Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Laura B. Uwituze"'
Autor:
Qing Li, Fan Wenjie, Laura B. Uwituze, Yan Li, Qineng Gong, Hong Ran, Jie Tian, Renxiao Wang, Mi Zhou, Zhichao Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:10260-10285
Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein inhibitors in tumors with Mcl-1 overexpression. Based on previously discovered compounds with a 3-phenylthiophene-2-sulfonamide core moiety, in
Autor:
Yan, Li, Wenjie, Fan, Qineng, Gong, Jie, Tian, Mi, Zhou, Qing, Li, Laura B, Uwituze, Zhichao, Zhang, Ran, Hong, Renxiao, Wang
Publikováno v:
Journal of medicinal chemistry. 64(14)
Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein inhibitors in tumors with Mcl-1 overexpression. Based on previously discovered compounds with a 3-phenylthiophene-2-sulfonamide core moiety, in
Autor:
Hong Zhang, Yafei Guo, Xiaodong Zhang, Zongwei Guo, Laura B. Uwituze, Zuguang Xue, Donghai Lin, Hang Wang, Ting Song, Fangkui Yin, Ziqian Wang, Zhichao Zhang, Hao Pan
Publikováno v:
Leukemia. 35(10)
Herein, we screened a novel inhibitor of the Hsp70-Bim protein-protein interaction (PPI), S1g-2, from a Bcl-2 inhibitor library; this compound specifically disrupted the Hsp70-Bim PPI by direct binding to an unknown site adjacent to that of an allost
Autor:
Ting Song, Sheng Zhou, Hao Pan, Hang Wang, Yafei Guo, Ziqian Wang, Jian Dai, Fangkui Yin, Xiaodong Zhang, Laura B. Uwituze, Hong Zhang, Zongwei Guo, Zhichao Zhang, Tong Ji
Publikováno v:
European journal of medicinal chemistry. 220
Targeting cancer-related Hsp70-Bim protein-protein interactions (PPIs) offers a new strategy for the design of Hsp70 inhibitors. Herein, we discovered a novel Hsp70 inhibitor, S1g-6, based on the established BH3 mimetics. S1g-6 exhibited sub-μM bind