsen, Rob Haselberg
Publikováno v:
Bertoletti, L, Schappler, J, Colombo, R, Rudaz, S, Haselberg, R, Dominguez Vega, E, Raimondi, S, Somsen, G W & De Lorenzi, E 2016, ' Evaluation of capillary electrophoresis-mass spectrometry for the analysis of the conformational heterogeneity of intact proteins using beta2-microglobulin as model compound. ', Analytica Chimica Acta, vol. 945, pp. 102-109 . https://doi.org/10.1016/j.aca.2016.10.010
Analytica Chimica Acta, 945, 102-109. Elsevier
Analytica Chimica Acta, 945, 102-109. Elsevier
In this work we explored the feasibility of different CE-ESI-MS set-ups for the analysis of conformational states of an intact protein. By using the same background electrolyte at quasi physiological conditions (50 mM ammonium bicarbonate, pH 7.4) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5501a172a841ac413d050aaffd69e19
https://doi.org/10.1016/j.aca.2016.10.010
https://doi.org/10.1016/j.aca.2016.10.010
Autor:
Sabine Inghelbrecht, Govert W. Somsen, Albertina Arien, Phennapha Saokham, Alexey Ryzhakov, Kristof Kimpe, Thorsteinn Loftsson, Laura Bertoletti, Koen Schrijnemakers, Thao Do Thi, Sergey V. Kurkov, Jef Stappaerts, Patrick Augustijns, Guy Van den Mooter, M. Ilias Jimidar, André Rodrigues Sá Couto
Publikováno v:
Journal of Pharmaceutical Sciences, 105(9), 2556-2569. John Wiley and Sons Inc.
Ryzhakov, A, DoThi, T, Stappaerts, J, Bertoletti, L, Kimpe, K, Rodrigues Sa Couto, A, Saokham, P, van den Mooter, G, Augustijns, P, Somsen, G W, Kurkov, S, Inghelbrecht 4, S, Arien, A, Jimidar, M I, Schrijnemakers, K & Loftsson, T 2016, ' Self-assembly of cyclodextrins and their complexes in aqueous solutions. ', Journal of Pharmaceutical Sciences, vol. 105, no. 9, pp. 2556-2569 . https://doi.org/10.1016/j.xphs.2016.01.019
Ryzhakov, A, DoThi, T, Stappaerts, J, Bertoletti, L, Kimpe, K, Rodrigues Sa Couto, A, Saokham, P, van den Mooter, G, Augustijns, P, Somsen, G W, Kurkov, S, Inghelbrecht 4, S, Arien, A, Jimidar, M I, Schrijnemakers, K & Loftsson, T 2016, ' Self-assembly of cyclodextrins and their complexes in aqueous solutions. ', Journal of Pharmaceutical Sciences, vol. 105, no. 9, pp. 2556-2569 . https://doi.org/10.1016/j.xphs.2016.01.019
Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are often used in toxicologic and phase I assessments of new drug candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d44a134e32be35670d7d87b458ef18
https://research.vu.nl/en/publications/708efab5-e270-4d31-82b4-cae30ba03a93
https://research.vu.nl/en/publications/708efab5-e270-4d31-82b4-cae30ba03a93
Autor:
Alessandra Altomare, Giulio Vistoli, Raffaella Colombo, Giancarlo Aldini, Luca Regazzoni, Ersilia De Lorenzi, Laura Bertoletti, Marina Carini, Loredana Marchese, Mara Colzani
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 91:193-201
By using a high resolution top-down and bottom-up approach we identified and characterized the AGEs of beta 2 -microglobulin (β 2 -m) formed by incubating the protein in the presence of glucose and of the main reactive carbonyl species. Glucose indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961a45ab91ca7672a01ce95b0a91caa0
https://doi.org/10.1016/j.jpba.2013.12.021
https://doi.org/10.1016/j.jpba.2013.12.021
Autor:
Laura Bertoletti, Gabriele Caccialanza, Luca Regazzoni, Giancarlo Aldini, Raffaella Colombo, Ersilia De Lorenzi, Franco Abballe
Publikováno v:
Analytica Chimica Acta. 771:108-114
In this work we present for the first time the use of ion-exchange liquid chromatography to separate the native form and a partially structured intermediate of the folding of the amyloidogenic protein beta2-microglobulin. Using a strong anion-exchang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31dc4887265878c9c5919eac3210386
https://doi.org/10.1016/j.aca.2013.01.058
https://doi.org/10.1016/j.aca.2013.01.058
Autor:
Laura, Bertoletti, Julie, Schappler, Raffaella, Colombo, Serge, Rudaz, Rob, Haselberg, Elena, Domínguez-Vega, Sara, Raimondi, Govert W, Somsen, Ersilia, De Lorenzi
Publikováno v:
Analytica chimica acta. 945
In this work we explored the feasibility of different CE-ESI-MS set-ups for the analysis of conformational states of an intact protein. By using the same background electrolyte at quasi physiological conditions (50 mM ammonium bicarbonate, pH 7.4) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eaca951ecf59b364ca6cd5ce1b6f9f65
https://pubmed.ncbi.nlm.nih.gov/27968711
https://pubmed.ncbi.nlm.nih.gov/27968711
Autor:
Federica Bisceglia, Sofia Giorgetti, Ersilia De Lorenzi, Palma Mangione, Laura Bertoletti, Sara Raimondi, Raffaella Colombo
Publikováno v:
Electrophoresis. 36(19)
Free solution capillary electrophoresis with UV detection is here used to retrieve information on the conformational changes of wild-type β2 -microglobulin and a series of naturally and artificially created variants known to have different stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3844b58ec4bf13a991dae82adfad025e
https://pubmed.ncbi.nlm.nih.gov/26084573
https://pubmed.ncbi.nlm.nih.gov/26084573