Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura Ajram"'
Autor:
Charlotte M. Pretzsch, Dorothea L. Floris, Bogdan Voinescu, Malka Elsahib, Maria A. Mendez, Robert Wichers, Laura Ajram, Glynis Ivin, Martin Heasman, Elise Pretzsch, Steven Williams, Declan G. M. Murphy, Eileen Daly, Gráinne M. McAlonan
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Background Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms are lacking. To expand intervention options, it is crucial to gain a better understanding of potential treatment
Externí odkaz:
https://doaj.org/article/bcb737c5aea84c9a8d1f5e0526e9625b
Autor:
Laura Ajram
Publikováno v:
European Neuropsychopharmacology. 63:e319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71fb91ef1dac9d4d848f5c97130be547
https://doi.org/10.1016/j.euroneuro.2022.07.573
https://doi.org/10.1016/j.euroneuro.2022.07.573
Autor:
Robert Wichers, Declan G. Murphy, Glynis Ivin, Bogdan Voinescu, Maria Andreina Mendez, Dorothea L. Floris, Charlotte M. Pretzsch, Martin Heasman, Eileen Daly, Grainne M. McAlonan, Malka Elsahib, Elise Pretzsch, Steven Williams, Laura Ajram
Publikováno v:
Pretzsch, C M, Floris, D L, Voinescu, B, Elsahib, M, Mendez, M A, Wichers, R, Ajram, L, Ivin, G, Heasman, M, Pretzsch, E, Williams, S, Murphy, D G M, Daly, E & McAlonan, G M 2021, ' Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin ', Molecular Autism, vol. 12, no. 1, 49 . https://doi.org/10.1186/s13229-021-00454-6
Molecular Autism
Molecular Autism, 12
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Molecular Autism, 12, 1
Molecular Autism
Molecular Autism, 12
Molecular Autism, Vol 12, Iss 1, Pp 1-14 (2021)
Molecular Autism, 12, 1
Background Autism spectrum disorder (ASD) has a high cost to affected individuals and society, but treatments for core symptoms are lacking. To expand intervention options, it is crucial to gain a better understanding of potential treatment targets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab6ea3363f7abae7e70e2c9ce46a7ef
https://doi.org/10.1186/s13229-021-00454-6
https://doi.org/10.1186/s13229-021-00454-6
Autor:
Eileen Daly, Laura Ajram, Martin Heasman, Maria Andreina Mendez, Charlotte M. Pretzsch, Robert Wichers, Grainne M. McAlonan, Glynis Ivin, Steven Williams, Bogdan Voinescu, Declan G. Murphy
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Journal of Psychopharmacology
Pretzsch, C M, Voinescu, B, Mendez, M A, Wichers, R, Ajram, L, Ivin, G, Heasman, M, Williams, S, Murphy, D GM, Daly, E & McAlonan, G M 2019, ' The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD) ', Journal of Psychopharmacology, vol. 33, no. 9, pp. 1141-1148 . https://doi.org/10.1177/0269881119858306
Journal of Psychopharmacology
Pretzsch, C M, Voinescu, B, Mendez, M A, Wichers, R, Ajram, L, Ivin, G, Heasman, M, Williams, S, Murphy, D GM, Daly, E & McAlonan, G M 2019, ' The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD) ', Journal of Psychopharmacology, vol. 33, no. 9, pp. 1141-1148 . https://doi.org/10.1177/0269881119858306
Background: The potential benefits of cannabis and its major non-intoxicating component cannabidiol (CBD) are attracting attention, including as a potential treatment in neurodevelopmental disorders such as autism spectrum disorder (ASD). However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612119b9791bce1fdee907166f4e93c9
https://doi.org/10.1177/0269881119858306
https://doi.org/10.1177/0269881119858306
Autor:
Glynis Ivin, Eileen Daly, Richard A.E. Edden, David J. Lythgoe, Grainne M. McAlonan, Steven Williams, Maria Andreina Mendez, Laura Ajram, Rob Wichers, Bogdan Voinescu, Charlotte M. Pretzsch, Declan G. Murphy, Martin Heasman, Jamie Horder
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-10 (2019)
Translational Psychiatry, Vol 9, Iss 1, Pp 1-10 (2019)
Autism spectrum disorder (ASD) is a high cost neurodevelopmental condition; and there are currently no effective pharmacological treatments for its core symptoms. This has led some families and researchers to trial alternative remedies – including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d435bafe6acddda4e85ba7c93448f1fa
https://doi.org/10.1038/s41398-019-0654-8
https://doi.org/10.1038/s41398-019-0654-8
Autor:
Andreia Carvalho Pereira, Alice M. S. Durieux, Marija M. Petrinovic, Grainne M. McAlonan, Laura Ajram, Hester E. Velthius
Publikováno v:
Ajram, L, Carvalho Pereira, A, Durieux, A, Velthuis, H, Petrinovic, M-M & McAlonan, G M 2019, ' The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism ', Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 89, pp. 236-244 . https://doi.org/10.1016/j.pnpbp.2018.09.010
Autism spectrum disorder (ASD) affects over 1:100 of the population and costs the UK more than £32bn and the USA more than $175bn (£104bn) annually. Its core symptoms are social and communication difficulties, repetitive behaviours and sensory hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0805a77794a5032f40050f95aa2481
https://kclpure.kcl.ac.uk/en/publications/e253c2e5-ea1d-4a3d-83c7-6add57a6228c
https://kclpure.kcl.ac.uk/en/publications/e253c2e5-ea1d-4a3d-83c7-6add57a6228c
Autor:
Grainne M. McAlonan, Eileen Daly, Charlotte M. Pretzsch, Richard A.E. Edden, Maria Andreina Mendez, Declan G. Murphy, Glynis Ivin, Martin Heasman, Jamie Horder, Jan Freyberg, David J. Lythgoe, Steven Williams, Laura Ajram, Bogdan Voinescu, Robert Wichers
Publikováno v:
Neuropsychopharmacology
There is increasing interest in the use of cannabis and its major non-intoxicating component cannabidiol (CBD) as a treatment for mental health and neurodevelopmental disorders, such as autism spectrum disorder (ASD). However, before launching large-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de2f0423f0e0bcbefa5957a33442254
Autor:
Janneke Zinkstok, Richard A.E. Edden, Clodagh M. Murphy, Declan G. Murphy, Scr Williams, A. Galanopoulos, David J. Lythgoe, Laura Ajram, Grainne M. McAlonan, Mark D. Tricklebank, Maria Andreina Mendez, L P Brennan, Gareth J. Barker, Martin Heasman, Dene Robertson, Jamie Horder, D. Meek, Glynis Ivin, Robert Wichers
Publikováno v:
Ajram, L A, Horder, J, Mendez, M A, Galanopoulos, A, Brennan, L P, Wichers, R H, Robertson, D M, Murphy, C M, Zinkstok, J, Ivin, G, Heasman, M, Meek, D, Tricklebank, M D, Barker, G J, Lythgoe, D J, Edden, R A E, Williams, S C, Murphy, D G M & McAlonan, G M 2017, ' Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder ', Translational psychiatry, vol. 7, no. 5, e1137, pp. 1-7 . https://doi.org/10.1038/tp.2017.104
Translational Psychiatry
Translational Psychiatry
Currently, there are no effective pharmacologic treatments for the core symptoms of autism spectrum disorder (ASD). There is, nevertheless, potential for progress. For example, recent evidence suggests that the excitatory (E) glutamate and inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31c710d8bd279b078c306d96093ea38
https://kclpure.kcl.ac.uk/en/publications/47d9b46d-8211-4ca9-b89c-5214a35e9c8a
https://kclpure.kcl.ac.uk/en/publications/47d9b46d-8211-4ca9-b89c-5214a35e9c8a
Autor:
Laura Ajram, Mark D. Tricklebank
Publikováno v:
Integrative Neuroscience Research.
The 1950s heralded a golden age for psychiatric drug discovery; for the first time, compounds capable of treating serious mental disturbances were found that, despite their shortcomings, proved the pharmacotherapy of mental disorders was both possibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb391b282d289881f6e011315265cb4d
https://doi.org/10.35841/neuroscience.1.1.1-4
https://doi.org/10.35841/neuroscience.1.1.1-4
Autor:
Jonathan M. Percy, Simon Teanby Hodgson, Sean M. Lynn, Brian Evans, Panayiotis A. Procopiou, Rebecca H. Graves, Laura Ajram, Stephen A. Richards, Afjal Hussain Miah, Malcolm Begg, Robert J. Slack, Lena Shukla
A number of potent 2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine CCR4 antagonists binding to the extracellular allosteric site were synthesised. (R)-N-(2,4-Dichlorobenzyl)-2-(2-(pyrrolidin-2-ylmethyl)-2,8-diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e553624afbf87efcffffc8f5b3ffa92
https://strathprints.strath.ac.uk/57543/1/Shukla_etal_EJMC2016_2_8_Diazaspiro_4.5_decan_8_yl_pyrimidin_4_amine_potent_CCR4.pdf
https://strathprints.strath.ac.uk/57543/1/Shukla_etal_EJMC2016_2_8_Diazaspiro_4.5_decan_8_yl_pyrimidin_4_amine_potent_CCR4.pdf