Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura Abelleira-Hervas"'
Autor:
Shahmir Naseer, Laura Abelleira-Hervas, Dhwani Savani, Ross de Burgh, Robertas Aleksynas, Cornelius K. Donat, Nelofer Syed, Magdalena Sastre
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1457 (2022)
There is compelling evidence that head injury is a significant environmental risk factor for Alzheimer’s disease (AD) and that a history of traumatic brain injury (TBI) accelerates the onset of AD. Amyloid-β plaques and tau aggregates have been ob
Externí odkaz:
https://doaj.org/article/d9bb739aeae34cddb8183f5d92e8afe6
Autor:
Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J.I. Blackford, Laura Abelleira-Hervas, Robert D. Sampson, Ian O. Shum, Matthew J. Branch, Peter J. Gardner, Jane C. Sowden, James W.B. Bainbridge, Alexander J. Smith, Emma L. West, Rachael A. Pearson, Robin R. Ali
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 820-837 (2017)
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that
Externí odkaz:
https://doaj.org/article/8a49ca1b0cdf4a038147dab24006d255
Autor:
Izabela P. Klaska, Anne White, Pilar Villacampa, Justin Hoke, Laura Abelleira-Hervas, Ryea N. Maswood, Robin R. Ali, Catey Bunce, Richard D. Unwin, Garth J.S. Cooper, Paul N. Bishop, James W. Bainbridge
Publikováno v:
Experimental eye research. 215
Opticin is an extracellular glycoprotein present in the vitreous. Its antiangiogenic properties offer the potential for therapeutic intervention in conditions such as proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba65723c142b05f6e6d24f249ca9bc8
https://pubmed.ncbi.nlm.nih.gov/34954204
https://pubmed.ncbi.nlm.nih.gov/34954204
Autor:
Robin R. Ali, Maeve Barlow, James W B Bainbridge, Enrico Cristante, Sidath E. Liyanage, Yanai Duran, Pilar Villacampa, Katja E. Menger, Laura Abelleira-Hervas, Izabela P Klaska, Robert D. Sampson, Ulrich F O Luhmann, Alexander J. Smith
Publikováno v:
Angiogenesis
The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4be75f902f05fb55817fdb604bd569
https://doi.org/10.1007/s10456-019-09681-1
https://doi.org/10.1007/s10456-019-09681-1
Autor:
Eduardo Zabala Aldunate, Valentina Di Foggia, Fabiana Di Marco, Laura Abelleira Hervas, Joana Claudio Ribeiro, Daniel L. Holder, Aara Patel, Tommaso B. Jannini, Dorothy A. Thompson, Juan Pedro Martinez-Barbera, Rachael A. Pearson, Robin R. Ali, Jane C. Sowden
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Irreversible photoreceptor cell death is a major cause of blindness in many retinal dystrophies. A better understanding of the molecular mechanisms underlying the progressive loss of photoreceptor cells remains therefore crucial. Abnormal expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::caf6cf350e90dc2bca119eb8c529195e
http://link.springer.com/article/10.1038/s41598-018-38294-9
http://link.springer.com/article/10.1038/s41598-018-38294-9
Autor:
Bibiana C. Mota, Nathan Ashburner, Laura Abelleira-Hervas, Liyueyue Liu, Robertas Aleksynas, Lucio Claudio Rovati, Gianfranco Caselli, Magdalena Sastre
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7320
Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in animal models of neurodegeneration, such as Alzheimer’s disease (AD). We recently demonstrated that the I2-ligand BU224 reversed memory impairments in AD transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba47d7ee129c17b48fa0b829f38537c
https://doi.org/10.3390/ijms23137320
https://doi.org/10.3390/ijms23137320
Autor:
James A Pickering, Nicoleta Baxan, Cornelius K. Donat, Steve M. Gentleman, Laura Abelleira-Hervas, Marc H. Goldfinger, Egle Solito, Tsz Wing Chau, Chris P. M. Reutelingsperger, Magdalena Sastre, Antonio d'Amati, Maria Yanez Lopez, Brinda Gurung, Robertas Aleksynas, Soha Jamshed Iqbal, Carmen Romero-Molina, Gerard Hernandez-Mir, Miriam Ries, Fred Van Leuven, Annika Semmler, Helena R. Watts, Bibiana C. Mota
Publikováno v:
Brain, 144, 1526-1541. Oxford University Press
Brain
Brain
Alzheimer’s disease, characterized by brain deposits of amyloid-β plaques and neurofibrillary tangles, is also linked to neurovascular dysfunction and blood–brain barrier breakdown, affecting the passage of substances into and out of the brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0631e1fed5de1dd25d8be53ed27d84
http://hdl.handle.net/10044/1/86223
http://hdl.handle.net/10044/1/86223
Autor:
Joana Ribeiro, Robert D. Sampson, Ulrich F O Luhmann, Matteo Rizzi, Anastasios Georgiadis, Robin R. Ali, Selina A. Azam, Justin Hoke, Ryea Maswood, Sophia-Martha Kleine Holthaus, Rachael A. Pearson, Laura Abelleira-Hervas, Sara E. Mole, Alexander J. Smith, Yanai Duran
Publikováno v:
Molecular Therapy
The neuronal ceroid lipofuscinoses (NCLs) are inherited lysosomal storage disorders characterized by general neurodegeneration and premature death. Sight loss is also a major symptom in NCLs, severely affecting the quality of life of patients, but it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835a4e2364e6a599c31e2e0669a17678
Autor:
Maria Balaet, Rita Campos-Pires, Phillip Aitken, Nicholas P. Franks, Nada Mohamed-Ali, Robert Dickenson, Jitka Aldhoun, Christopher J. Edge, Laura Abelleira-Hervas
Publikováno v:
British Journal of Anaesthesia. 123:e508-e509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9774a593132be2db3402526b50c80ad8
https://doi.org/10.1016/j.bja.2019.04.033
https://doi.org/10.1016/j.bja.2019.04.033
Autor:
Livia S. Carvalho, Robin R. Ali, Laura Abelleira Hervas, Ulrich F O Luhmann, Philipp Herrmann, Enrico Cristante, James W B Bainbridge, Yanai Duran, Jill A. Cowing, Sidath E. Liyanage, Joana Ribeiro
Publikováno v:
Neurobiology of Aging. 36:2637-2648
Dysregulation of the complement system has been implicated in the pathogenesis of age-related macular degeneration. To investigate consequences of altered complement regulation in the eye with age, we examined Cd59a complement regulator deficient (Cd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1861a2daffe1995b5c551a01a08c99ef
https://doi.org/10.1016/j.neurobiolaging.2015.05.019
https://doi.org/10.1016/j.neurobiolaging.2015.05.019