Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Laura B Creemers"'
Autor:
Frances C Bach, Lisanne T Laagland, Michael P Grant, Laura B Creemers, Keita Ito, Björn P Meij, Fackson Mwale, Marianna A Tryfonidou
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187831 (2017)
Degeneration of the intervertebral disc (IVD) is a frequent cause for back pain in humans and dogs. Link-N stabilizes proteoglycan aggregates in cartilaginous tissues and exerts growth factor-like effects. The human variant of Link-N facilitates IVD
Externí odkaz:
https://doaj.org/article/09edd18fe1d9499f9a140f5562c07881
Autor:
Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R. Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P. Meij, Jens Thies, Pieter Emans, Fetullah C. Öner, George Mihov, Joao Pedro Garcia, Anne S. Ulrich, Sibylle Grad, Marianna A. Tryfonidou, Hugo van Ingen, Laura B. Creemers
Publikováno v:
Drug Delivery, Vol 31, Iss 1 (2024)
Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enab
Externí odkaz:
https://doaj.org/article/e74ff26b3ae344bf99b69a5fc7b3d7c3
Autor:
Jos Malda, Janny C de Grauw, Kim E M Benders, Marja J L Kik, Chris H A van de Lest, Laura B Creemers, Wouter J A Dhert, P René van Weeren
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57683 (2013)
Mammalian articular cartilage serves diverse functions, including shock absorption, force transmission and enabling low-friction joint motion. These challenging requirements are met by the tissue's thickness combined with its highly specific extracel
Externí odkaz:
https://doaj.org/article/84880d6bcf394e20aa9ef130be31578a
Autor:
Katrin Agnes Muenzebrock, Fiona Y. W. Ho, Adriano P. Pontes, Carla Jorquera-Cordero, Lizette Utomo, Joao Pedro Garcia, Paul C. Willems, Tim J. M. Welting, Jaap Rip, Laura B. Creemers
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 438 (2024)
Chronic lower back pain caused by intervertebral disc degeneration and osteoarthritis (OA) are highly prevalent chronic diseases. Although pain management and surgery can alleviate symptoms, no disease-modifying treatments are available. mRNA deliver
Externí odkaz:
https://doaj.org/article/54e356b8756440688f3f72529fd672dd
Autor:
Adriano P. Pontes, Steffen van der Wal, Saketh R. Ranamalla, Karin Roelofs, Ioan Tomuta, Laura B. Creemers, Jaap Rip
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Disulfide-containing poly(amidoamine) (PAA) is a cationic and bioreducible polymer, with potential use as a nanocarrier for mRNA delivery in the treatment of several diseases including osteoarthritis (OA). Successful transfection of joint cells with
Externí odkaz:
https://doaj.org/article/9754f335ed1c4961b19731fe693f481d
Autor:
Jie Du, João P. Garcia, Frances C. Bach, Anna R. Tellegen, Sibylle Grad, Zhen Li, René M. Castelein, Björn P. Meij, Marianna A. Tryfonidou, Laura B. Creemers
Publikováno v:
Journal of Orthopaedic Translation, Vol 37, Iss , Pp 23-36 (2022)
Background: Intervertebral disc (IVD) degeneration is suggested as a major cause of chronic low back pain (LBP). Intradiscal delivery of growth factors has been proposed as a promising strategy for IVD repair and regeneration. Previously, BMP-4 was s
Externí odkaz:
https://doaj.org/article/850513532fae49d98f7ddb56266e7ac3
Autor:
Shaghayegh Basatvat, Frances C. Bach, Marcos N. Barcellona, Abbie L. Binch, Conor T. Buckley, Brian Bueno, Nadeen O. Chahine, Ana Chee, Laura B. Creemers, Stefan Dudli, Bailey Fearing, Stephen J. Ferguson, Jennifer Gansau, Benjamin Gantenbein, Rahul Gawri, Juliane D. Glaeser, Sibylle Grad, Julien Guerrero, Lisbet Haglund, Paula A. Hernandez, Judith A. Hoyland, Charles Huang, James C. Iatridis, Svenja Illien‐Junger, Liufang Jing, Petra Kraus, Lisanne T. Laagland, Gernot Lang, Victor Leung, Zhen Li, Thomas Lufkin, Josette C. vanMaanen, Emily E. McDonnell, Chris J. Panebianco, Steven M. Presciutti, Sanjna Rao, Stephen M. Richardson, Sarah Romereim, Tara C. Schmitz, Jordy Schol, Lori Setton, Dmitriy Sheyn, Joseph W. Snuggs, Y. Sun, Xiaohong Tan, Marianna A. Tryfonidou, Nam Vo, Dong Wang, Brandon Williams, Rebecca Williams, S. Tim Yoon, Christine L. Le Maitre
Publikováno v:
JOR Spine, Vol 6, Iss 1, Pp n/a-n/a (2023)
Abstract Background In vitro studies using nucleus pulposus (NP) cells are commonly used to investigate disc cell biology and pathogenesis, or to aid in the development of new therapies. However, lab‐to‐lab variability jeopardizes the much‐need
Externí odkaz:
https://doaj.org/article/4cf7143b0ac5450a9e437e4c96e1d1cf
Autor:
Lisanne T. Laagland, Frances C. Bach, Laura B. Creemers, Christine L. Le Maitre, Deepani W. Poramba‐Liyanage, Marianna A. Tryfonidou
Publikováno v:
JOR Spine, Vol 5, Iss 3, Pp n/a-n/a (2022)
Abstract Background Repopulating the degenerated intervertebral disc (IVD) with tissue‐specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell‐based therapy h
Externí odkaz:
https://doaj.org/article/74873276124d4d7da3574e58ef5e9da1
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2639 (2022)
Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial joint and globally impacts more than one in five individuals aged 40 and over, representing a huge socioeconomic burden. Drug penetration into and retention w
Externí odkaz:
https://doaj.org/article/61a42e15653d436695a9ec1c62088d65
Autor:
Luana Zerrillo, Maria Rosa Gigliobianco, Domenico D’Atri, Joao Pedro Garcia, Fabio Baldazzi, Yanto Ridwan, Gastón Fuentes, Alan Chan, Laura B. Creemers, Roberta Censi, Piera Di Martino, Luis J. Cruz
Publikováno v:
Nanomaterials, Vol 12, Iss 13, p 2248 (2022)
Nanoparticles (NPs) have a tremendous potential in medicinal applications, and recent studies have pushed the boundaries in nanotherapy, including in osteoarthritis treatments. The aim of this study was to develop new poly(lactide-co-glycolide) (PLGA
Externí odkaz:
https://doaj.org/article/21acac82fbd7423785630b551493c74e