Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Laura A. Coughlin"'
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 3, Pp 150-158 (2024)
Introduction: Disparities in incidence and outcome of rectal cancer are multifactorial in etiology but may be due, in part, to differences in gut microbiome composition. We used serial robust statistical approaches to assess baseline gut microbiome c
Externí odkaz:
https://doaj.org/article/acbcefdb049a449e8bad6ad51dac3d27
Autor:
Arthur E. Frankel, Laura A. Coughlin, Jiwoong Kim, Thomas W. Froehlich, Yang Xie, Eugene P. Frenkel, Andrew Y. Koh
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 848-855 (2017)
This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer
Externí odkaz:
https://doaj.org/article/ea0024564b1a4bd1a29081adc26b618c
Autor:
Laura L. Coughlin, Janna M. Schurer, Carene Umubyeyi, Salome Sijenyi, Khurram Arif, Vivianne Umuhire Niyonkuru, Emmanuel Byiringiro, Naomi Lutz, Noel Korukire, Susan Murcott, Hellen J. Amuguni
Publikováno v:
Journal of Water, Sanitation and Hygiene for Development, Vol 12, Iss 3, Pp 286-301 (2022)
In 2018, rural residents of northern Rwanda raised water, sanitation, and hygiene (WASH) access and availability as a community concern; however, no baseline information was available to prioritize communities for intervention. This study aimed to as
Externí odkaz:
https://doaj.org/article/24b496b0f06d449f8b873bfddcc6ad81
Autor:
Yongbin Choi, Jake N. Lichterman, Laura A. Coughlin, Nicole Poulides, Wenling Li, Priscilla Del Valle, Suzette N. Palmer, Shuheng Gan, Jiwoong Kim, Xiaowei Zhan, Yajing Gao, Bret M. Evers, Lora V. Hooper, Chandrashekhar Pasare, Andrew Y. Koh
Publikováno v:
Science Immunology. 8
Gut microbiota, specifically gut bacteria, are critical for effective immune checkpoint blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment extraintestinal anticancer immune responses, however, are largely unknown. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24fde688be2f488c3e7a8faff36b6326
https://doi.org/10.1126/sciimmunol.abo2003
https://doi.org/10.1126/sciimmunol.abo2003
Autor:
Laura L. Coughlin, Carlos R. Sanchez, Margot I. Monti, John A. Griffioen, Felicia B. Nutter, Gillian L. Beamer
Publikováno v:
American Journal of Veterinary Research. 83
OBJECTIVE To determine (1) if chemokine (C-X-C motif) ligand 1 (CXCL1), matrix metalloproteinase 8 (MMP8), interleukin-10 (IL-10), interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) can be detected in serum from Asian elephants, and (2) if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f8997c3e00e174cefca4c186cb460c
https://doi.org/10.2460/ajvr.22.01.0016
https://doi.org/10.2460/ajvr.22.01.0016
Autor:
Qiwei Li, Laura A. Coughlin, Abu Minhajuddin, Andrew H. Czysz, Sarah K. Hussain, Andrew Y. Koh, Brittany L. Mason, Madhukar H. Trivedi
Publikováno v:
Journal of Affective Disorders. 266:394-401
Characterise gut microbiota distributions of participants with co-occurring depression and anxiety, in those with only depression or with anxiety, and determine if gut bacteria differentially correlates with distinct clinical presentations.Participan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8bdcd15f2e3c0d212119422261fedb
https://doi.org/10.1016/j.jad.2020.01.137
https://doi.org/10.1016/j.jad.2020.01.137
Autor:
Yongbin Choi, Yajing Gao, Laura A. Coughlin, Nicole Poulides, Jiwoong Kim, Xiaowei Zhan, Lora V. Hooper, Chandrashekhar Pasare, Andrew Y. Koh
Gut microbiota are critical for effective immune checkpoint blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment extraintestinal anti-cancer immune responses, however, are largely unknown. Here, we find that ICT induces t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326136703d034b23a6f68c02d9985132
https://doi.org/10.1101/2022.01.26.477865
https://doi.org/10.1101/2022.01.26.477865
Autor:
Krystin Deason, Igor Dozmorov, Isabella Rauch, Bret M. Evers, Edward K. Wakeland, Chandrashekhar Pasare, Yajing Gao, Aakanksha Jain, Andrew Y. Koh, Laura A. Coughlin, Ricardo A. Irizarry-Caro
Publikováno v:
The Journal of Experimental Medicine
Gao et al. reveal that DCs shape a distinct pathogen-specific CD4 T cell transcriptome and discover an unexpected role for T cell–intrinsic caspase-1 in promoting Th17 differentiation.
Dendritic cells (DCs) are critical for the differentiation
Dendritic cells (DCs) are critical for the differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2c6b072181f41f829ababcce3b0d86
https://doi.org/10.1084/jem.20190476
https://doi.org/10.1084/jem.20190476
Publikováno v:
Journal of pediatric surgery. 55(5)
Babies with short bowel syndrome (SBS) have small intestinal microbial disturbances that impact gut function. Characterizing the small bowel microbiota is challenging, and the utility of sampling stool is unclear. This study compares the microbiota f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c188ea0fc386f18ea316b44f3e2929
https://pubmed.ncbi.nlm.nih.gov/32063370
https://pubmed.ncbi.nlm.nih.gov/32063370
Autor:
Yang Xie, Laura A. Coughlin, Arthur E. Frankel, Andrew Y. Koh, Eugene P. Frenkel, Jiwoong Kim, Thomas W. Froehlich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 848-855 (2017)
This is the first prospective study of the effects of human gut microbiota and metabolites on immune checkpoint inhibitor (ICT) response in metastatic melanoma patients. Whereas many melanoma patients exhibit profound response to ICT, there are fewer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a71ec9138719aa0ca8e4e4cb24af1c6
http://www.sciencedirect.com/science/article/pii/S1476558617302385
http://www.sciencedirect.com/science/article/pii/S1476558617302385