Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura Bavagnoli"'
Publikováno v:
Genes, Vol 7, Iss 9, p 57 (2016)
DNA is constantly exposed to both endogenous and exogenous damages. More than 10,000 DNA modifications are induced every day in each cell’s genome. Maintenance of the integrity of the genome is accomplished by several DNA repair systems. The core e
Externí odkaz:
https://doaj.org/article/73780a69e64c44fab779556d5aeba3db
Autor:
Laura Bavagnoli, William G Dundon, Anna Garbelli, Bianca Zecchin, Adelaide Milani, Geetha Parakkal, Fausto Baldanti, Stefania Paolucci, Romain Volmer, Yizeng Tu, Chuanyue Wu, Ilaria Capua, Giovanni Maga
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27789 (2011)
The Non-structural 1 (NS1) protein of avian influenza (AI) viruses is important for pathogenicity. Here, we identify a previously unrecognized tandem PDZ-ligand (TPL) domain in the extreme carboxy terminus of NS1 proteins from a subset of globally ci
Externí odkaz:
https://doaj.org/article/5439658cc88d483fbf0e9bb6fc9f6b10
Autor:
Giulia Campanini, Silvia Bione, Antonella Lisa, Giovanni Maga, Laura Bavagnoli, Fausto Baldanti, Giorgia Ceccotti, Elena Percivalle, Maurizio Forte
Publikováno v:
Antiviral research. 171
The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being able to suppress innate immune response and host protein synthesis. In this study we identified the human micro RNA hsa-miR-1307-3p as a novel potent suppr
Autor:
Ralph Imhof, Laura Bavagnoli, Elisa Mentegari, Emmanuele Crespan, Federica Bertoletti, Barbara van Loon, Ulrich Hübscher, Simone Sabbioneda, Giovanni Maga, Miroslava Kissova, Arman Nilforoushan, Shana J. Sturla
Publikováno v:
Nucleic Acids Research, 45 (5)
Nucleic Acids Research
Nucleic Acids Research
Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) oppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448e7adbccb842b8507692de02f781aa
https://hdl.handle.net/20.500.11850/191432
https://hdl.handle.net/20.500.11850/191432
Autor:
Laura Bavagnoli, Giovanni Maga
Publikováno v:
Future Virology. 8:195-208
As obligatory intracellular parasites, viruses need to take control of the metabolic pathways of the infected cells in order to complete their replication. Such an extraordinary ability must rely on specific, essential protein–protein interactions
Publikováno v:
Genes
Genes, Vol 7, Iss 9, p 57 (2016)
Genes, Vol 7, Iss 9, p 57 (2016)
DNA is constantly exposed to both endogenous and exogenous damages. More than 10,000 DNA modifications are induced every day in each cell’s genome. Maintenance of the integrity of the genome is accomplished by several DNA repair systems. The core e
Autor:
Stefano Cucuzza, Giovanni Maga, Stefania Paolucci, Francesca Rovida, Fausto Baldanti, Laura Bavagnoli, Giulia Campanini
Publikováno v:
Nucleic Acids Research
The PA protein of Influenza A virus (IAV) encoded by segment 3 acts as a specialized RNA endonuclease in the transcription of the viral genome. The same genomic segment encodes for a second shorter protein, termed PA-X, with the first 191 N-terminal
Publikováno v:
The FASEB Journal. 29
The PA subunit of the RNA dependent RNA polymerase of influenza virus is an endonuclease required for the cap-snatching mechanism leading to the synthesis of viral mRNA. Recently, the PA-X protein has been discovered in human influenza, which is tran
Autor:
Laura Bavagnoli, Giovanni Maga
Publikováno v:
Current medicinal chemistry. 18(35)
The influenza A virus is the main circulating influenza virus in the human population. It can cause disease also in birds and other mammals and is responsible for annual epidemics and occasional pandemics. The most known and deadly pandemic was the "
Publikováno v:
Current pharmaceutical biotechnology. 14(5)
Drug development is a long and expensive process. It starts from the identification of a small molecule (hit compound) endowed with the ability to suppress a cellular or viral enzyme essential for the development of a given disease and proceeds throu