Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Laura B, Uwituze"'
Autor:
Qing Li, Fan Wenjie, Laura B. Uwituze, Yan Li, Qineng Gong, Hong Ran, Jie Tian, Renxiao Wang, Mi Zhou, Zhichao Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:10260-10285
Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein inhibitors in tumors with Mcl-1 overexpression. Based on previously discovered compounds with a 3-phenylthiophene-2-sulfonamide core moiety, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9bb852e252a6786264bd69f5e7ea860
https://doi.org/10.1021/acs.jmedchem.1c00690
https://doi.org/10.1021/acs.jmedchem.1c00690
Autor:
Yan, Li, Wenjie, Fan, Qineng, Gong, Jie, Tian, Mi, Zhou, Qing, Li, Laura B, Uwituze, Zhichao, Zhang, Ran, Hong, Renxiao, Wang
Publikováno v:
Journal of medicinal chemistry. 64(14)
Selective Mcl-1 inhibitors may overcome the drug resistance caused by current anti-apoptotic Bcl-2 protein inhibitors in tumors with Mcl-1 overexpression. Based on previously discovered compounds with a 3-phenylthiophene-2-sulfonamide core moiety, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b362f14dfb31fd33340dc2818e861e3b
https://pubmed.ncbi.nlm.nih.gov/34228434
https://pubmed.ncbi.nlm.nih.gov/34228434
Autor:
Hong Zhang, Yafei Guo, Xiaodong Zhang, Zongwei Guo, Laura B. Uwituze, Zuguang Xue, Donghai Lin, Hang Wang, Ting Song, Fangkui Yin, Ziqian Wang, Zhichao Zhang, Hao Pan
Publikováno v:
Leukemia. 35(10)
Herein, we screened a novel inhibitor of the Hsp70-Bim protein-protein interaction (PPI), S1g-2, from a Bcl-2 inhibitor library; this compound specifically disrupted the Hsp70-Bim PPI by direct binding to an unknown site adjacent to that of an allost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f948dab84b413a23dda2eda59f9d71c
https://pubmed.ncbi.nlm.nih.gov/34007045
https://pubmed.ncbi.nlm.nih.gov/34007045
Autor:
Ting Song, Sheng Zhou, Hao Pan, Hang Wang, Yafei Guo, Ziqian Wang, Jian Dai, Fangkui Yin, Xiaodong Zhang, Laura B. Uwituze, Hong Zhang, Zongwei Guo, Zhichao Zhang, Tong Ji
Publikováno v:
European journal of medicinal chemistry. 220
Targeting cancer-related Hsp70-Bim protein-protein interactions (PPIs) offers a new strategy for the design of Hsp70 inhibitors. Herein, we discovered a novel Hsp70 inhibitor, S1g-6, based on the established BH3 mimetics. S1g-6 exhibited sub-μM bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4122745e901693cc59af99f3a0fda8c3
https://pubmed.ncbi.nlm.nih.gov/33906046
https://pubmed.ncbi.nlm.nih.gov/33906046