Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Laura A. Jaenicke"'
Autor:
Stefanie Peter, Jennyfer Bultinck, Kevin Myant, Laura A Jaenicke, Susanne Walz, Judith Müller, Michael Gmachl, Matthias Treu, Guido Boehmelt, Carsten P Ade, Werner Schmitz, Armin Wiegering, Christoph Otto, Nikita Popov, Owen Sansom, Norbert Kraut, Martin Eilers
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1525-1541 (2014)
Abstract Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF‐BP1, MULE) associates with both MYC and the MYC‐associated protein MI
Externí odkaz:
https://doaj.org/article/285765620d5f424582909a71e1e55870
Autor:
Martin Eilers, Laura A. Jaenicke, Wenshan Xu, Anne Carstensen, Elmar Wolf, Björn von Eyss, Matthias Geyer, Ann Katrin Greifenberg, Nikita Popov
Publikováno v:
Molecular Cell. 61(1):54-67
MYC is an unstable protein, and its turnover is controlled by the ubiquitin system. Ubiquitination enhances MYC-dependent transactivation, but the underlying mechanism remains unresolved. Here we show that MYC proteasomal turnover is dispensable for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b00eab536283b63b9b51aa0762a348
Autor:
Leigh-Anne McDuffus, Markus Sauer, Björn von Eyss, Laura A. Jaenicke, Martin Eilers, Sebastian Letschert, Roderik M. Kortlever, Nadine Royla, Stefan Kempa, Andreas Rosenwald, Katrin E. Wiese, Gerard I. Evan
Publikováno v:
Cancer Cell. 28:743-757
In several developmental lineages, an increase in MYC expression drives the transition from quiescent stem cells to transit-amplifying cells. We show that MYC activates a stereotypic transcriptional program of genes involved in cell growth in mammary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0aee38162425343ad4a8414c90cd96
https://doi.org/10.1016/j.ccell.2015.10.013
https://doi.org/10.1016/j.ccell.2015.10.013
Autor:
Nikita Popov, Matthias Treu, Norbert Kraut, Owen J. Sansom, Martin Eilers, Carsten P. Ade, Christoph Otto, Guido Boehmelt, Stefanie Peter, Michael Gmachl, Kevin Myant, Susanne Walz, Judith Müller, Armin Wiegering, Werner Schmitz, Jennyfer Bultinck, Laura A. Jaenicke
Publikováno v:
EMBO Molecular Medicine
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF-BP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615bee3150896b58f3bab2f281c2967c
http://europepmc.org/articles/PMC4287973
http://europepmc.org/articles/PMC4287973
Autor:
Nikita Popov, Axel Behrens, Bradley Spencer-Dene, Markus E. Diefenbacher, Sophia M. Blake, Christina Schülein-Völk, Martin Eilers, Laura A. Jaenicke, Emma Nye
Publikováno v:
Journal of Clinical Investigation. 124:3407-3418
Colorectal cancer is the third most common cancer worldwide. Although the transcription factor c-MYC is misregulated in the majority of colorectal tumors, it is difficult to target directly. The deubiquitinase USP28 stabilizes oncogenic factors, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740faca336aec7790f68e2c70cc44390
https://doi.org/10.1172/jci73733
https://doi.org/10.1172/jci73733
Publikováno v:
Molecular Biology of the Cell
The lectin Yos9p is a subunit of the HRD ligase that partakes in the degradation of aberrant glycoproteins from the ER. We demonstrate that a variant of Yos9p that has lost its ability to bind glycans enhances the elimination of non-glycosylated subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6632b4c6034a51192ab4d1f10d556e3
http://europepmc.org/articles/PMC3154888
http://europepmc.org/articles/PMC3154888
Publikováno v:
Nature cell biology. 12(10)
The SCFFbw7 ubiquitin ligase mediates growth-factor-regulated turnover of the Myc oncoprotein. Here we show that SCFβ-TrCP binds to Myc by means of a characteristic phosphodegron and ubiquitylates Myc; this results in enhanced Myc stability. SCFFbw7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0dcb8f8a5f34adc62a63840e4655f7
https://pubmed.ncbi.nlm.nih.gov/20852628
https://pubmed.ncbi.nlm.nih.gov/20852628
Publikováno v:
Molecular Cancer Research. 13:B19-B19
For the maintenance of a given tissue it is absolutely critical to balance proliferation and differentiation of stem cells, progenitor cells and terminally differentiated cells. Perturbations of these finely tuned processes can lead to various diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4536f0d713c198a5c39fbc2b8f031850
https://doi.org/10.1158/1557-3125.myc15-b19
https://doi.org/10.1158/1557-3125.myc15-b19