Výsledky vyhledávání - "Laura Ahtiainen"

Akademický článek

Live Tissue Imaging Sheds Light on Cell Level Events During Ectodermal Organ Development

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Embryonic development of ectodermal organs involves a very dynamic range of cellular events and, therefore, requires advanced techniques to visualize them. Ectodermal organogenesis proceeds in well-defined sequential stages mediated by tissue interac

Externí odkaz: https://doaj.org/article/d13e710d8d87470481ee46c8259a8c9d

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Akademický článek

Palmitoyl protein thioesterase 1 (Ppt1)-deficient mouse neurons show alterations in cholesterol metabolism and calcium homeostasis prior to synaptic dysfunction

Autor: Laura Ahtiainen, Julia Kolikova, Aino-Liisa Mutka, Kaisu Luiro, Massimiliano Gentile, Elina Ikonen, Leonard Khiroug, Anu Jalanko, Outi Kopra

Publikováno v: Neurobiology of Disease, Vol 28, Iss 1, Pp 52-64 (2007)

Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of children, characterized by selective death of neocortical neurons. To understand early disease mechanisms in INCL, we have studied Ppt1Deltaex4 knock-out mouse

Externí odkaz: https://doaj.org/article/aa3440668f314b2eabfc140a5328b79c

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Akademický článek

Defects in innate immunity render breast cancer initiating cells permissive to oncolytic adenovirus.

Autor: Laura Ahtiainen, Cristina Mirantes, Tiina Jahkola, Sophie Escutenaire, Iulia Diaconu, Pamela Osterlund, Anna Kanerva, Vincenzo Cerullo, Akseli Hemminki

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13859 (2010)

BackgroundCancer stem cells/initiating cells (CSC/CIC), are thought to exist as a small population in malignant tissues. They are resistant to conventional cancer treatments and possibly underlie post-treatment relapse. The CIC population can be targ

Externí odkaz: https://doaj.org/article/e980cd7d5ead401aa6fc1c566dc14e69

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Data from Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Purpose: Twenty-one patients with cancer were treated with a single round of oncolytic adenovirus ICOVIR-7.Experimental Design: ICOVIR-7 features an RGD-4C modification of the fiber HI-loop of serotype 5 adenovirus for enhanced entry into tumor cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4690c59ab3fc089b2d78b3976ce4f61e
https://doi.org/10.1158/1078-0432.c.6519620.v1

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Supplementary Data from Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Supplementary Data from Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dac9713699d888131aa5a3f7e6bccef
https://doi.org/10.1158/1078-0432.22443029.v1

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Supplementary Figures 1-6, Tables 1-3 from Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Supplementary Figures 1-6, Tables 1-3 from Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3fd4d16c14accdf6ea224f0b9fbffa
https://doi.org/10.1158/0008-5472.22382853.v1

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Data from Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell–killing can produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6efec3e0071e39f6ff93a11794299eb
https://doi.org/10.1158/0008-5472.c.6500337

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Foxi3 Suppresses Signaling Center Fate and is Necessary for the Early Development of Mouse Teeth

Autor: Isabel Mogollón, Niko Kangasniemi, Jacqueline Emmanuel Moustakas-Verho, Laura Ahtiainen

Tooth morphogenesis is regulated by ectodermal-mesenchymal interactions which are controlled by reiteratively used, evolutionarily conserved pathways. How these signals translate into different cellular behaviors is beginning to be understood. Embryo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aeda38897b7e0fdcd3b29d58d8f72ba8
https://doi.org/10.1101/2022.07.18.500404

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Live Tissue Imaging Sheds Light on Cell Level Events During Ectodermal Organ Development

Autor: Laura Ahtiainen, Isabel Mogollón

Publikováno v: Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8a4a638ee4f0fe91d273ae341ff086
https://pubmed.ncbi.nlm.nih.gov/32765297

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The Initiation Knot is a Signaling Center Required for Molar Tooth Development

Autor: Jacqueline E. Moustakas-Verho, Minna Niittykoski, Laura Ahtiainen, Isabel Mogollón

Publikováno v: Development (Cambridge, England)
article-version (VoR) Version of Record

Signaling centers, or organizers, regulate many aspects of embryonic morphogenesis. In the mammalian molar tooth, reiterative signaling in specialized centers called enamel knots (EKs) determines tooth patterning. Preceding the primary EK, transient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd7886b8917c76de0b36e9821ebce2b

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