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pro vyhledávání: '"Laura Anne Penny"'
Publikováno v:
Immunity. 42(6):1116-1129
Immune memory cells are poised to rapidly expand and elaborate effector functions upon reinfection yet exist in a functionally quiescent state. The paradigm is that memory T cells remain inactive due to lack of T cell receptor (TCR) stimuli. Here, we
Publikováno v:
Blood. 121:4473-4483
The precise microRNAs and their target cellular processes involved in generation of durable T-cell immunity remain undefined. Here we show a dynamic regulation of microRNAs as CD8 T cells differentiate from naïve to effector and memory states, with
Autor:
Yevgeniy Yuzefpolskiy, Florian Martin Baumann, Laura Anne Penny, Vandana Kalia, Surojit Sarkar
Publikováno v:
The Journal of Immunology. 196:129.6-129.6
PD-1 is highly expressed on CD8 T cells during activation, both in acute and chronic viral infections. Inhibitory signaling in cytotoxic T cells through the PD-1 axis is well characterized during chronic infections and has led to the development of p
Autor:
Yevgeniy Yuzefpolskiy, Laura Anne Penny, Florian Martin Baumann, Kendall A Smith, Surojit Sarkar, Vandana Kalia
Publikováno v:
The Journal of Immunology. 196:133.1-133.1
Proliferation is a defining feature of clonal cytotoxic T lymphocyte (CTL) responses upon activation. However, how proliferative events during primary expansion relate to divergent CD8 T cell fate outcomes remains poorly defined. Emerging evidence fr