Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Laura Amori"'
Publikováno v:
Molecular Informatics. 32:447-457
O-Acetylserine sulfhydrylase (isoform A, OASS-A) is a PLP-dependent enzyme involved in the last step of cysteine biosynthesis in many pathogens. Many microorganisms use cysteine as the main building block for sulfur-containing antioxidants, and cyste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fab8236da4e21eb91b7b929aaab89ff
https://doi.org/10.1002/minf.201200174
https://doi.org/10.1002/minf.201200174
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6401-6404
We have synthesized and evaluated a series of 1,4-disubstituted-triazole derivatives for inhibition of the rat Na(V)1.6 sodium channel isoform, an isoform thought to play an important role in controlling neuronal firing. Starting from a series of 2,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811e707fea21c44134a094c3ad000473
https://doi.org/10.1016/j.bmcl.2012.08.067
https://doi.org/10.1016/j.bmcl.2012.08.067
Publikováno v:
Molecular Informatics. 30:317-328
Serine racemase (SR) is a PLP-dependent enzyme catalyzing the racemization of L-Ser into D-Ser, which is now recognized as an endogenous co-agonist at the NMDA receptor complex. As indicated by available X-ray structures, SR undergoes significant con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c473bfa75b7da59787d7f88b678db65
https://doi.org/10.1002/minf.201000162
https://doi.org/10.1002/minf.201000162
Publikováno v:
Tetrahedron. 65:7092-7098
The metal-catalyzed reactions of neopentyl α-diazomethanesulfonate (DAMS) and diisopropyl α-diazomethanephosphonate (DIDAMP) with furan, 2-methylfuran and 2-methoxyfuran are reported. The products consist mostly of ω-acyl-substituted sulfono- or p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5117d5474515f39c72badc3b5de97b5f
https://doi.org/10.1016/j.tet.2009.06.040
https://doi.org/10.1016/j.tet.2009.06.040
Publikováno v:
Journal of Neurochemistry. 109:316-325
In the mammalian brain, kynurenine aminotransferase II (KAT II) and kynurenine 3-monooxygenase (KMO), key enzymes of the kynurenine pathway of tryptophan degradation, form the neuroactive metabolites kynurenic acid (KYNA) and 3-hydroxykynurenine (3-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dd596bbac3248e6d353e34a19b87e7
https://doi.org/10.1111/j.1471-4159.2009.05893.x
https://doi.org/10.1111/j.1471-4159.2009.05893.x
Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain
Publikováno v:
Journal of Neurochemistry. 102:103-111
The tryptophan metabolite kynurenic acid (KYNA), which is produced enzymatically by the irreversible transamination of l-kynurenine, is an antagonist of alpha7 nicotinic and NMDA receptors and may thus modulate cholinergic and glutamatergic neurotran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb1be2919ddf8e136c8d58917f218eb
https://doi.org/10.1111/j.1471-4159.2007.04556.x
https://doi.org/10.1111/j.1471-4159.2007.04556.x
Publikováno v:
Tetrahedron Letters. 48:4911-4914
A new and efficient synthesis of cis - and trans -aziridine-2-phosphonates by metal-catalyzed aziridination reaction of diisopropyl diazomethylphosphonate and substituted aryl imines is reported. By exploring the influence of different Lewis acids em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445a3aca3db94758ca26655e4030bdde
https://doi.org/10.1016/j.tetlet.2007.05.042
https://doi.org/10.1016/j.tetlet.2007.05.042
Publikováno v:
Journal of Neuroscience Research. 85:845-854
The kynurenine pathway (KP) of tryptophan degradation contains three neuroactive metabolites: the neuroinhibitory agent kynurenic acid (KYNA) and, in a competing branch, the free radical generator 3-hydroxykynurenine (3-HK) and the excitotoxin quinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09617956c4f96b71934ce15cca2bb566
https://doi.org/10.1002/jnr.21183
https://doi.org/10.1002/jnr.21183
Autor:
Peter J. Flor, Ivo Vranesic, Roberto Pellicciari, Gabriele Costantino, Fabrizio Gasparini, Rainer Kuhn, Laura Amori, Maura Marinozzi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1447-1450
On the basis of a pharmacophore definition of mGlu4 agonists, the two novel semi-rigid derivatives 12 and 13 were designed and synthesized. The preliminary biological evaluation demonstrated that both compounds interact with hmGlu4a, while ineffectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030bbad92c59b4818f73ac2d3f74c352
https://doi.org/10.1016/s0960-894x(00)00247-x
https://doi.org/10.1016/s0960-894x(00)00247-x
Autor:
Claudia Beato, Margarita A. Tararina, Gabriele Costantino, Gian Paolo Vallerini, Xiao-Dan Wang, Robert Schwarcz, Laura Amori
Publikováno v:
Journal of medicinal chemistry. 56(23)
3-Hydroxyanthranilic acid 3,4-dioxygenase (3-HAO) is the enzyme responsible for the production of the neurotoxic tryptophan metabolite quinolinic acid (QUIN). Elevated brain levels of QUIN are observed in several neurodegenerative diseases, but pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa93be0caca5e0de63a19903f52e9d0
https://pubmed.ncbi.nlm.nih.gov/24274468
https://pubmed.ncbi.nlm.nih.gov/24274468