Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Laura Arrigoni"'
Autor:
Carlos Alfonso-Gonzalez, Laura Arrigoni, Hasan Can Ozbulut, Stefanie Falk, Ulrike Bönisch, Valérie Hilgers
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102505- (2023)
Summary: We present a detailed protocol for sequencing full-length mRNA isoforms using the Oxford nanopore long-read sequencing technology. We describe steps for poly(A) RNA isolation, library preparation, and cDNA size selection. We then detail proc
Externí odkaz:
https://doaj.org/article/27c78bb24a214c3a8043c88da0b03092
Autor:
Francesco Ferrari, Laura Arrigoni, Henriette Franz, Annalisa Izzo, Ludmila Butenko, Eirini Trompouki, Tanja Vogel, Thomas Manke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Neuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by
Externí odkaz:
https://doaj.org/article/d822e6cfeb8648068ea652e7f3ceda8d
Autor:
Anna Ramisch, Verena Heinrich, Laura V. Glaser, Alisa Fuchs, Xinyi Yang, Philipp Benner, Robert Schöpflin, Na Li, Sarah Kinkley, Anja Römer-Hillmann, John Longinotto, Steffen Heyne, Beate Czepukojc, Sonja M. Kessler, Alexandra K. Kiemer, Cristina Cadenas, Laura Arrigoni, Nina Gasparoni, Thomas Manke, Thomas Pap, John A. Pospisilik, Jan Hengstler, Jörn Walter, Sebastiaan H. Meijsing, Ho-Ryun Chung, Martin Vingron
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-23 (2019)
Abstract We present the software Condition-specific Regulatory Units Prediction (CRUP) to infer from epigenetic marks a list of regulatory units consisting of dynamically changing enhancers with their target genes. The workflow consists of a novel pr
Externí odkaz:
https://doaj.org/article/0837b27a1c654e23a698084a3171e903
Autor:
Abdulrahman Salhab, Karl Nordström, Gilles Gasparoni, Kathrin Kattler, Peter Ebert, Fidel Ramirez, Laura Arrigoni, Fabian Müller, Julia K. Polansky, Cristina Cadenas, Jan G.Hengstler, Thomas Lengauer, Thomas Manke, DEEP Consortium, Jörn Walter
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Partially methylated domains are extended regions in the genome exhibiting a reduced average DNA methylation level. They cover gene-poor and transcriptionally inactive regions and tend to be heterochromatic. We present a comprehen
Externí odkaz:
https://doaj.org/article/cec8d3291de344efa45c4a879e94a5c0
Autor:
Fidel Ramírez, Vivek Bhardwaj, Laura Arrigoni, Kin Chung Lam, Björn A. Grüning, José Villaveces, Bianca Habermann, Asifa Akhtar, Thomas Manke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Although topologically associating domains (TADs) have been extensively investigated, it is not clear to what extent DNA sequence contributes to their formation. Here the authors develop software to identify high-resolution TAD boundaries and reveal
Externí odkaz:
https://doaj.org/article/f48cef696c874fc680f5d90d7c13d700
Autor:
Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1008-1021 (2016)
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-sel
Externí odkaz:
https://doaj.org/article/15acdfef4129450fb67865a1bd83d169
Autor:
Carlos Alfonso-Gonzalez, Ivano Legnini, Sarah Holec, Laura Arrigoni, Hasan Can Ozbulut, Fernando Mateos, David Koppstein, Agnieszka Rybak-Wolf, Ulrike Bönisch, Nikolaus Rajewsky, Valérie Hilgers
Publikováno v:
Cell
The generation of distinct messenger RNA isoforms through alternative RNA processing modulates the expression and function of genes, often in a cell-type-specific manner. Here, we assess the regulatory relationships between transcription initiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be45e3b1161b4456ad8bcfed4150a2f0
http://edoc.mdc-berlin.de/23360/1/23360oa.pdf
http://edoc.mdc-berlin.de/23360/1/23360oa.pdf
Autor:
John Andrew Pospisilik, Ulrike Bönisch, Adelheid Lempradl, Gabriel Seifert, Steffen Heyne, Vanessa Wegert, Laura Arrigoni, Ilaria Panzeri, John Longinotto, Chih-Hsiang Yang
Publikováno v:
Journal of Visualized Experiments
Obesity is a complex disease influenced by genetics, epigenetics, the environment, and their interactions. Mature adipocytes represent the major cell type in white adipose tissue. Understanding how adipocytes function and respond to (epi)genetic and
Autor:
Carlos Alfonso-Gonzalez, Ivano Legnini, Sarah Holec, Laura Arrigoni, Ulrike Bönisch, Agnieszka Rybak-Wolf, Nikolaus Rajewsky, Valerie Hilgers
Publikováno v:
SSRN Electronic Journal.
Autor:
Sophia M. Hochrein, Hao Wu, Miriam Eckstein, Laura Arrigoni, Josip S. Herman, Fabian Schumacher, Christian Gerecke, Mathias Rosenfeldt, Dominic Grün, Burkhard Kleuser, Georg Gasteiger, Wolfgang Kastenmüller, Bart Ghesquière, Jan Van den Bossche, E. Dale Abel, Martin Vaeth
Publikováno v:
Hochrein, S M, Wu, H, Eckstein, M, Arrigoni, L, Herman, J S, Schumacher, F, Gerecke, C, Rosenfeldt, M, Grün, D, Kleuser, B, Gasteiger, G, Kastenmüller, W, Ghesquière, B, van den Bossche, J, Abel, E D & Vaeth, M 2022, ' The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming ', Cell Metabolism, vol. 34, no. 4, pp. 516-532.e11 . https://doi.org/10.1016/j.cmet.2022.02.015
Cell Metab
Cell Metabolism
Cell Metabolism, 34(4), 516-532.e11. Cell Press
Cell Metab
Cell Metabolism
Cell Metabolism, 34(4), 516-532.e11. Cell Press
Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative phosphorylation to aerobic glycolysis provides energy and intermediary metabolites for the biosynthesis of macromolecules to support clonal expansion and effector f