Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Laura B. L. Wittemans"'
Autor:
Samvida S. Venkatesh, Habib Ganjgahi, Duncan S. Palmer, Kayesha Coley, Gregorio V. Linchangco, Qin Hui, Peter Wilson, Yuk-Lam Ho, Kelly Cho, Kadri Arumäe, Million Veteran Program, Estonian Biobank Research Team, Laura B. L. Wittemans, Christoffer Nellåker, Uku Vainik, Yan V. Sun, Chris Holmes, Cecilia M. Lindgren, George Nicholson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Obesity is a heritable disease, characterised by excess adiposity that is measured by body mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known about the genetic contribution to adiposity trajectories over a
Externí odkaz:
https://doaj.org/article/03c536ba941147bc8728c18296e4cc33
Autor:
Katherine A. Kentistou, Jian’an Luan, Laura B. L. Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R. Speakman, Nicholas J. Wareham, Timothy J. Kendall, Claudia Langenberg, James F. Wilson, Peter K. Joshi, Nicholas M. Morton
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Our understanding of the genetic contribution to human adiposity is incomplete, as few studies measure adiposity directly. Here, the authors impute whole-body imaging adiposity phenotypes in large biobanks, enhancing their power to discover genes dri
Externí odkaz:
https://doaj.org/article/903568c5d1ae45e28b5b075edb1b116a
Autor:
Samvida S. Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M. Becker, Ingrid Granne, Krina T. Zondervan, Michael V. Holmes, Cecilia M. Lindgren, Laura B. L. Wittemans
Publikováno v:
PLoS Medicine, Vol 19, Iss 2 (2022)
Background Obesity is observationally associated with altered risk of many female reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal uterine bleeding, endometriosis, infertility, and pregnancy-related disorders. However
Externí odkaz:
https://doaj.org/article/e46ae05bdb3a49b89ade5c63eeeac256
Autor:
Laura B. L. Wittemans, Luca A. Lotta, Clare Oliver-Williams, Isobel D. Stewart, Praveen Surendran, Savita Karthikeyan, Felix R. Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L. Griffin, Nita G. Forouhi, Robert A. Scott, Angela M. Wood, Stephen Burgess, Joanna M. M. Howson, John Danesh, Nicholas J. Wareham, Adam S. Butterworth, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a cau
Externí odkaz:
https://doaj.org/article/b179b3632faa45f4b864e7498db649ab
Autor:
Samvida S Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M Becker, Ingrid Granne, Krina T Zondervan, Michael V Holmes, Cecilia M Lindgren, Laura B L Wittemans
Publikováno v:
PLoS Medicine, Vol 19, Iss 9, p e1004095 (2022)
[This corrects the article DOI: 10.1371/journal.pmed.1003679.].
Externí odkaz:
https://doaj.org/article/4b78f2ca494b4596a1ef8e3f3c6ab0aa
Autor:
Samvida S. Venkatesh, Habib Ganjgahi, Duncan S. Palmer, Kayesha Coley, Laura B. L. Wittemans, Christoffer Nellaker, Chris Holmes, Cecilia M. Lindgren, George Nicholson
Obesity is a heritable disease, characterised by excess adiposity that is measured by body mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known about the genetic contribution to adiposity trajectories over adulthood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5124820cc55cf0167fc149c11e0a2a36
https://doi.org/10.1101/2023.01.09.23284364
https://doi.org/10.1101/2023.01.09.23284364
Autor:
Kay-Tee Khaw, Angela M. Wood, Julian L. Griffin, Gabi Kastenmüller, Fiona M. Gribble, Adam S. Butterworth, Luca A. Lotta, Verena Zuber, Chen Li, Victoria P W Auyeung, Johannes Raffler, Isobel D. Stewart, Nita G. Forouhi, Jian'an Luan, Nicholas J. Wareham, Claudia Langenberg, Maik Pietzner, Laura B. L. Wittemans, Eleanor Wheeler, Robert A. Scott, Roberto Bonelli, John Danesh, Frank Reimann, Praveen Surendran, Stephen Burgess, Ellie Paige, Clare Oliver-Williams, Albert Koulman, Fumiaki Imamura, Eric B. Fauman, Gregory A. Michelotti, Melanie Bahlo, Eleanor Sanderson, Emma K. Biggs
Publikováno v:
Nat. Genet. 53, 54-64 (2021)
In cross-platform analyses of 174 metabolites, we identify 499 associations (P
Autor:
Mine Koprulu, Yajie Zhao, Eleanor Wheeler, Liang Dong, Nuno Rocha, Chen Li, John D Griffin, Satish Patel, Marcel Van de Streek, Craig A Glastonbury, Isobel D Stewart, Felix R Day, Jian’an Luan, Nicholas Bowker, Laura B L Wittemans, Nicola D Kerrison, Lina Cai, Debora M E Lucarelli, Inês Barroso, Mark I McCarthy, Robert A Scott, Vladimir Saudek, Kerrin S Small, Nicholas J Wareham, Robert K Semple, John R B Perry, Stephen O’Rahilly, Luca A Lotta, Claudia Langenberg, David B Savage
Publikováno v:
Koprulua, M, Zhaoa, Y, Wheeler, E, Liang, D, Rocha, N, Li, C, Griffin, J D, Patel, S, Van de Streek, M, Glastonbury, C A, Stewart, I, Day, F R, Luan, J, Bowker, N, Wittemans, L B L, Kerrison, N D, Cai, L, Lucarelli, D M E, Barroso, I, McCarthy, M I, Scott, R A, Saudek, V, Small, K S, Wareham, N J, Semple, R K, Perry, J R B, O’Rahilly, S, Lotta, L A, Langenberg, C & Savage, D B 2021, ' Identification of rare loss of function genetic variation regulating body fat distribution ', Journal of Clinical Endocrinology & Metabolism . https://doi.org/10.1210/clinem/dgab877
Context Biological and translational insights from large-scale, array-based genetic studies of fat distribution, a key determinant of metabolic health, have been limited by the difficulty in linking predominantly noncoding variants to specific gene t
Autor:
John R. B. Perry, Yajie Zhao, Nicholas Bowker, Craig A. Glastonbury, Isobel D. Stewart, Laura B. L. Wittemans, Felix R. Day, Mine Koprulu, Marcel Van de Streek, Stephen O'Rahilly, Claudia Langenberg, Nicola D. Kerrison, Mark I. McCarthy, Luca A. Lotta, Liang Dong, Jian'an Luan, Robert A. Scott, Nuno Rocha, Satish Patel, Nicholas J. Wareham, Vladimir Saudek, Debora Lucarelli, Eleanor Wheeler, Robert K. Semple, Inês Barroso, Kerrin S. Small, David B. Savage
Biological and translational insights from large-scale, array-based genetic studies of fat distribution, a key determinant of metabolic health, have been limited by the difficulty in linking identified predominantly non-coding variants to specific ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c889997b8bb89441f47e5ae202000c81
https://doi.org/10.1101/2021.09.11.21263427
https://doi.org/10.1101/2021.09.11.21263427
Autor:
Jia Zhu, Natàlia Pujol-Gualdo, Laura B L Wittemans, Cecilia M Lindgren, Triin Laisk, Joel N Hirschhorn, Yee-Ming Chan
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism
Context Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and hyperandrogenism and can be associated with cardiometabolic dysfunction, but it remains unclear which of these features are inciting causes and which are secondary