Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura A. Tollini"'
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse models have demonstr
Externí odkaz:
https://doaj.org/article/ab4d8b9a3cc049ec95dfccafa7607574
Autor:
Melissa M Keenan, Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D Stevens, Olga Ilkayeva, Zhiqing Huang, Laura A Tollini, Susan K Murphy, Joseph Lucas, Deborah M Muoio, So Young Kim, Jen-Tsan Chi
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005599 (2015)
In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, w
Externí odkaz:
https://doaj.org/article/0d3f4fffafb2491ca3549fa1521250a2
Publikováno v:
Cancer Cell. 26:235-247
Summary Mdm2 E3 ubiquitin ligase-mediated p53 degradation is generally accepted as the major mechanism for p53 regulation; nevertheless, the in vivo significance of this function has not been unequivocally established. Here, we have generated an Mdm2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d989cbce8011f382eaa5756718e2c4b9
https://doi.org/10.1016/j.ccr.2014.06.006
https://doi.org/10.1016/j.ccr.2014.06.006
Autor:
Yanping Zhang, Laura A. Tollini
Publikováno v:
Genes & Cancer. 3:219-225
Classically, p53 is considered to be an overarching tumor suppressor gene, important in its role as a transcription factor for a number of genes critical for cell cycle arrest, apoptosis, and senescence. More recently, the scope of p53 function has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed09c01aae9f82e4d4a59ed42ac5f92
https://doi.org/10.1177/1947601912454732
https://doi.org/10.1177/1947601912454732
Autor:
Derek D. Cyr, Jen-Tsan Chi, Olga Ilkayeva, Melissa M. Keenan, Zhiqing Huang, Xiaohu Tang, Joseph Lucas, Jianli Wu, Laura A. Tollini, Beiyu Liu, Robert Stevens, Deborah M. Muoio, So Young Kim, Susan K. Murphy
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 11, Iss 10, p e1005599 (2015)
PLoS Genetics, Vol 11, Iss 10, p e1005599 (2015)
In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09cb3a7c5c81518cf6d0dfe73932985
http://europepmc.org/articles/PMC4599891
http://europepmc.org/articles/PMC4599891
Autor:
Patrick L. Leslie, Lee M. Graves, Yong Liu, J Di, Hilary V. Clegg, Yanping Zhang, Junnian Zheng, Aiwen Jin, T-H Kim, Yizhou He, Laura A. Tollini
Mitochondrial outer membrane permeabilization (MOMP) is a critical control point during apoptosis that results in the release of pro-apoptotic mitochondrial contents such as cytochrome c. MOMP is largely controlled by Bcl-2 family proteins such as Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed0664fe75fd4710ac8b88a297be771
https://europepmc.org/articles/PMC4423185/
https://europepmc.org/articles/PMC4423185/
Autor:
Yong Q. Chen, Patrick L. Leslie, Lei O. Li, Lishi Zhou, Jeffrey M. Macdonald, Rosalind A. Coleman, Laura A. Tollini, Yizhou He, Zhennan Gu, Tae-Hyung Kim, Aiwen Jin, Lee M. Graves, Yong Liu, Andrey P. Tikunov, Yanping Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(23)
The tumor suppressor p53 has recently been shown to regulate energy metabolism through multiple mechanisms. However, the in vivo signaling pathways related to p53-mediated metabolic regulation remain largely uncharacterized. By using mice bearing a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eb3d72951ba615361bae43f092e6d3
https://pubmed.ncbi.nlm.nih.gov/24872453
https://pubmed.ncbi.nlm.nih.gov/24872453
The Mdm2 proto-oncoprotein is the primary negative regulator for p53. While it is believed that Mdm2 degradation is regulated via its own E3 ubiquitin ligase activity, recent development of knock-in mouse models demonstrates that Mdm2 E3 ligase funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114a55e0f2fe89bb2a6220004ff60a86
https://europepmc.org/articles/PMC4111701/
https://europepmc.org/articles/PMC4111701/
Publikováno v:
The Nucleolus ISBN: 9781461405139
The TP53 tumor suppressor gene and its protein product p53, play a critical role in the cellular stress response. Upon exposure to stressors, such as DNA damage, oncogene activation, or perturbations to the ribosome biogenesis, p53 is activated and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::171dc047778cf773b66e0c4bb6d07199
https://doi.org/10.1007/978-1-4614-0514-6_12
https://doi.org/10.1007/978-1-4614-0514-6_12
The transcription factor p53 plays a critical role in maintaining homeostasis as it relates to cellular growth, proliferation, and metabolism. In an effort to identify novel p53 target genes, a microarray approach was utilized to identify DHRS3 (also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9668b525308444fa1c8bdcecba1afb8c