Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura Albizu"'
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 9:636-650
Because G protein-coupled receptors (GPCRs) are numerous, widely expressed and involved in major physiological responses, they represent a relevant therapeutic target for drug discovery, particularly regarding pharmacological treatments of neurologic
Autor:
Laura Albizu, Alain Rabié, Thierry Durroux, Bernard Mouillac, Christiane Mendre, Hervé Ansanay, Sanja Perkovska, Hélène Orcel
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2009, 75 (3), pp.637-47. ⟨10.1124/mol.108.049031⟩
Molecular Pharmacology, 2009, 75 (3), pp.637-47. ⟨10.1124/mol.108.049031⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2009, 75 (3), pp.637-47. ⟨10.1124/mol.108.049031⟩
Molecular Pharmacology, 2009, 75 (3), pp.637-47. ⟨10.1124/mol.108.049031⟩
International audience; We show here that the rat vasopressin V(1b) receptor simultaneously activates both the G(q/11)-inositol phosphate (IP) and G(s)-cAMP pathways when transiently expressed in Chinese hamster ovary, human embryonic kidney (HEK) 29
Autor:
Laura Albizu, René Seyer, Maurice Manning, Thierry Durroux, Géraldine Teppaz, Hervé Ansanay, Herve Bazin, Bernard Mouillac
Publikováno v:
Journal of Medicinal Chemistry. 50:4976-4985
A series of fluorescent ligands designed for vasopressin and oxytocin G protein-coupled receptors was synthesized and characterized to develop fluorescence polarization or homogeneous time-resolved fluorescence (HTRF) binding assays. These ligands, l
Autor:
Claude Barberis, Maurice Manning, Thierry Durroux, Marie-Noëlle Balestre, Christophe Breton, Laura Albizu, Jean-Philippe Pin, Bernard Mouillac
Publikováno v:
Molecular Pharmacology. 70:1783-1791
An increasing amount of ligand binding data on G protein-coupled receptors (GPCRs) is not compatible with the prediction of the simple mass action law. This may be related to the propensity of most GPCRs, if not all, to oligomerize. Indeed, one of th
Autor:
Martin, Cottet, Laura, Albizu, Laetitia, Comps-Agrar, Eric, Trinquet, Jean-Philippe, Pin, Bernard, Mouillac, Thierry, Durroux
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 746
G protein-coupled receptors (GPCRs) play a key role in the regulation of physiological functions. Deregulation of their activities often results in pathological disorders and therefore these receptors constitute major targets for drug development. Th
Publikováno v:
Neuropharmacology. 61(4)
The serotonin 5-HT(2A) receptor (5-HT(2A)R) and dopamine D(2) receptor (D(2)R) are high-affinity G protein-coupled receptor targets for two different classes of antipsychotic drugs used to treat schizophrenia. Interestingly, the antipsychotic effects
Autor:
Jean-Philippe Pin, Laetitia Comps-Agrar, Thierry Durroux, Martin Cottet, Bernard Mouillac, Eric Trinquet, Laura Albizu
Publikováno v:
Methods in Molecular Biology ISBN: 9781617791253
G protein-coupled receptors (GPCRs) play a key role in the regulation of physiological functions. Deregulation of their activities often results in pathological disorders and therefore these receptors constitute major targets for drug development. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28baf80dc3fbcde2d405ae5782a849e1
https://doi.org/10.1007/978-1-61779-126-0_21
https://doi.org/10.1007/978-1-61779-126-0_21
Autor:
Laura Albizu, Adrienne Umali, José L. Moreno, Marta Filizola, Miguel Fribourg, Diomedes E. Logothetis, Vladimir Brezina, Terrell Holloway, Rahul Mahajan, Alexandre Fabiato, Stuart C. Sealfon, Candice N. Hatcher, Jihyun Shim, Lia Baki, Jose M. Eltit, Davide Provasi, Alexander D. MacKerell, Gyu Park, Javier González-Maeso, Zheng Li, Jeffrey D. Ruta, Scott K. Adney
Publikováno v:
Cell. 147(5)
Summary Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT 2A G protein-coupled receptor (GPCR), the 2AR, which signals via a G q heterotrimeric G protein. The closely related non-antipsychoti
Publikováno v:
Neuroscience letters. 493(3)
Hallucinogenic drugs, including mescaline, psilocybin and lysergic acid diethylamide (LSD), act at serotonin 5-HT2A receptors (5-HT2ARs). Metabotropic glutamate receptor 2/3 (mGluR2/3) ligands show efficacy in modulating the responses induced by acti
Autor:
Isabelle Brabet, Martin Cottet, Thierry Durroux, Laura Albizu, Stoytcho Stoev, Maurice Manning, Laurent Lamarque, Jean-Philippe Pin, Eric Trinquet, René Seyer, Thomas Roux, Amy Hauck Newman, Michaela Kralikova, Marie-Laure Rives, Bernard Mouillac, Herve Bazin, Jonathan A. Javitch, Christophe Breton, Emmanuel Bourrier
Publikováno v:
Nature chemical biology. 6(8)
G protein–coupled receptor (GPCR) oligomers have been proposed to play critical roles in cell signaling, but confirmation of their existence in a native context remains elusive, as no direct interactions between receptors have been reported. To dem