Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Laura A. Pike"'
Autor:
William M. Wood, Vibha Sharma, Kevin T. Bauerle, Laura A. Pike, Qiong Zhou, Deborah L. Fretwell, Rebecca E. Schweppe, Bryan R. Haugen
Publikováno v:
PPAR Research, Vol 2011 (2011)
Undifferentiated (anaplastic) thyroid cancer (ATC) is one of the most aggressive human malignancies and no effective therapy is currently available. We show here that PPARγ levels are elevated in cells derived from ATC. Depletion of PPARγ in HTh74
Externí odkaz:
https://doaj.org/article/73f136048bcd471a8389a23be980c795
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
BCPAP and 8505C cells were plated in 96-well plates with or without fibronectin and exposed to the indicated concentrations of PF-573,228 for 5 days. Results shown are mean percent growth {plus minus} SD of 2 experiments performed in triplicate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047b4cf543661692987a5af93942c204
https://doi.org/10.1158/1541-7786.22514751.v1
https://doi.org/10.1158/1541-7786.22514751.v1
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
BCPAP and 8505C cells exposed to (A) 1uM PF-573,228 for 24 hours or those expressing (B) shFAK were assessed for migration through Matrigel-coated transwell chambers. Invaded cells treated with DMSO control or those expressing scrambled control were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053abadcab3febf1c953a09a1cb887ee
https://doi.org/10.1158/1541-7786.22514745
https://doi.org/10.1158/1541-7786.22514745
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
Viability of thyroid cancer cells treated with 1µM PF-573,228 for 6 days was normalized to DMSO-treated cells, set to 100%. Results are % viable cells per mL {plus minus} SD of at least 2 experiments performed in triplicate (t-test: C643, K1, THJ11T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4067fe7e4260588f42106f3fcdb7a384
https://doi.org/10.1158/1541-7786.22514748
https://doi.org/10.1158/1541-7786.22514748
Autor:
Bryan R. Haugen, James A. Fagin, Jeffrey A. Knauf, Iñigo Landa, Daniel V. LaBarbera, Philip Reigan, Maria B. Albuja-Cruz, Christopher Raeburn, Umarani Pugazhenthi, Vibha Sharma, Sharon B. Sams, Qiong Zhou, Christopher Korch, Laura A. Pike, Nikita Pozdeyev, Rebecca E. Schweppe
Electropherograms of the CUTC5, CUTC48, CUTC60 and CUTC61 cell line, PDX, and patient samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217c351ac513de8c219d6acdec51feea
https://doi.org/10.1158/1541-7786.22512805.v1
https://doi.org/10.1158/1541-7786.22512805.v1
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
IHC staining on (A) BCPAP and (B) 8505C orthotopic thyroid tumors for CD34, an endothelial cell marker, was performed on sections of each tumor. Sections were examined under low magnification for representative areas of tumor. Three 20x fields were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9aaedba4c8b1e27617d9782e0ba803
https://doi.org/10.1158/1541-7786.22514739.v1
https://doi.org/10.1158/1541-7786.22514739.v1
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
IHC staining on (A) BCPAP and (B) 8505C orthotopic thyroid tumors for Ki67, a marker of cellular proliferation, was performed on sections of each tumor. The percent of Ki67 positive cells was scored. Results are % Ki67 {plus minus} SEM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7811f253a55cb8a2b9cf3aa7e9a5cec5
https://doi.org/10.1158/1541-7786.22514742.v1
https://doi.org/10.1158/1541-7786.22514742.v1
Autor:
Bryan R. Haugen, James A. Fagin, Jeffrey A. Knauf, Iñigo Landa, Daniel V. LaBarbera, Philip Reigan, Maria B. Albuja-Cruz, Christopher Raeburn, Umarani Pugazhenthi, Vibha Sharma, Sharon B. Sams, Qiong Zhou, Christopher Korch, Laura A. Pike, Nikita Pozdeyev, Rebecca E. Schweppe
Kinase inhibitor sensitivity of the CUTC cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406fc7355289cc9a71e9fb0294a47e7b
https://doi.org/10.1158/1541-7786.22512796.v1
https://doi.org/10.1158/1541-7786.22512796.v1
Autor:
Bryan R. Haugen, James A. Fagin, Jeffrey A. Knauf, Iñigo Landa, Daniel V. LaBarbera, Philip Reigan, Maria B. Albuja-Cruz, Christopher Raeburn, Umarani Pugazhenthi, Vibha Sharma, Sharon B. Sams, Qiong Zhou, Christopher Korch, Laura A. Pike, Nikita Pozdeyev, Rebecca E. Schweppe
Cancer cell lines are critical models to study tumor progression and response to therapy. In 2008, we showed that approximately 50% of thyroid cancer cell lines were redundant or not of thyroid cancer origin. We therefore generated new authenticated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377eba921f466cdd391bfacc53f95f61
https://doi.org/10.1158/1541-7786.c.6540337.v1
https://doi.org/10.1158/1541-7786.c.6540337.v1
Autor:
Rebecca E. Schweppe, Sharon B. Sams, Anna A. Kerege, Laura A. Pike, Xia Jing, Qiong Zhou, Vibha Sharma, Brittelle E. Kessler
Ki67 staining of 8505C shFAK and Scrambled orthotopic thyroid tumors was performed. Proliferation was measured by the percent of Ki67 positive cells scored by a pathologist. Results are % Ki67 {plus minus} SEM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dceb639d1b5216ba0afbad93c37c9c
https://doi.org/10.1158/1541-7786.22514736
https://doi.org/10.1158/1541-7786.22514736