Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Laura A. Maile"'
Publikováno v:
Journal of Diabetes Research, Vol 2014 (2014)
This study determined if blocking ligand occupancy of the αVβ3 integrin could inhibit the pathophysiologic changes that occur in the early stages of diabetic nephropathy (DN). Diabetic rats were treated with either vehicle or a monoclonal antibody
Externí odkaz:
https://doaj.org/article/0951f397a7bd4bd98163ee2a114df569
Autor:
Namrata G.R. Raut, Laura A. Maile, Leila M. Oswalt, Irati Mitxelena, Aaditya Adlakha, Kourtney L. Sprague, Ashley R. Rupert, Lane Bokros, Megan C. Hofmann, Jennifer Patritti-Cram, Tilat A. Rizvi, Luis F. Queme, Kwangmin Choi, Nancy Ratner, Michael P. Jankowski
SummaryPain of unknown etiology is frequent in individuals with the tumor predisposition syndrome Neurofibromatosis 1 (NF1), even when tumors are absent. Schwann cells (SC) were recently shown to play roles in nociceptive processing, and we find that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbff1a05aa1b73e322bcc5e956bd6d99
https://doi.org/10.1101/2023.03.18.533004
https://doi.org/10.1101/2023.03.18.533004
Autor:
Elizabeth P. Merricks, Walker H. Busby, Dwight A. Bellinger, Gang Xi, N. Gafbacik, K.P. Gollahan, W. L. Flowers, Timothy C. Nichols, Laura A. Maile, Kara R Stewart, David R. Clemmons, S. Gafbacik
Publikováno v:
Atherosclerosis. 258:40-50
Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (VSMC) to secrete ligands that bind to the αVβ3 integrin, a receptor that regulates VSMC proliferation and migration. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a510fbf36011db2baf4c0d96c70b8b3d
https://doi.org/10.1016/j.atherosclerosis.2017.01.030
https://doi.org/10.1016/j.atherosclerosis.2017.01.030
Autor:
Dwight A. Bellinger, W. L. Flowers, Matt D. Medlin, K. Gollahon, Walker H. Busby, Kara R Stewart, Paul Dunbar, Amit Patel, Stefani Garbacik, Timothy C. Nichols, David R. Clemmons, Laura A. Maile, Nikol Garbacik
Publikováno v:
Endocrinology. 155:4665-4675
Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells, including endothelial cells, resulting in activation of the αVβ3 integrin. This study determined whether blocking ligand occupancy of αVβ3 would inhibit the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c225b03e9d23b34f957c64b0e56129
https://doi.org/10.1210/en.2014-1318
https://doi.org/10.1210/en.2014-1318
Autor:
Melissa A. Solum, David R. Clemmons, Laura A. Maile, Gang Xi, Christine Wai, Clifford J. Rosen
Publikováno v:
Endocrinology. 154:4146-4157
IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8f99547f056ad0a00612b831c4bd9d
https://doi.org/10.1210/en.2013-1236
https://doi.org/10.1210/en.2013-1236
Autor:
David R. Clemmons, Masanobu Kawai, Teresa Cascella, Victoria E. DeMambro, Laura A. Maile, Christine Wai, Clifford J. Rosen
Publikováno v:
Journal of Bone and Mineral Research. 27:390-400
Global deletion of the Igfbp2 gene results in the suppression of bone turnover. To investigate the role of insulin-like growth factor-binding protein-2 (IGFBP-2) in regulating osteoclast differentiation, we cultured Igfbp2(-/-) bone marrow cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf8154c0b70a43f76b9acf7961a87b2
https://doi.org/10.1002/jbmr.545
https://doi.org/10.1002/jbmr.545
Publikováno v:
Diabetologia. 55:835-844
We have previously shown that the association of integrin-associated protein (IAP) with tyrosine phosphatase non-receptor type substrate-1 (SHPS-1) regulates the response of cells, including osteoclasts, osteoblasts, smooth muscle and retinal endothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7597e3ba793df3b9a54a30fc8d54d0d1
https://doi.org/10.1007/s00125-011-2416-x
https://doi.org/10.1007/s00125-011-2416-x
Publikováno v:
Diabetes
IGF-I–stimulated sarcoma viral oncogene (Src) activation during hyperglycemia is required for propagating downstream signaling. The aim of the current study was to determine the mechanism by which hyperglycemia enhances IGF-I–stimulated Src activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569692d48f220cbd1f0c80da19aa8003
https://doi.org/10.2337/db11-0990
https://doi.org/10.2337/db11-0990
Publikováno v:
Molecular Endocrinology. 25:1636-1649
IGF-I plays an important role in smooth muscle cell proliferation and migration. In vascular smooth muscle cells cultured in 25 mm glucose, IGF-I stimulated a significant increase in Src homology 2 domain containing protein tyrosine phosphatase subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de70b79c0803fb0c56409846a333b61
https://doi.org/10.1210/me.2011-0035
https://doi.org/10.1210/me.2011-0035
Publikováno v:
Endocrinology. 151:3611-3623
Hyperglycemia has been shown to induce the p66shc expression leading to increased reactive oxygen species (ROS) generation and apoptosis. In the present study, we demonstrated that hyperglycemia induced p66shc expression in vascular smooth muscle cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b025529527338f5765c985574b1cb944
https://doi.org/10.1210/en.2010-0242
https://doi.org/10.1210/en.2010-0242