Výsledky vyhledávání - "Laura B. Rosen"

The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial

Autor: Patricio O’Donnell, Cheng Dong, Venkatesha Murthy, Mahnaz Asgharnejad, Xiaoming Du, Ann Summerfelt, Hong Lu, Lin Xu, Jens R. Wendland, Eduardo Dunayevich, Derek L. Buhl, Robert Litman, William P. Hetrick, L. Elliot Hong, Laura B. Rosen

Publikováno v: Neuropsychopharmacology. 48:1052-1059

Several attempts have been made to enhance N-methyl-D-aspartate (NMDA) receptor function in schizophrenia, but they have yielded mixed results. Luvadaxistat, a D-amino acid oxidase (DAAO) inhibitor that increases the glutamate co-agonist D-serine lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c93f6ae00e1e9862d1fe73d00622eaf
https://doi.org/10.1038/s41386-023-01560-0

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Early-stage comparative effectiveness: Randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients

Autor: Christopher Lines, M. Gail Murphy, Chantal Mahon, John J. Renger, Hong Sun, John A. Wagner, Kate Mostoller, W. Joseph Herring, Catherine MacLeod, Gary G. Kay, Lingling Han, Valerie Schulz, Junshui Ma, Kevin R. Brown, Laura B. Rosen

Publikováno v: The Journal of Clinical Pharmacology. 53:1294-1302

Histaminergic neurons are regulators of the sleep-wake cycle. We evaluated the alerting effects of MK-7288 (10, 20 mg), a novel histamine-3 receptor inverse agonist (H3RIA), along with modafinil (200 mg), a standard treatment, in a randomized, double

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::691bde734118828ca575e167420b3290
https://doi.org/10.1002/jcph.182

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Clinical Bioavailability of the Novel BACE1 Inhibitor Lanabecestat (AZD3293): Assessment of Tablet Formulations Versus an Oral Solution and the Impact of Gastric pH on Pharmacokinetics

Autor: Scott A. Monk, Laura B. Rosen, Alan R. Kugler, Pankaj Daga, Jamie Mullen, Naidong Ye, David M. Bender, Margaret Minkwitz

Publikováno v: Clinical Pharmacology in Drug Development

The relative bioavailability of lanabecestat administered as 2 tablet formulations versus an oral solution was investigated. This phase 1 single‐center, open‐label, randomized, 3‐period crossover study involved healthy male and nonfertile femal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e9a20d3e5e5e2a65959e6e39eadd96
https://pubmed.ncbi.nlm.nih.gov/29319935

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AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease

Autor: Samantha Budd Haeberlein, Alan R. Kugler, Tina Olsson, Robert C. Alexander, Naidong Ye, Muir Russell, Justine Maltby, Laura B. Rosen, Susanna Eketjäll, Ronald Goldwater, Gvido Cebers, Larry Ereshefsky, David Han

Publikováno v: Journal of Alzheimer's disease : JAD. 55(3)

AZD3293 (LY3314814) is a promising new potentially disease-modifying BACE1 (β-secretase) inhibitor in Phase III clinical development for the treatment of Alzheimer's disease. Reported here are the first two Phase I studies: (1) a single ascending do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649776ea599109ee35a3b3a619d31886
https://pubmed.ncbi.nlm.nih.gov/27767991

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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Autor: Anthony L. Gotter, Vladimir Svetnik, Arie Struyk, Pamela L. Tannenbaum, Mark S. Forman, Nicole Calder, Susan L. Garson, John J. Renger, Christopher J. Winrow, Joanne Stevens, Anthony J. Roecker, Laura B. Rosen, W. Joseph Herring, Ka Lai Yee, Inge De Lepeleire, Xiaodong Li, Paul J. Coleman, Steven V. Fox, Charles M. Harrell

Publikováno v: Scientific Reports

Orexin neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant mediator of arousal promotion. The potential for single OX2R antagonism to effectively promote sleep has yet to be demonstrated in humans. MK-1064

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f3bc3db6a5889a09f8b0e6f1bbba05

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Equivalent Dynamic Human Brain NK1-Receptor Occupancy Following Single-Dose i.v. Fosaprepitant vs. Oral Aprepitant as Assessed by PET Imaging

Publikováno v: Clinical Pharmacology & Therapeutics. 92:243-250

The type 1 neurokinin receptor (NK1R) antagonist aprepitant and its i.v. prodrug fosaprepitant have been approved for prevention of acute and delayed nausea and vomiting associated with chemotherapy. This study evaluated the magnitude and duration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454387a449b7c57da686bdcb529ca993
https://doi.org/10.1038/clpt.2012.62

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The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol

Publikováno v: Journal of Psychopharmacology, 26, 2, pp. 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302

Item does not contain fulltext Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1fbad04db88a008450901c8347b622
https://hdl.handle.net/2066/109808

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Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients

Autor: Hong, Sun, Catherine, MacLeod, Kate, Mostoller, Chantal, Mahon, Lingling, Han, John J, Renger, Junshui, Ma, Kevin R, Brown, Valerie, Schulz, Gary G, Kay, W Joseph, Herring, Christopher, Lines, Laura B, Rosen, M Gail, Murphy, John A, Wagner

Publikováno v: Journal of clinical pharmacology. 53(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b75bcfcc9306522d45d2d1aa12589877
https://pubmed.ncbi.nlm.nih.gov/24122944

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Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men

Autor: Eric Mangin, Hong Sun, Junshui Ma, Gail Murphy, Ka Lai Yee, Xiaodong Li, Laura B. Rosen, Darren Wilbraham, Christopher Lines, Nicole Lewis, William P. Kennedy, Chodakewitz Jeffrey A, Nicole Calder, Susan Ermlich

Publikováno v: Sleep. 36(2)

Study objectives Suvorexant (MK-4305) is an orexin receptor antagonist being developed for the treatment of insomnia. This report describes the effects of nighttime administration of suvorexant on polysomnography (PSG) sleep parameters in healthy you

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f894414c518f63c0ba151aceca896fa
https://pubmed.ncbi.nlm.nih.gov/23372274

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Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels

Autor: Laura B. Rosen, Michael E. Greenberg

Publikováno v: Proceedings of the National Academy of Sciences. 93:1113-1118

To understand the mechanisms by which electrical activity may generate long-term responses in the nervous system, we examined how activation of voltage-sensitive calcium channels (VSCCs) can stimulate the Ras/mitogen-activated protein kinase (MAPK) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0a558ceb499a7e2dfb03d9fc33889e
https://doi.org/10.1073/pnas.93.3.1113

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