Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Laura A. Kirkman"'
Autor:
Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco-Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A. Kirkman, Huilin Li, Gang Lin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous drug target because its inhibition kills P. falciparum in multiple stages of its life cycle and synergizes with artemisinins. We recently developed a mac
Externí odkaz:
https://doaj.org/article/c572579ac9434308b55f8122c4687613
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102896- (2024)
Summary: Artezomibs (ATZs), dual-pharmacophore molecules comprising of artemisinin and a parasite proteasome inhibitor, hijack parasite ubiquitin proteasome system to transform into new proteasome inhibitors following the activation of artemisinin by
Externí odkaz:
https://doaj.org/article/52f37ef739484e0dabb9c8bfe9bce4c6
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102082- (2021)
Summary: Malaria remains a major cause of morbidity and mortality in the developing world. Recent work has implicated chromosome end stability and the repair of DNA breaks through telomere healing as potent drivers of variant antigen diversification,
Externí odkaz:
https://doaj.org/article/a49600d3f1b8436aa5c19c8808ac5e33
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT The protozoan parasites that cause malaria infect a wide variety of vertebrate hosts, including birds, reptiles, and mammals, and the evolutionary pressures inherent to the host-parasite relationship have profoundly shaped the genomes of bot
Externí odkaz:
https://doaj.org/article/1b641e93a574455385147c953cc5bf20
Autor:
Susannah F. Calhoun, Jake Reed, Noah Alexander, Christopher E. Mason, Kirk W. Deitsch, Laura A. Kirkman
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The human malaria parasite Plasmodium falciparum replicates within circulating red blood cells, where it is subjected to conditions that frequently cause DNA damage. The repair of DNA double-stranded breaks (DSBs) is thought to rely almost e
Externí odkaz:
https://doaj.org/article/ed4d29f4bee646ababc123c1ab14efe7
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 66:1484-1508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::396cefbba4bbff5c41d426f4caafe461
https://doi.org/10.1021/acs.jmedchem.2c01651
https://doi.org/10.1021/acs.jmedchem.2c01651
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:9350-9375
With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b58c6b8b4be75e0e7350e808c708fd6
https://doi.org/10.1021/acs.jmedchem.2c00611
https://doi.org/10.1021/acs.jmedchem.2c00611
Autor:
Shreeya Garg, Oriana Kreutzfeld, Sevil Chelebieva, Patrick K. Tumwebaze, Oswald Byaruhanga, Martin Okitwi, Stephen Orena, Thomas Katairo, Samuel L. Nsobya, Melissa D. Conrad, Ozkan Aydemir, Jennifer Legac, Alexandra E. Gould, Brett R. Bayles, Jeffrey A. Bailey, Maelle Duffey, Gang Lin, Laura A. Kirkman, Roland A. Cooper, Philip J. Rosenthal
Publikováno v:
Antimicrobial agents and chemotherapy, vol 66, iss 10
Antimicrob Agents Chemother
Antimicrob Agents Chemother
The proteasome is a promising target for antimalarial chemotherapy. We assessed ex vivo susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bc34406b4545749259203028861266
https://escholarship.org/uc/item/8dm1n152
https://escholarship.org/uc/item/8dm1n152
Autor:
Wenhu Zhan, Daqiang Li, Shubha Bevkal Subramanyaswamy, Yi Jing Liu, Changmei Yang, Hao Zhang, Jacob C. Harris, Rong Wang, Songbiao Zhu, Hedy Rocha, Julian Sherman, Junling Qin, Mikayla Herring, Nelson V. Simwela, Andrew P. Waters, George Sukenick, Liwang Cui, Ana Rodriguez, Haiteng Deng, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Cell Chemical Biology. 30:457-469.e11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6091c96a7bce2b703febc35cbe175f0d
https://doi.org/10.1016/j.chembiol.2023.04.006
https://doi.org/10.1016/j.chembiol.2023.04.006
Publikováno v:
Mol Microbiol
Malaria caused by the protozoan parasite Plasmodium falciparum continues to impose significant morbidity and mortality, despite substantial investment into drug and vaccine development and deployment. Underlying the resilience of this parasite is its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd7936e229498d0ad03b332be8cdcd2
https://doi.org/10.1111/mmi.14632
https://doi.org/10.1111/mmi.14632