Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Laura A. Laviolette"'
Autor:
Isabel A. Calvo, Shalini Sharma, Joao A. Paulo, Alexander O.D. Gulka, Andras Boeszoermenyi, Jingyu Zhang, Jose M. Lombana, Christina M. Palmieri, Laura A. Laviolette, Haribabu Arthanari, Othon Iliopoulos, Steven P. Gygi, Mo Motamedi
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103338- (2021)
Summary: The target of Rapamycin complex1 (TORC1) senses and integrates several environmental signals, including amino acid (AA) availability, to regulate cell growth. Folliculin (FLCN) is a tumor suppressor (TS) protein in renal cell carcinoma, whic
Externí odkaz:
https://doaj.org/article/4fe5db4627e54e2a8a995599fe937e78
Autor:
Laura A. Laviolette, Julien Mermoud, Isabel A. Calvo, Nicholas Olson, Myriam Boukhali, Ortrud K. Steinlein, Elisabeth Roider, Elke C. Sattler, Dachuan Huang, Bin Tean Teh, Mo Motamedi, Wilhelm Haas, Othon Iliopoulos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.
Externí odkaz:
https://doaj.org/article/1b380633bddc4eeeab34a8e2fe00f00a
Autor:
Andras Boeszoermenyi, Jose M. Lombana, Isabel A. Calvo, Othon Iliopoulos, Alexander O. D. Gulka, Laura A. Laviolette, Steven P. Gygi, Haribabu Arthanari, Shalini Sharma, Joao A. Paulo, Christina M. Palmieri, Mo Motamedi, Jingyu Zhang
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103338-(2021)
iScience, Vol 24, Iss 11, Pp 103338-(2021)
Summary The target of Rapamycin complex1 (TORC1) senses and integrates several environmental signals, including amino acid (AA) availability, to regulate cell growth. Folliculin (FLCN) is a tumor suppressor (TS) protein in renal cell carcinoma, which
Autor:
Laura A Laviolette, Jonas Wilson, Julia Koller, Christopher Neil, Peter Hulick, Tomas Rejtar, Barry Karger, Bin Tean Teh, Othon Iliopoulos
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66775 (2013)
The Birt-Hogg-Dube disease occurs as a result of germline mutations in the human Folliculin gene (FLCN), and is characterized by clinical features including fibrofolliculomas, lung cysts and multifocal renal neoplasia. Clinical and genetic evidence s
Externí odkaz:
https://doaj.org/article/9f02924d045942aa865210ebfded7ed8
Autor:
Wilhelm Haas, Julien Mermoud, Myriam Boukhali, Othon Iliopoulos, Dachuan Huang, Elisabeth Roider, Nicholas Olson, Mo Motamedi, Bin Tean Teh, Ortrud K. Steinlein, Laura A. Laviolette, Elke Sattler, Isabel A. Calvo
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
Germline mutations in the Folliculin (FLCN) tumour suppressor gene result in fibrofolliculomas, lung cysts and renal cancers, but the precise mechanisms of tumour suppression by FLCN remain elusive. Here we identify Rab7A, a small GTPase important fo
Autor:
Carol Perez‐Iratxeta, Neha Minhas, Barbara C. Vanderhyden, Laura A. Laviolette, Kendra M. Hodgkinson
Publikováno v:
International Journal of Cancer. Journal International du Cancer
Exogenous 17β-estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG-LS-TAg mouse model of the disease. We hypothesized that E2 has direct effects on ovarian cancer cells and this study was designed to determine the mol
Autor:
Patricia Schildknecht, Jenny Lee, Cynthia J. Guidi, Stefanie Fischer, Christian Reichen, Katherine Francisco, Wei Li, Christopher Espelin, Megan E. Fuller, Tanja Hospodarsch, Dan Snell, Sharlene Adams, Stuart W. Hicks, Kerry Donahue, Laura A. Laviolette, Anna Skaletskaya, Qifeng Qiu, Rebecca McCarthy, Emily E. Reid, Luke Harris, Carla Marashio, Kerstin Sinkevicius, Zita Arany, Stephen M. Abbott
Publikováno v:
Cancer Research. 79:215-215
DARPin® molecules are small engineered proteins, derived from natural ankyrin repeat proteins that are selected to bind to specific targets with high affinity. Individual DARPin® molecules can be linked together genetically in order to create multi
Autor:
Joanne K. Kelleher, Paulo A. Gameiro, Laura A. Laviolette, Gregory Stephanopoulos, Othon Iliopoulos
Publikováno v:
Journal of Biological Chemistry. 288:12967-12977
Cancer and proliferating cells exhibit an increased demand for glutamine-derived carbons to support anabolic processes. In addition, reductive carboxylation of α-ketoglutarate by isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) was recently shown to b
Autor:
Othon Iliopoulos, Christopher Neil, Tomas Rejtar, Laura A. Laviolette, Peter J. Hulick, J.F. Wilson, Barry L. Karger, Bin Tean Teh, Julia Koller
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e66775 (2013)
PLoS ONE, Vol 8, Iss 7, p e66775 (2013)
The Birt-Hogg-Dube disease occurs as a result of germline mutations in the human Folliculin gene (FLCN), and is characterized by clinical features including fibrofolliculomas, lung cysts and multifocal renal neoplasia. Clinical and genetic evidence s
Autor:
Jean-François Ethier, Laura A. Laviolette, Mary K. Senterman, Barbara C. Vanderhyden, Patrick J Devine
Publikováno v:
Menopause (New York, N.Y.). 18(5)
Objective Ovarian cancer is often diagnosed in women after menopause when the levels of the serum gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are increased because of the depletion of growing follicles within the ova