Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Laura A. Nguyen"'
Autor:
Rayk Behrendt, Tina Schumann, Alexander Gerbaulet, Laura A. Nguyen, Nadja Schubert, Dimitra Alexopoulou, Ursula Berka, Stefan Lienenklaus, Katrin Peschke, Kathrin Gibbert, Sabine Wittmann, Dirk Lindemann, Siegfried Weiss, Andreas Dahl, Ronald Naumann, Ulf Dittmer, Baek Kim, Werner Mueller, Thomas Gramberg, Axel Roers
Publikováno v:
Cell Reports, Vol 4, Iss 4, Pp 689-696 (2013)
Aicardi-Goutières syndrome (AGS), a hereditary autoimmune disease, clinically and biochemically overlaps with systemic lupus erythematosus (SLE) and, like SLE, is characterized by spontaneous type I interferon (IFN) production. The finding that defe
Externí odkaz:
https://doaj.org/article/3b719500961e46f0b6f1cf54a33b8cf3
Autor:
Chih-Jen Wei, Wei Bu, Laura A. Nguyen, Joseph D. Batchelor, JungHyun Kim, Stefania Pittaluga, James R. Fuller, Hanh Nguyen, Te-Hui Chou, Jeffrey I. Cohen, Gary J. Nabel
Publikováno v:
Science Translational Medicine. 14
Epstein-Barr virus (EBV) is the major cause of infectious mononucleosis and is associated with several human cancers and, more recently, multiple sclerosis. Despite its prevalence and health impact, there are currently no vaccines or treatments. Four
Autor:
Chih-Jen Wei, Wei Bu, Laura A. Nguyen, Joseph D. Batchelor, JungHyun Kim, Stefania Pittaluga, James R. Fuller, Hanh Nguyen, Te-Hui Chou, Jeffrey I. Cohen, Gary J. Nabel
Epstein Barr virus (EBV) is the major cause of infectious mononucleosis and is associated with several human cancers. Despite its prevalence and major impact on human health, there are currently no specific vaccines or treatments. Four viral glycopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4353c38ffbd8729ebfafd80a3dae4f04
https://doi.org/10.1101/2022.01.18.476774
https://doi.org/10.1101/2022.01.18.476774
Publikováno v:
Proceedings of the National Academy of Sciences. 114:1021-1026
Small self-cleaving ribozymes have been discovered in all evolutionary domains of life. They can catalyze site-specific RNA cleavage, and as a result, they have relevance in gene regulation. Comparative genomic analysis has led to the discovery of a
Autor:
Laura A Nguyen, Peng Zhan, Yang Yang, Zachary B. Smithline, Dongwei Kang, Xinyong Liu, Christophe Pannecouque, Thomas A. Steitz
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Rapid generation of drug-resistant mutations in HIV-1 reverse transcriptase (RT), a prime target for anti-HIV therapy, poses a major impediment to effective anti-HIV treatment. Our previous efforts have led to the development of two novel non-nucleos
Autor:
Laura A. Nguyen, Akash Bhattacharya, Aine McCabe, Felipe Diaz-Griffero, Borries Demeler, Cindy Buffone, Caitlin Shepard, Dmitri N. Ivanov, Baek Kim, Sammy Pardo, Tommy E. White, Zhonghua Wang, Susan T. Weintraub
Publikováno v:
Cell reports
SUMMARY SAMHD1 is a dNTP triphosphohydrolase (dNTPase) that impairs retroviral replication in a subset of noncycling immune cells. Here we show that SAMHD1 is a redox-sensitive enzyme and identify three redox-active cysteines within the protein: C341
Autor:
Manja Burggraf, Oliver T. Keppler, Margarethe Martin, Oliver T. Fackler, Gina M. Lenzi, Ina Ambiel, Efrem S. Lim, Libin Abraham, Xiaoyu Pan, Hanna Mari Baldauf, Laura A. Nguyen, Maud Trotard, Frank Rutsch, Michael Emerman, Sarah Marie Schwarz, Baek Kim, Renate König, Oliver I. Fregoso, Lena Stegmann, Helena Lejk
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 114, 2729-2734 (2017)
Early after entry into monocytes, macrophages, dendritic cells, and resting CD4 T cells, HIV encounters a block, limiting reverse transcription (RT) of the incoming viral RNA genome. In this context, dNTP triphosphohydrolase SAM domain and HD domain-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efb2b3ecca967b9c2d699c098055982
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53009
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53009
Autor:
Alexander Gerbaulet, Ursula Berka, Thomas Gramberg, Tina Schumann, Ulf Dittmer, Werner Mueller, Dirk Lindemann, Baek Kim, Laura A. Nguyen, Siegfried Weiss, Katrin Peschke, Sabine Wittmann, Kathrin Gibbert, Ronald Naumann, Stefan Lienenklaus, Nadja Schubert, Raymond Behrendt, Dimitra Alexopoulou, Axel Roers, Andreas Dahl
Publikováno v:
Cell reports
Cell Reports, Vol 4, Iss 4, Pp 689-696 (2013)
Cell Reports, Vol 4, Iss 4, Pp 689-696 (2013)
SUMMARY Aicardi-Goutières syndrome (AGS), a hereditary autoimmune disease, clinically and biochemically overlaps with systemic lupus erythematosus (SLE) and, like SLE, is characterized by spontaneous type I interferon (IFN) production. The finding t
Autor:
Tommy E. White, Caitlin Shepard, Baek Kim, Cindy Buffone, Borries Demeler, Dmitri N. Ivanov, Laura A. Nguyen, Akash Bhattacharya, Zhonghua Wang, Felipe Diaz-Griffero
Publikováno v:
Scientific Reports
SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but it remains controversial whe