PKCα Modulates Epithelial-to-Mesenchymal Transition and Invasiveness of Breast Cancer Cells Through ZEB1

Autor: María Candelaria Llorens, Fabiana Alejandra Rossi, Iris Alejandra García, Mariana Cooke, Martin C. Abba, Cynthia Lopez-Haber, Laura Barrio-Real, María Victoria Vaglienti, Mario Rossi, José Luis Bocco, Marcelo G. Kazanietz, Gastón Soria

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

ZEB1 is a master regulator of the Epithelial-to-Mesenchymal Transition (EMT) program. While extensive evidence confirmed the importance of ZEB1 as an EMT transcription factor that promotes tumor invasiveness and metastasis, little is known about its

Externí odkaz: https://doaj.org/article/ea4079824ca24cf1999973aeca05bf3b

Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells

Autor: Mariana Cooke, Victoria Casado-Medrano, Cynthia Lopez-Haber, Laura Barrio-Real, Marcelo G. Kazanietz, Anita Wang

Publikováno v: Oncogene

Diacylglycerol (DAG)/phorbol ester-regulated protein kinase C (PKC) isozymes have been widely linked to tumor promotion and the development of a metastatic phenotype. PKCε, an oncogenic member of the PKC family, is abnormally overexpressed in lung c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fcd149e8c12271cd206271f1de9363
https://doi.org/10.1038/s41388-019-0796-4

β3-Chimaerin, a novel member of the chimaerin Rac-GAP family

Autor: HongBin Wang, Marcelo G. Kazanietz, Laura Barrio-Real, Alvaro Gutierrez-Uzquiza, Federico Coluccio Leskow, Lautaro Zubeldia-Brenner

Publikováno v: Molecular Biology Reports. 41:2067-2076

Chimaerins are a family of diacylglycerol- and phorbol ester-regulated GTPase activating proteins (GAPs) for the small G-protein Rac. Extensive evidence indicates that these proteins play important roles in development, axon guidance, metabolism, cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01bf308653c978284f627417dcf51b9
https://doi.org/10.1007/s11033-014-3055-3

A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression

Autor: Oliver Rocks, María J. Caloca, Victoria Casado-Medrano, Ginesa Garcia-Rostan, Laura Barrio-Real, Matti Baumann

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Oncotarget

β2-chimaerin is a Rac1-specific negative regulator and a candidate tumor suppressor in breast cancer but its precise function in mammary tumorigenesis in vivo is unknown. Here, we study for the first time the role of β2-chimaerin in breast cancer u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515ca30d50f7f4efcb726c5499342aab
http://edoc.mdc-berlin.de/15653/1/15653oa.pdf

List of Contributors

Autor: Ricardo Abadie-Guedes, Anissa Abi-Dargham, Osama A. Abulseoud, Jelena Acevska, Ana Adan, María A. Aguilar, Maryam Akhgari, Robert Ali, Amelia J. Anderson-Mooney, Muhammad Anees, M. Carmen Arenas, Jamie Arndt, Daniele Ascheri, Nida Ashraf, Maxie Ashton, Olga Asimaki, Jean-Michel Aubry, Harinder Aujla, A. George Awad, Mahmoud A. Awara, Ana Bagues, Yatan P.S. Balhara, Francis Bambico, Laura Barrio-Real, Selena E. Bartlett, Balapal S. Basavarajappa, Aniruddha Basu, Claiton H.D. Bau, Matthew C. Beattie, Benjamin Becker, Anton L. Beer, Deepak Behera, Irina Benaiges, Dessa Bergen-Cico, Susan E. Bergeson, Wade H. Berrettini, Leandro J. Bertoglio, Charles S. Bockman, Stefan Borgwardt, Josiane Bourque, Muge Bozkurt, Katharine Alexandra Brennan, Hilary Briggs, Samanth J. Brooks, Rachel Picada Bulcão, Ute Burkhardt, Tracy R. Butler, Eduardo Rodrigues Cabrera, Daniela Caldirola, Russell C. Callaghan, Elza Callegari, María J. Caloca, Alline C. Campos, Carla Cannizzaro, Gavin Cape, Benjamin L. Carnell, Javier R. Caso, Lucas Henrique Cendron, Yun-Hsuan Chang, Gordon L.F. Cheng, Kao Chin Chen, Kanwaljit Chopra, Tony C.H. Chow, Rachael Cico, Jason B. Cook, Maurizio Coppola, Jose A. Cortes-Briones, Janna Cousijn, Richard C. Crist, Candice E. Crocker, Kirsty Danielson, Miguel Dasilva, Malay Dave, Mariella De Biasi, Cristiane R. de Carvalho, François De Guio, Dirk De Ridder, Sonia Dhiman, Giuseppina Diaferia, Marco Diana, Joseph R. DiFranza, Aneta Dimitrovska, Le-Anh Dinh-Williams, Maja Djurendic-Brenesel, Jonathan N. Dodd, Neil C. Dodge, Paul D. Drew, Rene Drucker Colín, Irena Dujmovic, Marcelo Dutra Arbo, Scott Edwards, Afshar Etemadi-Aleagha, Cuneyt Evren, Juan Fang, Camino Fernández-Rodríguez, Radmila Filipovic, Josef Finsterer, Megan L. Fitzgerald, Manoela V. Fogaça, Diego A. Forero, Hamdy Fouad Moselhy, Marco Antonio de Freitas, Cherrie Galletly, Borja García-Bueno, Jodi M. Gatley, David Germanaud, Roger S. Gifford, Paul Glue, Gabriella Gobbi, Carlos Goicoechea, Emilio González-Arnay, Emilio González-Reimers, Rogelio González-Sarmiento, Linda Gowing, Kenneth L. Grieve, Rubem Carlos Araújo Guedes, Consuelo Guerri, Francisco S. Guimarães, Leila Guller, Jennifer Harland, Seyyed A. Hashemi, Shiva Hashemizadeh, Bei He, Salvador Hernández-López, Tyson Hickle, Shirley Y. Hill, Joan Holgate, Wei Huang, Wei-Lieh Huang, Nicholas J. Hunt, René Hurlemann, Giuseppe Iannone, Fariha Idrees, Jawaria Idrees, Kazutaka Ikeda, Nato Ivanashvili, Iliyan Ivanov, Joseph L. Jacobson, Sandra W. Jacobson, Torbjörn U.C. Järbe, Y.L. Jiang, Farzaneh Jokar, Cynthia J.M. Kane, Megan Kangiser, Victor Karpyak, Jean A. King, Bronwyn M. Kivell, Eugene A. Kiyatkin, Jochen Klein, Michelle L. Klima, Sodikdjon A. Kodirov, Michal Korostynski, Mary Jeanne Kreek, Svetlana Kulevanova, Santosh Kumar, Berthold Langguth, Mirna Bainy Leal, Sheng-Yu Lee, Tatia M.C. Lee, John Leikaif, Shih-Hsien Lin, Yu-Hsuan Lin, Xiu Liu, Valentina Lorenzetti, Ru-Band Lu, Rita Machaalani, Antoniette Maldonado-Devincci, Jean-François Mangin, Dimitra Mangoura, Patrick Manning, Jahan P. Marcu, Simon McCabe, M. Adrienne McGinn, Diana L. McKinney, Ryan McLaughin, Ian McLaughlin, Ernesta Meintjes, Narasimha M. Midde, Stefan Mihailescu, José Miñarro, Raffaella Mondola, A. Leslie Morrow, Nina R. Mota, Jeffrey Newcorn, Daisuke Nishizawa, José N. Nobrega, Christina N. Nona, Nicolas Nuñez, Ingrid Nylander, Jessica W. O’Brien, Francesco Oliva, Sara Palm, Mauricio R. Papini, Byung Lae Park, María Pascual, Juan Pedraza, Giampaolo Perna, Rocco Luigi Picci, Marcin Piechota, Vladimir Pilija, Charles Pinto, Stéphane Potvin, Jagdeo Prasad Rawat, Victor R. Preedy, Brittany M. Priddy, Ryszard Przewlocki, Jimit G. Raghav, Rajkumar Rajendram, Roshanna Rajendram, P.S.S. Rao, Anirban Ray, Ameneh Rezayof, Casto Rivadulla, Marta Rodríguez-Arias, Luciana Grazziotin Rossato, Diego L. Rovaris, Christina L. Ruby, Nikos Sakellaridis, Saad Salman, Francisco Santolaria-Fernández, Siddharth Sarkar, Jason B. Schechter, André Schmidt, Susan Scholl, April Scott, Masroor Shariff, Shiwali Sharma, Hyoung Doo Shin, Thakur Gurjeet Singh, Namita Sinha, Patrick D. Skosnik, Ranilson de Souza Bezerra, Dustin J. Stairs, Gjoshe Stefkov, Dan J. Stein, Cristina A.J. Stern, Claudia Stöllberger, Reinaldo N. Takahashi, H.C. Tang, Josephine Tarren, Philip G. Tibbo, Vinod Tiwari, Carmen Torres, Federica Trivelli, Penelope Truman, Emmanouella Tsirimonaki, Sven Vanneste, Andrea R. Vansickel, Leandro F. Vendruscolo, Maria S.M. Wai, Marc Walter, Karen A. Waters, Jeffrey L. Weiner, Jodi J. Weinstein, Jordyn Weisberg, Annie M. Whitaker, Sarah Wolf-Stanton, Chen-Ying Wu, Sharon L. Wu, Cheryl C.H. Yang, Yen Kuang Yang, Kirti Yeshwant Tandel, D.T. Yew, Yashar Yousefzadeh Fard, Yan Zhou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcf12b9446119863402c7acf45328e6e
https://doi.org/10.1016/b978-0-12-800213-1.01002-6