Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Laura Barrow"'
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Akademický článek
Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation
Autor: Michael DeMicco, Laura Barrow, Bernadette Hickey, Kunwar Shailubhai, Patrick Griffin
Publikováno v: Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Background: Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase
Externí odkaz: https://doaj.org/article/13d128ce35eb4e6f9b8dcd50d1742408
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2
A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation
Autor: Kunwar Shailubhai, Blas Prieto, Marianela De La Portilla, Philip B. Miner, Gregory J Wiener, William Koltun, Patrick Griffin, Laura Barrow, Mary Beth Layton, Leslie Magnus
Publikováno v: The American Journal of Gastroenterology
Objectives: This study assessed the efficacy and safety of plecanatide, a guanylate cyclase-C (GC-C) agonist and the first uroguanylin analog approved for the treatment of chronic idiopathic constipation (CIC). Methods: This phase III, multicenter, d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032edc3391e4beb74e947050c6f17d7f
https://doi.org/10.1038/ajg.2016.611
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3
Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation
Autor: Bernadette Hickey, Patrick Griffin, Laura Barrow, Kunwar Shailubhai, Michael DeMicco
Publikováno v: Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology, Vol 10 (2017)
Background: Plecanatide, with the exception of a single amino acid replacement, is identical to human uroguanylin and is approved in the United States for adults with chronic idiopathic constipation (CIC). This double-blind, placebo-controlled, phase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7144e4968958958951d455b2dc5b00
https://pubmed.ncbi.nlm.nih.gov/29147135
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4
Plecanatide, an Oral Guanylate Cyclase C Agonist Acting Locally in the Gastrointestinal Tract, Is Safe and Well-Tolerated in Single Doses
Autor: Rong Feng, John A. Foss, Stephen Comiskey, Kunwar Shailubhai, Gail M. Comer, Gary S. Jacob, Laura Barrow
Publikováno v: Digestive Diseases and Sciences. 58:2580-2586
Plecanatide, an analogue of uroguanylin, activates the guanylate cyclase C (GC-C) receptor found on the GI mucosal epithelial cells, leading to secretion of fluid, facilitating bowel movements. Plecanatide is being investigated as a potential treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce6afccf669443d9b2d9be36f766c85
https://doi.org/10.1007/s10620-013-2684-z
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